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61.
Thirty-five male patients, aged 34-79 yr, with definite rheumatoid arthritis (RA) were recruited from out-patient clinics and randomized to receive monthly injections of testosterone enanthate 250 mg or placebo as an adjunct therapy for 9 months. Endpoints included disease activity parameters and bone mineral density (BMD). At baseline, there were negative correlations between the ESR and serum testosterone (r = -0.42, P < 0.01) and BMD (hip, r = -0.65, P < 0.01). A total of 29.6% of all patients had at least one vertebral fracture, most having multiple fractures. Back pain, however, was not more prevalent in fracture patients (55% vs 50%). Disease activity was significantly higher in the fracture group (joint score P < 0.05, rheumatoid factor P < 0.01). Thirty patients completed the trial, 15 receiving testosterone and 15 receiving placebo. There were significant rises in serum testosterone, dihydrotestosterone and oestradiol in the treatment group. There was no significant effect of treatment on disease activity overall, five patients receiving testosterone underwent a "flare'. Differences in mean BMD following testosterone or placebo were non-significant (spine: +1.2% vs -1.1%; femur: -0.3% vs +0.3%). There was no suggestion of a positive effect of testosterone on disease activity in men with RA.  相似文献   
62.
In this paper, an adaptive controller with structurally dynamic wavelet network is developed for a harmonic drive subject to parameter varying friction. The control architecture integrates a proportional controller, a feedback adaptive component and sliding component to adaptively compensate for the friction to achieve accurate position tracking. Global asymptotic stability of the algorithm is proved by using Lyapunov function. In parallel to the adaptive controller, a fuzzy reconfiguration scheme is devised to change the structure of the network along with weights updating to improve the system tracking performance and robustness. Experimental tests on a harmonic drive manipulator verify the effectiveness of the proposed control method.  相似文献   
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64.
Continuing, severe outbreaks of mountain pine beetle (Dendroctonus ponderosae) across western North America have resulted in widespread mortality of lodgepole pine (Pinus contorta). Multiple studies have used high spatial resolution satellite data to map areas of beetle kill; these studies have largely focused on mapping red canopy cover associated with recent tree mortality and have not examined mapping gray canopy cover that occurs after red needles have dropped. The work presented here examines the use of newly available GeoEye-1 data for mapping both red and gray canopy area in southeastern Wyoming lodgepole pine forest. A 0.5 m spatial resolution, pan-sharpened GeoEye-1 image was used to classify areas of green, red, and gray canopy cover. Reference data were collected at twelve 500 m2 field plots. Shadow-normalized green, red, and gray canopy area from classified GeoEye-1 data closely agreed with field-estimated green, red, and gray canopy area. Mean absolute error in canopy cover for the twelve sample plots was 8.3% for the green class, 5.4% for the red class, and 7.2% for the gray class. When all twelve plots were aggregated, remotely sensed estimates of green, red, and gray cover were within 1.7% of the field-estimated cover. Our results demonstrate that high spatial resolution spaceborne multispectral data are a promising tool for mapping canopy mortality caused by mountain pine beetle outbreaks.  相似文献   
65.
The node-link diagram is an intuitive and venerable way to depict a graph. To reduce clutter and improve the readability of node-link views, Holten & van Wijk's force-directed edge bundling employs a physical simulation to spatially group graph edges. While both useful and aesthetic, this technique has shortcomings: it bundles spatially proximal edges regardless of direction, weight, or graph connectivity. As a result, high-level directional edge patterns are obscured. We present divided edge bundling to tackle these shortcomings. By modifying the forces in the physical simulation, directional lanes appear as an emergent property of edge direction. By considering graph topology, we only bundle edges related by graph structure. Finally, we aggregate edge weights in bundles to enable more accurate visualization of total bundle weights. We compare visualizations created using our technique to standard force-directed edge bundling, matrix diagrams, and clustered graphs; we find that divided edge bundling leads to visualizations that are easier to interpret and reveal both familiar and previously obscured patterns.  相似文献   
66.
Blanchet-Sadri et al. have shown that Avoidability, or the problem of deciding the avoidability of a finite set of partial words over an alphabet of size k≥2, is NP-hard [F. Blanchet-Sadri, R. Jungers, J. Palumbo, Testing avoidability on sets of partial words is hard, Theoret. Comput. Sci. 410 (2009) 968-972]. Building on their work, we analyze in this paper the complexity of natural variations on the problem. While some of them are NP-hard, others are shown to be efficiently decidable. Using some combinatorial properties of de Bruijn graphs, we establish a correspondence between lengths of cycles in such graphs and periods of avoiding words, resulting in a tight bound for periods of avoiding words. We also prove that Avoidability can be solved in polynomial space, and reduces in polynomial time to the problem of deciding the avoidability of a finite set of partial words of equal length over the binary alphabet. We give a polynomial bound on the period of an infinite avoiding word, in the case of sets of full words, in terms of two parameters: the length and the number of words in the set. We give a polynomial space algorithm to decide if a finite set of partial words is avoided by a non-ultimately periodic infinite word. The same algorithm also decides if the number of words of length n avoiding a given finite set of partial words grows polynomially or exponentially with n.  相似文献   
67.
One of congress’ goals for 2007 was for 80% of all tax and informational returns to be filed electronically. However, to date that lofty goal has fallen well short. This research proposes a model of e-filing adoption. To test the model a survey is administered to 260 participants. The instrument assesses citizen perceptions of trust, risk and optimism bias. Structural equation modeling is used to evaluate the relationships between these three concepts and intention to use. The results indicate that trust of the Internet, trust of the e-filer, perceived risk and optimism bias all have an impact on intention to use e-filing. Implications for practice and research are discussed.  相似文献   
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69.
Hardware can play a significant role in improving reliability of multithreaded software. Recent architectural proposals arbitrarily group consecutive dynamic memory operations into atomic blocks to enforce coarse-grained memory ordering, providing implicit atomicity. The authors of this article observe that implicit atomicity probabilistically hides atomicity violations by reducing the number of interleaving opportunities between memory operations. They propose Atom-Aid, which creates implicit atomic blocks intelligently instead of arbitrarily, dramatically reducing the probability that atomicity violations will manifest themselves.  相似文献   
70.
Data envelopment analysis (DEA) is a performance measurement tool that was initially developed without consideration of the decision maker (DM)'s preference structures. Ever since, there has been a wide literature incorporating DEA with value judgements such as the goal and target setting models. However, most of these models require prior judgements on target or weight setting. This paper will establish an equivalence model between DEA and multiple objective linear programming (MOLP) and show how a DEA problem can be solved interactively without any prior judgements by transforming it into an MOLP formulation. Various interactive multiobjective models would be used to solve DEA problems with the aid of PROMOIN, an interactive multiobjective programming software tool. The DM can then search along the efficient frontier to locate the most preferred solution where resource allocation and target levels based on the DM's value judgements can be set. An application on the efficiency analysis of retail banks in the UK is examined. Comparisons of the results among the interactive MOLP methods are investigated and recommendations on which method may best fit the data set and the DM's preferences will be made.  相似文献   
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