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91.
Matthew D Robson Peter D Gatehouse Graeme M Bydder Stefan Neubauer 《Magnetic resonance in medicine》2004,51(5):888-892
Phosphorus was imaged in vivo in human cortical and trabecular bone and the T(1) and T(2) (*) were measured. An ultrashort TE (UTE) pulse sequence (TE = 70 microm) was used with half pulse excitation and radial mapping of k-space from the center out. T(2) (*) was measured using multiple echo times and T(1) was measured both by saturation recovery and by a method using different RF pulse amplitudes. Seven normal subjects (32-85 years) were examined. Phosphorus was imaged, with a true in-plane resolution of 2.9 x 2.9 mm and a signal-to-noise ratio (SNR) of 19:1, in both cortical and trabecular bone. The mean T(2) (*) value was 207 +/- 12 micros, and the mean T(1) value was 8.6 +/- 3.0 sec. Images and measurements were obtained in realistic times on a clinical MR system. This may provide a new approach to characterizing disease of bone. 相似文献
92.
93.
Hoschek Stefan Hoschek-Risslegger Ursula Fiegl Michael Zabernigg August Pall Georg Auberger Thomas Gunsilius Eberhard Schmid Thomas Jamnig Herbert Hilbe Wolfgang 《Wiener Medizinische Wochenschrift》2007,157(21):562-568
Wiener Medizinische Wochenschrift - Aggressives Tumorwachstum, frühe Metastasierung und hohe Assoziation mit intensivem Nikotinkonsum sind die Charakteristika des kleinzelligen... 相似文献
94.
Stefan Tigges M.D. B. J. Manaster M.D. Ph.D. Gordon Carson M.D. 《Emergency radiology》1996,3(3):105-112
Although magnetic resonance imaging is the most accurate imaging method of evaluating the anterior cruciate ligament, several
plain radiographic signs suggestive of anterior cruciate ligament injury have been described. Plain radiographs also play
an important role in evaluating anterior cruciate ligament reconstruction. 相似文献
95.
Stefan Dinges 《Strahlentherapie und Onkologie》1998,174(7):386-387
Ohne Zusammenfassung 相似文献
96.
Stefan Somlo 《Clinical and experimental nephrology》1998,2(3):211-217
Conclusion The past decade has seen extraordinary progress in the study of autosomal-dominant polycystic kidney disease. The 2 major
genes for this disorder have been identified. Animal models of ADPKD have been produced. The molecular basis of the disease
has been characterized. ADPKD is a “second-hit” disease, much like many cancer predisposition syndromes. This has profound
implications for our understanding. The progression of ADPKD in individual patients is likely related more to their individual
rate of acquisition of second hits at thePKD1 orPKD2 locus than to the inherited germ line mutation itself. Therapeutic approaches will perhaps now be considered, which will
include interventions that may limit the rate at which somatic mutations occur in the kidney. The major focus of research
at present is to elucidate the normal functions ofPKD1 andPKD2. Protein binding partners are being sought for both proteins. The possible calcium channel function ofPKD2 is being investigated. The downstream effects of cellular deficiency of either protein are likely to yield many clues. Modifying
genetic factors that may independently affect disease progression are likely to be identified using the several mouse models.
Perhaps the next decade will bring great strides in understanding and in potential therapy for this common disease.
This paper was presented at the 2nd International Forum “The Frontiers of Nephrology,” Tokyo, May 10, 1998. 相似文献
97.
Thomas Lachmann Stefan Berti Teija Kujala Erich Schr?ger 《International journal of psychophysiology》2005,56(2):105-120
The present study addressed auditory processing in 8-11-year-old children with developmental dyslexia by means of event-related brain potentials (ERP). Cortical sound reception was evaluated by recording N250 responses to syllables and tones and cortical sound discrimination by analyzing the mismatch negativity (MMN) to syllable and tone changes. We found that both cortical sound reception and sound discrimination were impaired in dyslexic children. The analysis of the data obtained from two dyslexic subgroups, Dyslexics-1 being impaired in non-word reading (or both non-word and frequent word reading) and Dyslexics-2 in frequent word reading but not in non-word reading, revealed that the MMN was specifically diminished in the latter group whereas it was normal-like in Dyslexics-1. However, no differences were found between these subgroups in sound reception as indicated by the responses elicited by the standard stimuli. These results show that different diagnostic subgroups of dyslexics have different patterns of auditory processing deficits as suggested by similarly impaired sound reception in both dyslexic groups and the sound-discrimination impairment specific to one of the groups. 相似文献
98.
WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer 总被引:19,自引:0,他引:19
99.
100.
Dengjel J Decker P Schoor O Altenberend F Weinschenk T Rammensee HG Stevanovic S 《European journal of immunology》2004,34(12):3644-3651
T-helper (Th) cells play an important role in orchestrating the effector function of CTL in anti-tumor immunity. However, only a limited number of Th cell epitopes has been characterized. Here we describe a novel approach for identifying naturally processed and presented peptides derived from chosen antigens. This method combines a transfection step of antigen-presenting cells with a vector encoding a fusion protein between the Ii chain and the antigen of interest, elution of the HLA-bound peptides and identification of the antigen-derived peptides by mass spectrometric comparison to the non-transfected cells. In vitro-stimulated Th cells against the identified peptide of interest specifically recognize transfectants overexpressing the cognate antigen. Using this approach, we were able to identify the HLA-DR4-restricted Th cell epitope NPPSMVAAGSVVAAV derived from cyclin D1, which is frequently overexpressed in tumors. This method will help in identifying peptide candidates for vaccination studies for tumor immunotherapy. 相似文献