全文获取类型
收费全文 | 2587676篇 |
免费 | 225883篇 |
国内免费 | 12711篇 |
学科分类
医药卫生 | 2826270篇 |
出版年
2022年 | 22596篇 |
2021年 | 54182篇 |
2020年 | 34578篇 |
2019年 | 57420篇 |
2018年 | 68805篇 |
2017年 | 52272篇 |
2016年 | 57611篇 |
2015年 | 72464篇 |
2014年 | 106469篇 |
2013年 | 171404篇 |
2012年 | 67658篇 |
2011年 | 63584篇 |
2010年 | 109375篇 |
2009年 | 116137篇 |
2008年 | 51421篇 |
2007年 | 51115篇 |
2006年 | 63475篇 |
2005年 | 59487篇 |
2004年 | 62037篇 |
2003年 | 53626篇 |
2002年 | 43838篇 |
2001年 | 58068篇 |
2000年 | 49107篇 |
1999年 | 58340篇 |
1998年 | 60143篇 |
1997年 | 59351篇 |
1996年 | 56981篇 |
1995年 | 52568篇 |
1994年 | 46733篇 |
1993年 | 43833篇 |
1992年 | 37518篇 |
1991年 | 35063篇 |
1990年 | 32481篇 |
1989年 | 32793篇 |
1988年 | 30613篇 |
1987年 | 29771篇 |
1986年 | 28398篇 |
1985年 | 29706篇 |
1984年 | 32117篇 |
1983年 | 30805篇 |
1982年 | 36033篇 |
1981年 | 34500篇 |
1980年 | 32617篇 |
1979年 | 24429篇 |
1978年 | 25400篇 |
1977年 | 24261篇 |
1976年 | 21900篇 |
1975年 | 19664篇 |
1974年 | 18241篇 |
1973年 | 17442篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
12.
Interstitial cystitis/bladder pain syndrome (IC/BPS) and vulvodynia are chronic pain syndromes that appear to be intertwined from the perspectives of embryology, pathology and epidemiology. These associations may account for similar responses to various therapies. 相似文献
13.
Hsiao-Hsuan Kuo Ran Fan Nina Dvorina Andres Chiesa-Vottero William M. Baldwin III 《Journal of the American Society of Nephrology : JASN》2015,26(4):855-863
Antibody-mediated rejection is a major complication in renal transplantation. The pathologic manifestations of acute antibody-mediated rejection that has progressed to functional impairment of a renal transplant have been defined in clinical biopsy specimens. However, the initial stages of the process are difficult to resolve with the unavoidable variables of clinical studies. We devised a model of renal transplantation to elucidate the initial stages of humoral rejection. Kidneys were orthotopically allografted to immunodeficient mice. After perioperative inflammation subsided, donor-specific alloantibodies were passively transferred to the recipient. Within 1 hour after a single transfer of antibodies, C4d was deposited diffusely on capillaries, and von Willebrand factor released from endothelial cells coated intravascular platelet aggregates. Platelet-transported inflammatory mediators platelet factor 4 and serotonin accumulated in the graft at 100- to 1000-fold higher concentrations compared with other platelet-transported chemokines. Activated platelets that expressed P-selectin attached to vascular endothelium and macrophages. These intragraft inflammatory changes were accompanied by evidence of acute endothelial injury. Repeated transfers of alloantibodies over 1 week sustained high levels of platelet factor 4 and serotonin. Platelet depletion decreased platelet mediators and altered the accumulation of macrophages. These data indicate that platelets augment early inflammation in response to donor-specific antibodies and that platelet-derived mediators may be markers of evolving alloantibody responses. 相似文献
14.
15.
Methicillin‐resistant Staphylococcus aureus eradication in young infants should include the diaper area and treat housing contacts 下载免费PDF全文
16.
17.
18.
19.
M. R. D. Maslin S. K. Lloyd S. Rutherford S. Freeman A. King D. R. Moore K. J. Munro 《Journal of the Association for Research in Otolaryngology》2015,16(5):631-640
Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in sub-cortical activity immediately before and after the onset of surgically induced unilateral deafness in adult humans. Click-evoked auditory brainstem responses (ABRs) to stimulation of the healthy ear were recorded from ten adults during the course of translabyrinthine surgery for the removal of a unilateral acoustic neuroma. This surgical technique always results in abrupt deafferentation of the affected ear. The results revealed a rapid (within minutes) reduction in latency of wave V (mean pre = 6.55 ms; mean post = 6.15 ms; p < 0.001). A latency reduction was also observed for wave III (mean pre = 4.40 ms; mean post = 4.13 ms; p < 0.001). These reductions in response latency are consistent with functional changes including disinhibition or/and more rapid intra-cellular signalling affecting binaurally sensitive neurons in the central auditory system. The results are highly relevant for improved understanding of putative physiological mechanisms underlying perceptual disorders such as tinnitus and hyperacusis. 相似文献
20.