Plasticizer effect and comparative evaluation of cellulose acetate and ethylcellulose-HPMC combination coatings as semipermeable membranes for oral osmotic pumps of naproxen sodium

The objective of this study was to compare the performance of cellulose acetate (CA) and ethylcellulose (EC)-HPMC combination coatings as semipermeable membranes (SPMs) for osmotic pump tablets (OPTs) of naproxen sodium (NPS) so as to deliver a constant, predetermined amount of drug in solution form over a fixed span of time, independent of external environmental conditions. Osmotic pump tablets were designed with different coating variables and optimized in terms of nature of plasticizer, membrane thickness, and orifice diameter. The effect of insertion of an inner microporous film around the NPS core to minimize deformation of the SPM due to peristaltic movement of the gut was also studied. Osmotic pump tablets composed of membranes with water-soluble plasticizer, propyleneglycol (PG), released drug mainly through diffusion, whereas those designed with CA and EC-HPMC (4:1) coats containing water-insoluble plasticizer, castor oil, released their contents by perfect zero-order kinetics over a prolonged period of time, though the average release rate that could be achieved with the EC-HPMC (4:1) membrane was only about half the rate achieved with the CA membrane for the same membrane thickness. Release rates for both the membranes decreased with increasing membrane thickness and were found to be independent of orifice diameter, agitation intensity, and pH of the dissolution medium.     

Digit pipelined arithmetic on fine-grain array processors

In this paper, we present a novel scheme for performing fixed-point arithmetic efficiently on fine-grain, massively parallel, programmable architectures including both custom and FPGA-based systems. We achieve anO(n) speedup, wheren is the operand precision, over the bit-serial methods of existing fine-grain systems such as the DAP, the MPP and the CM2, within the constraints of regular, near neighbor communication and only a small amount of on-chip memory. This is possible by means of digit pipelined algorithms which avoid broadcast and which operate in a fully systolic manner by pipelining at the digit level. A base 4, signed-digit, fully redundant number system and on-line techniques are used to limit carry propagation and minimize communication costs. p ]Although our algorithms are digit-serial, we are able to match the performance of the bit-parallel methods, while retaining low communication complexity. Reconfigurable hardware systems built using field programmable gate arrays (FPGA's) can share in the speed benefits of these algorithms. By using the organization of logic blocks suggested in this paper, problems of placement and routing that exist in such systems can be avoided. Since the algorithms are amenable to pipelining, very high throughput can be obtained.     

Optimum difference mode excitations for monopulse arrays

A technique has been developed to obtain optimum difference mode excitations for monopulse arrays. In addition, a direct interpolation scheme has been devised for situations where near-optimum results would suffice. A parameter designated asu_{0}is identified with every optimum difference pattern. The choice of this parameteru_{0}determines the sidelobe level of the optimum pattern. The problem of obtaining the optimum excitations has been shown to be reducible to one of finding out the best approximation that minimizes the maximum deviation (minimax) from the real line (u = betad cos varpaxis), over a range determined byu_{0}. This latter problem has been solved using a modified Remez exchange algorithm. An extensive set of design curves has also been presented.     

A quick method for estimation of long-lived alpha activity in work atmospheres

In an operating plant quick reporting of the status of long-lived alpha activity concentrations in the work atmosphere is required. This will help in taking any corrective control measures if required. Radon and thoron progeny concentrations prevalent in the general atmosphere predominantly interfere in measurement of long-lived alpha activity in air. The alpha counts due to radon and thoron progeny vary widely in many atmospheric conditions. Therefore, conventionally, 5 days delay is allowed for all interfering activity to decay completely and true alpha air activity is then estimated. An approach for quick assessment of long-lived alpha activity by eliminating interference due to radon and thoron progeny in air, is made here. Based on the study of the pattern of alpha count rate due to radon and thoron progeny in air, a method for estimation of long-lived alpha activity within 8 hours delay time is suggested in this paper.     

Numerical Investigation of the Effect of Vertical Load on the Lateral Response of Piles

The laboratory and field test data on the response of piles under the combined action of vertical and lateral loads is rather limited. The current practice for design of piles is to consider the vertical and lateral loads independent of each other. This paper presents some results from three-dimensional finite-element analyses that show the significant influence of vertical loads on a pile’s lateral response. The analyses were performed in both homogeneous clayey soils and homogeneous sandy soils. The results have shown that the influence of vertical loads on the lateral response of piles is to significantly increase the capacity in sandy soils and marginally decrease the capacity in clayey soils. In general, it was found that the effect of vertical loads in sandy soils is significant even for long piles, which are as long as 30 times the pile width, while in the case of clayey soils, the effect is not significant for piles beyond a length of 15 times the width of the pile. The design bending moments in the laterally loaded piles were also found to be dependent on the level of vertical load on the piles.     

