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Rakowski Tomasz Siudak Zbigniew Dziewierz Artur Plens Krzysztof Kleczyński Paweł Dudek Dariusz 《Journal of thrombosis and thrombolysis》2018,45(1):151-157
Journal of Thrombosis and Thrombolysis - According to guidelines, it is recommended to give P2Y12 inhibitors (preferably ticagrelor or prasugrel) at the time of first medical contact in patients... 相似文献
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Validation of a semi‐automatic co‐registration of MRI scans in patients with brain tumors during treatment follow‐up 下载免费PDF全文
Anouk van der Hoorn Jiun‐Lin Yan Timothy J. Larkin Natalie R. Boonzaier Tomasz Matys Stephen J. Price 《NMR in biomedicine》2016,29(7):882-889
There is an expanding research interest in high‐grade gliomas because of their significant population burden and poor survival despite the extensive standard multimodal treatment. One of the obstacles is the lack of individualized monitoring of tumor characteristics and treatment response before, during and after treatment. We have developed a two‐stage semi‐automatic method to co‐register MRI scans at different time points before and after surgical and adjuvant treatment of high‐grade gliomas. This two‐stage co‐registration includes a linear co‐registration of the semi‐automatically derived mask of the preoperative contrast‐enhancing area or postoperative resection cavity, brain contour and ventricles between different time points. The resulting transformation matrix was then applied in a non‐linear manner to co‐register conventional contrast‐enhanced T1‐weighted images. Targeted registration errors were calculated and compared with linear and non‐linear co‐registered images. Targeted registration errors were smaller for the semi‐automatic non‐linear co‐registration compared with both the non‐linear and linear co‐registered images. This was further visualized using a three‐dimensional structural similarity method. The semi‐automatic non‐linear co‐registration allowed for optimal correction of the variable brain shift at different time points as evaluated by the minimal targeted registration error. This proposed method allows for the accurate evaluation of the treatment response, essential for the growing research area of brain tumor imaging and treatment response evaluation in large sets of patients. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Barbara Jasiewicz Jacek Pietraszek Sławomir Duda Szymon Pietrzak Błażej Pruszczyński Tomasz Parol Tomasz Potaczek Aneta Gądek-Moszczak 《Foot and Ankle Surgery》2021,27(4):371-376
BackgroundFoot bones in children have more rounded shapes in radiograms than adults. Thus, the goal of this work was assessing inter- and intra-observer reliability in paediatric forefoot angle measurements.Material and methodsSix forefoot angles in 34 AP standing paediatric foot radiographs were measured by 5 researchers. A classic statistical analysis with use of IBM SPSS Statistics 25 was performed and a new method with two-way analysis of variance was applied.ResultsResults of statistical analysis revealed the properties of a subjective assessment related to specific angles. Kilmartin’s angle, calcaneus-fifth metatarsal angle and first ray angle are the most reliable; metatarsus adductus angle should be used with great caution in pediatric population. Engel’s angle is the most difficult for measuring and measurement error is the highest.ConclusionThe power of paediatric forefoot measurements is various. Several angles are reliable, while Engle’s angle is the most doubtful. 相似文献
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Aleksander Ku Mikoaj Radziszewski Aleksandra Glina Konrad Szymaski Beata Jurecka‐Lubieniecka Edyta Pawlak‐Adamska Dorota Kula Natalia Wawrusiewicz‐Kurylonek Joanna Ku Piotr Mikiewicz Rafa Poski Marek Bolanowski Jacek Daroszewski Barbara Jarzb Artur Bossowski Tomasz Bednarczuk 《Clinical endocrinology》2019,90(2):320-327
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Jan Detka Joanna Ślusarczyk Anna Kurek Mateusz Kucharczyk Tomasz Adamus Paweł Konieczny Marta Kubera Agnieszka Basta-Kaim Władysław Lasoń Bogusława Budziszewska 《Pharmacological reports : PR》2019,71(2):338-346
Background
In depression, excessive glucocorticoid action may cause maladaptive brain changes, including in the pathways controlling energy metabolism. Insulin and glucagon-like peptide-1 (GLP-1), besides regulation of glucose homeostasis, also possess neurotrophic properties. Current study was aimed at investigating the influence of prenatal stress (PS) on insulin, GLP-1 and their receptor (IR and GLP-1R) levels in the hypothalamus. GLP-1 and GLP-1R were assayed also in the hippocampus and frontal cortex – brain regions mainly affected in depression. The second objective was to determine the influence of exendin-4 and insulin on CRH promoter gene activity in in vitro conditions.Methods
Adult male PS rats were subjected to acute stress and/or received orally glucose. Levels of hormones and their receptors were assayed with ELISA method. In vitro studies were performed on mHypoA-2/12?hypothalamic cell line, stably transfected with CRH promoter coupled with luciferase.Results
PS has reduced GLP-1 and GLP-1R levels, attenuated glucose-induced increase in insulin concentration and increased the amount of phosphorylated IR in the hypothalamus of animals subjected to additional stress stimuli, and also decreased the GLP-1R level in the hippocampus. In vitro studies demonstrated that insulin is capable of increasing CRH promoter activity in the condition of stimulation of the cAMP/PKA pathway in the applied cellular model.Conclusion
Prenatal stress may act as a preconditioning factor, affecting the concentrations of hormones such as insulin and GLP-1 in the hypothalamus in response to adverse stimuli. The decreased GLP-1R level in the hippocampus could be linked with the disturbances in neuronal plasticity. 相似文献60.