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81.
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Shaked H Carmeli Y Schwartz D Siegman-Igra Y 《Scandinavian journal of infectious diseases》2006,38(11-12):995-1000
Enterococci are increasingly common nosocomial pathogens that can cause serious infections and often acquire antibiotic resistance. This study focused on the epidemiological, microbiological and clinical characteristics of enterococcal bacteraemia with special attention to the impact of high level gentamicin resistance (HLGR) on prognosis. 117 cases of enterococcal bacteraemia constituted 8% of all bacteraemic episodes during the y 2002. The most common source of infection was the urinary tract, more than half of the episodes were polymicrobial and the vast majority of cases was healthcare-associated. 50 of 117 isolates (43%) were resistant to gentamicin. Infection-related mortality (22 of 117, 19%) was associated with 2 independent variables in multivariate analysis: severity-of-illness score (OR=39.6, p<0.00001) and HLGR (OR=6.4, p=0.006). It was concluded that HLGR adversely affects the outcome of bacteraemic enterococcal infection. 相似文献
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Hila Emmert Franziska Rademacher Regine Gläser Jürgen Harder 《Experimental dermatology》2020,29(11):1133-1139
In the May issue of Experimental Dermatology 2018, we published a review article focusing on human 3D skin models in the context of microbiota research. The principal intention was to provide an overview of present and future concepts to use skin models in microbiota analyses. With the present viewpoint, we would like to draw the reader's attention again to the use of human skin models in microbiota research with the aim to highlight the benefits and necessity of human skin models to analyse the human skin-microbiota interaction. This is accompanied by a critical view on mice models that often are not suitable to analyse the functional impact of the human skin microbiota. In addition, we present novel and future concepts highlighting the benefits of human 3D skin models in microbiota research. 相似文献
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Avidan H Kipnis J Butovsky O Caspi RR Schwartz M 《European journal of immunology》2004,34(12):3434-3445
Neurodegenerative diseases differ in etiology but are propagated similarly. We show that neuronal loss caused by intraocular injection of aggregated beta-amyloid was significantly greater in immunodeficient mice than in normal mice. The neurodegeneration was attenuated or augmented by elimination or addition, respectively, of naturally occurring CD4(+)CD25(+) regulatory T cells (Treg). Vaccination with retina-derived antigens or with the synthetic copolymer glatiramer acetate (Copolymer-1, Cop-1), but not with beta-amyloid, reduced the ocular neuronal loss. In mouse hippocampal slices, microglia encountering activated T cells overcame the cytotoxicity of aggregated beta-amyloid. These findings support the concept of "protective autoimmunity", show that a given T cell-based vaccination is protective at a particular site irrespective of toxicity type, and suggest that locally activated T cells induce a microglial phenotype that helps neurons withstand the insult. Alzheimer's and other neurodegenerative diseases might be arrested or retarded by vaccination with Cop-1 or related compounds or by treatment with compounds that weaken Treg suppression. 相似文献
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Ben-Shlush I Volinsky R Katz M Scindia Y Itzhak R Ohayon HT Yosha I Jelinek R 《Pharmaceutical research》2008,25(12):2815-2821
Purpose To develop and demonstrate a rapid and simple colorimetric film assay for evaluating lipid interactions of pharmaceutical
compounds and gel formulations.
Methods The colorimetric assay comprises glass-supported films of phospholipids and polydiacetylene, which undergo visible and quantifiable
blue–red transformations induced by interactions with amphiphilic molecules applied in very small volumes on the film surface.
The color transitions are recorded by scanning of the films, and quantified through a simple image analysis algorithm.
Results We show that pharmaceutical molecules and gel formulations induce blue–red transformations after short incubation with the
lipid/polydiacetylene (PDA) films. Colorimetric dose–response curves exhibit dependence upon the lipid affinity and extent
of membrane binding of the pharmaceutical compounds examined. The colorimetric lipid/PDA film assay was employed for distinguishing
the contributions of individual molecular components within gel formulations.
Conclusions The colorimetric data yield insight into the degree of lipid binding of the molecules tested. The film assay is particularly
advantageous for analysis of semi-solid (gel or lotion) formulations, elucidating the lipid interaction characteristics of
specific molecular components within the mixtures. The new colorimetric film assay constitutes a generic, rapid, and easily
applicable platform for predicting and screening interactions of pharmaceutical compounds and complex formulations with lipid
barriers.
Izek Ben-Shlush and Roman Volinsky contributed equally. 相似文献
90.
Gal Tsaban Avital Bilitzky-Kopit Anat Yaskolka Meir Hila Zelicha Yftach Gepner Ilan Shelef Omri Orr Yoash Chassidim Benjamin Sarusi Uta Ceglarek Michael Stumvoll Matthias Blüher Meir J. Stampfer Iris Shai Dan Schwarzfuchs 《Nutrients》2021,13(11)
Accumulation of cervical and chin subcutaneous adipose tissues (SAT) represent known phenotypes of obesity. We aimed to evaluate the sensitivity of these fat storages to long-term weight-loss directed lifestyle-intervention and to assess their relations to bodily-adiposity, insulin-resistance, and cardiometabolic risk; We randomly assigned 278 participants with abdominal-obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets +/− physical-activity. All participants underwent an 18 month whole-body magnetic resonance imaging follow-up, from which we assessed cervical and chin SAT-areas; Participants (age = 48 years; 90% men; body-mass-index = 30.9 kg/m2) had an 18-month adherence-rate of 86%. Cervical-SAT and chin-SAT decreased after 6-months (−13.1% and −5.3%, respectively, p < 0.001). After 18-months only cervical-SAT remained decreased compared to baseline (−5%, p < 0.001). Cervical and chin-SAT 18-month changes were associated with changes in weight (r = 0.70, r = 0.66 respectively; <0.001 for both) and visceral-adipose-tissue (VAT; r = 0.35, r = 0.42 respectively; <0.001 for both). After adjustment to VAT, waist-circumference, or weight-changes, chin-SAT 18-month reduction was associated with favorable changes in fasting-glucose (β = 0.10; p = 0.05), HbA1c (β = 0.12; p = 0.03), and homeostasis-model-assessment-of-insulin-resistance (β = 0.12; p = 0.03). Cervical-SAT 18-month reduction was associated with decreased triglycerides (β = 0.16; p = 0.02) and leptin (β = 0.19; p = 0.01) independent of VAT; Cervical and chin-SATs are dynamic fat depots that correspond with weight-loss and are associated with changes in cardiometabolic profile. In long-term, chin-SAT displays a larger rebound compared with cervical-SAT. Chin-SAT accumulation is associated with in insulin-resistance, independent of central obesity. (ClinicalTrials identifier ) NCT01530724相似文献