Photocatalytic degradation of dye pollutants under solar,visible and UV lights using green synthesised CuS nanoparticles

A green method for the solvothermal synthesis of copper sulphide nanoparticles (CuS NPs) using xanthan gum as a capping agent was developed. The CuS NPs were characterised by scanning electron microscopy, transmission electron microscopy (TEM), X-ray diffraction, Brunauer–Emment–Teller, zeta analysis, thermal gravimetric– differential thermal analysis, Fourier transform infrared and UV–visible absorption spectra. These characterisations together determine the composition, structural, thermal and optical properties. The UV–visible spectrum had a broad absorption in the visible range. The particle size of the products was observed by TEM in the range of 8–20 nm. The photocatalytic performance of the CuS NPs was evaluated for the degradation of organic dyes (methylene blue, rhodamine B, eosin Y and congo red) under irradiation of solar, visible and UV lights. The CuS NPs showed good photocatalytic activity. Kinetic analyses indicate that the photodegradation rates of dyes usually follow pseudo-first-order kinetics for degradation mechanisms.     

Stability and Mobility of Sand-Bed Channels Affected by Seepage

Seepage effects on the stability, mobility, and incipient motion of sand-bed particles are experimentally investigated. Seepage through a sand bed in a downward direction (suction) reduces the stability of particles, and it can even initiate their movement. The bed erosion is increased with the increased rates of suction. Whereas the seepage in an upward direction (injection) increases the stability of bed particles, it does not aid initiating their movement. The rate of bed erosion is reduced or even stopped by the increased injection rates. Hydrodynamic conditions leading to the so-called “pseudoincipient motion” with suction (for the initiation of particles movement that are otherwise at rest under no-seepage conditions), and with injection (for only arresting the particles movement that are otherwise moving initially) are evaluated. The conventional Shields curve cannot be used to predict such pseudoincipient motion conditions with seepage. The concepts thus developed are useful for a better understanding of the sediment transport mechanics and in the design of stable alluvial channels affected by seepage.     

Asia energy mixes from socio-economic and environmental perspectives

Sustainable clean energy is the top social, economic, and environmental agenda of political leaders, policy makers, enlightened business executives, and civil society in Asia. Strong economic growth in Asia has caused a great demand for energy which has resulted in an enormous increase in CO₂ emissions. The association of Southeast Asian nations (ASEAN), India, China, South Korea and Japan are the most important regions in Asia as their economies have been growing steadily. These countries though heavily dependent on fossil fuels have stepped up their measures towards low-carbon society amid domestic affordability challenges and changing global mindset. This report highlights the current energy scenario in these countries and their effort towards an affordable and sustainable clean energy future. The energy policy to enhance energy security and improve environmental sustainability is also explicated in this article.     

Zinc Titanate Nanofibers for the Detoxification of Chemical Warfare Simulants

Fabrication of a novel ceramic nanofiber system viz. zinc titanate using the well-known electrospinning technology with polyvinylpyrrolidone as a binder is reported. Use of zinc titanates as reactive sorbents to detoxify chemical warfare agents is hypothesized and proved. The zinc titanate nanofibers are tested against simulants of nerve and mustard agents and show satisfactory destructive activity. The extent of detoxification is measured using GC-MS analysis. The products of reaction of zinc titanate against the simulants are identified and are found to be relatively harmless. The possibility of replacement of conventional-activated carbon by electrospun ceramic nanofibers for face masks and protective clothing is proposed.     

Generating vegetation leaf area index earth system data record from multiple sensors. Part 1: Theory

The generation of multi-decade long Earth System Data Records (ESDRs) of Leaf Area Index (LAI) and Fraction of Photosynthetically Active Radiation absorbed by vegetation (FPAR) from remote sensing measurements of multiple sensors is key to monitoring long-term changes in vegetation due to natural and anthropogenic influences. Challenges in developing such ESDRs include problems in remote sensing science (modeling of variability in global vegetation, scaling, atmospheric correction) and sensor hardware (differences in spatial resolution, spectral bands, calibration, and information content). In this paper, we develop a physically based approach for deriving LAI and FPAR products from the Advanced Very High Resolution Radiometer (AVHRR) data that are of comparable quality to the Moderate resolution Imaging Spectroradiometer (MODIS) LAI and FPAR products, thus realizing the objective of producing a long (multi-decadal) time series of these products. The approach is based on the radiative transfer theory of canopy spectral invariants which facilitates parameterization of the canopy spectral bidirectional reflectance factor (BRF). The methodology permits decoupling of the structural and radiometric components and obeys the energy conservation law. The approach is applicable to any optical sensor, however, it requires selection of sensor-specific values of configurable parameters, namely, the single scattering albedo and data uncertainty. According to the theory of spectral invariants, the single scattering albedo is a function of the spatial scale, and thus, accounts for the variation in BRF with sensor spatial resolution. Likewise, the single scattering albedo accounts for the variation in spectral BRF with sensor bandwidths. The second adjustable parameter is data uncertainty, which accounts for varying information content of the remote sensing measurements, i.e., Normalized Difference Vegetation Index (NDVI, low information content), vs. spectral BRF (higher information content). Implementation of this approach indicates good consistency in LAI values retrieved from NDVI (AVHRR-mode) and spectral BRF (MODIS-mode). Specific details of the implementation and evaluation of the derived products are detailed in the second part of this two-paper series.