Liposomes as Carriers of Antimicrobial Drugs

Liposome are promising drug carrier systems being developed. Their successful use in the treatment of several diseases demonstrates that a solid rationale for clinical development of liposomes as antimicrobial drug carriers can be established. There are a number of potential drug candidates for liposome encapsulation. The involvement of several biotechnology companies has culminated in the design and licensing of formulations for the treatment of certain microbial infections and cancers. Understanding of liposome behavior in the body and of the physicochemical mechanisms involved in the interaction of liposome, drug, and cellular targets is essential for their future applications.     

Rheological properties of hydroxyl‐terminated and end‐capped aliphatic hyperbranched polyesters

The rheological behavior of two series of aliphatic hyperbranched (HB) polyesters, based on 2,2‐bis(hydroxymethyl)propionic acid (bis‐MPA) and di‐trimethylol propane (Di‐TMP) as a tetrafunctional core, was studied. The effect of the size (pseudo‐generation number, from second to eight) and structure on the melt rheological properties was investigated for a series of hydroxyl‐terminated HB polyesters. In addition, the influence of the nature and degree of modification of the terminal OH groups in a series of fourth‐generation polyesters end‐capped with short and long alkyl chains and some aryl groups on the rheological properties was analyzed. The time–temperature superposition procedure was applied for the construction of master curves and for the analysis of the rheological properties of HB polyesters. The data obtained from WLF analysis of the HB polyesters showed that the values of the thermal coefficient of expansion of free volume α_f and the fractional free volume at the glass transition temperature, f_g, increase with increasing size of the HB polyesters. It was shown that the modified HB polyesters exhibited lower T_g and T_G′=G″ temperatures, above which viscous became dominant over elastic behavior. From an analysis of the master curves of the modified HB polyesters, it was observed that with increasing degree of modification, both storage and loss modules and complex dynamic viscosity and apparent energy for viscoelastic relaxation decrease, because of reduced intermolecular hydrogen interactions. They do not exhibit a plateau of rubbery behavior, which confirms that no entanglements are present and that the molar masses are below the critical molar mass. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41479.     

含α—磺基脂肪酸甲酯的高性能液体餐具洗涤剂（英）

详细地介绍了α－磺基脂肪酸甲酯（ＳＭＥ）优良的发泡力、去污力及水溶性。ＳＭＥ的诸多特性使它成为普通及超浓缩餐具洗涤剂的理想原料。介绍了ＳＥＭ的制备工艺以及基于ＳＭＥ的配方特性。     

Equilibrium mode distribution and steady-state distribution in 100-400 μm core step-index silica optical fibers

Using the power flow equation, the state of mode coupling in 100-400 μm core step-index silica optical fibers is investigated in this article. Results show the coupling length L(c) at which the equilibrium mode distribution is achieved and the length z(s) of the fiber required for achieving the steady-state mode distribution. Functional dependences of these lengths on the core radius and wavelength are also given. Results agree well with those obtained using a long-established calculation method. Since large core silica optical fibers are used at short distances (usually at lengths of up to 10 m), the light they transmit is at the stage of coupling that is far from the equilibrium and steady-state mode distributions.     

Multicomponent mass transfer across water films during hydrocarbon gas injection

Understanding the dynamics of pore-scale multicomponent gas and oil mass transfer across water films during hydrocarbon gas injection in petroleum reservoirs is important in the design of tertiary oil recovery schemes at the field scale. The water films prevent oil and gas coming into direct contact and, for miscible gas injection, delay the onset of miscibility. We use a pore-scale model to describe the diffusion-controlled mass transfer through the water films. The following different processes are found: (i) rapid oil swelling which results in short times needed to rupture the water films shielding the oil, (ii) slow oil swelling resulting in very long water film rupture times and (iii) both oil swelling and oil shrinking. The rate of oil recovery and the way it is recovered (either by rupturing the water film or being vaporized into the displacing gas) is critically dependent upon the oil and gas compositions, the oil droplet size and the water film thickness. We show cases at the pore scale where the time for gas and oil to be brought into direct contact and reach equilibrium in the presence of water films during miscible gas displacement is so long that water-blocking will adversely affect oil recovery at the field scale.     

DNA damage by PAH and repair in a marine sponge

The sponge Tethya lyncurium from the Northern Adriatic has been used as an experimental species.A method is outlined for preparation of DNA which yields a highly purified DNA with a double-strand (ds) molecular weight of 25 M-dalton between single-strand (ss) breaks, which when properly damaged can be cut opposite to ss-breaks with nuclease s₁. The molecular weights of the resulting ds-DNA pieces and their distribution has been evaluated by electron microscope photographs.Sponges exposed to benzo[a]pyrene (BaP) in the dark only incorporate BaP-derivatives (BaPD) in small amounts, if any. However, in the presence of light, derivatization to BaP derivatives enables effective coupling to occur, as shown previously (R. K. Zahn et al., 1981). Sponges were exposed to radiolabeled BaP in the presence of light. Coupling of BaPD to the DNA as well as the induction of ss-breaks were measured.Light-mediated coupling is concentration dependent from 0.01 – 20 ppb BaP with a correlation coefficient of r = 0.84.Under conditions of possible repair, ss-breaks completely disappear from sponge DNA in the course of three weeks while a substantial fraction of the BaP derivatives persists.Double label experiments show that substantial DNA synthesis occurs during this time. Pollution causes a decrease of the molecular weight of unnicked DNA, re-incubation in clean water an increase. A DNA species of 24 M-dalton seems to play a critical role. If its percentage in the DNA population drops below a critical level, recovery is not longer possible. DNA damage by PAH and repair in sponges seems to differ from that of most eucaryotes.     

Cylindrical antennas with constant capacitive loading

Experimental and theoretical values of admittance are presented for a monopole antenna made in the form of a row of identical conducting, mutually insulated cylinders. The influence of the number of cylinders making monopoles of equal length and with equal total gapwidths between the cylinders is analysed. It was found that such antennas exhibit broadband properties similar to those of antennas with tapered capacitive loading.     

Microbiological water quality along the Danube River: Integrating data from two whole-river surveys and a transnational monitoring network

The River Danube is with 2780 km the second longest river in Europe. Its catchment area covers 801 500 km², with approximately 81 million inhabitants in 19 countries. River water for anthropogenic use, transportation and recreation is of major importance in all of these countries. Microbiological contamination from faecal pollution by anthropogenic sources is considered to be a crucial problem throughout the Danube River basin. Thus, detailed knowledge on the extent and the origin of microbial pollution is essential for watershed management. The determination of faecal indicator concentrations along the Danube and its major tributaries during two whole-river surveys and 16 permanent stations allowed for the first time to draw a clear picture of the faecal pollution patterns along the whole longitudinal profile of this important international river. By including a variety of environmental variables in statistical analysis, an integrative picture of faecal pollution in the Danube River basin could be evolved. Four hot spots and six stretches of differing faecal pollution were identified, mainly linked with input from large municipalities. Significant decline of microbiological pollution was observed in the upper and lower Danube stretches over the investigation period. In contrast, a significant increase in the middle part was evident. The planned implementation of new wastewater treatment plants and advanced wastewater treatment measures according to the European Union urban wastewater directive will have a great potential to reduce microbial faecal pollution in the Danube and thus improving water quality.