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11.
Srinivas SM de Boer JF Park H Keikhanzadeh K Huang HE Zhang J Jung WQ Chen Z Nelson JS 《Journal of biomedical optics》2004,9(1):207-212
An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 degrees C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/microm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients. 相似文献
12.
Patel Shyam Kakouri Agni Chaudhary Shweta Knepper Paul A. Pfahler Nicholas M. Samples John Giovingo Michael 《Lasers in medical science》2021,36(3):605-609
Lasers in Medical Science - To evaluate the effect of various media and Iridex MicroPulse P3 (MP3) probe angles on the power output from the Cyclo G6 Glaucoma Laser (G6) System. A laser power meter... 相似文献
13.
M. Karthik Selvaraj Tapan Kumar Das Nikhil Joseph Martin M. Shyam Sundar David V. Rajan 《Indian Journal of Orthopaedics》2021,55(3):723
IntroductionLatarjet procedure is commonly performed for recurrent anterior shoulder instability with glenoid side bone loss. Classic Latarjet procedure can be performed using specially designed drill guides, jigs, or by freehand technique. Here we have described a technical note on classic Latarjet procedure performed with freehand technique utilizing simple rulers and caliper. The functional and radiological outcomes of our patients have also been analysed.Material and Methods149 open classic Latarjet procedures were performed using our technique between March 2015 and July 2018. The mean age of the patients was 32.95 years (Range 22–59 years). The functional outcome of the patients was measured using Western Ontario Shoulder Instability (WOSI) and Oxford Shoulder Instability Score (OSIS) at 2 years of follow-up. Screw and graft positioning were studied in 24 consecutive patients with a postoperative computed tomography (CT) scan.ResultsThere was no incidence of recurrent subluxation or dislocation post-surgery. Mean OSIS score increased from 15.63 ± 3.20 preoperatively to 42.44 ± 3.88 postoperatively (p value < 0.05). WOSI score decreased significantly from 62.54% ± 8.24 to 10.26 ± 6.33 postoperatively at 2-year follow-up (p value < 0.05). Postoperative CT scan also showed satisfactory screw placement in all patients.ConclusionOpen Latarjet procedure performed using freehand technique provides good functional and radiological outcomes in patients with recurrent anterior shoulder instability with glenoid side bone loss.Supplementary InformationThe online version contains supplementary material available at 10.1007/s43465-021-00385-7. 相似文献
14.
Marion G. Peters Shyam Kottilil Norah Terrault Dominic Amara Jennifer Husson Shirish Huprikar Sander Florman Mark S. Sulkowski Christine M. Durand Anne F. Luetkemeyer Rodney Rogers Joshua Grab Brandy Haydel Emily Blumberg Lorna Dove Jean Emond Kim Olthoff Coleman Smith Thomas Fishbein Henry Masur Peter G. Stock 《American journal of transplantation》2021,21(5):1780-1788
Direct-acting antiviral (DAA) therapy has transformed the management of human immunodeficiency virus (HIV) and hepatitis C (HCV) coinfected patients with advanced liver disease. STOP-Coinfection was a multicenter prospective and retrospective, open-label study using sofosbuvir-based DAA therapy to treat HIV/HCV-coinfected participants pre– or post–liver transplant (LT). Sixty-eight participants with end-stage liver disease (Child-Turcotte-Pugh score ≥7 and Model for End-Stage Liver Disease score 6–29) were enrolled, 26 had hepatocellular carcinoma. Forty-two participants were treated pre–LT and 26 post–LT. All participants completed therapy without need for dose reduction or transfusion; eight required two or more courses of therapy. Ninety-three percent achieved a sustained virologic response and DAA therapy was well tolerated. Despite HCV cure, 12 end-stage liver disease participants required subsequent LT, 7 for decompensated liver disease. Thirteen participants died, 10 with decompensated liver disease pre–LT and three post–LT. Overall, transplant free survival was 42.8% at 4 years and post–LT survival was 87.9% at 5 years. We conclude that sofosbuvir-based DAA therapy is safe and highly effective in HCV-HIV patients with decompensated liver disease and post–LT, with post–LT survival rates comparable to other indications. This removes one of the last barriers to liver transplantation in this challenging cohort of recipients. 相似文献
15.
Patton Daniella Ghosh Adarsh Farkas Amy Sotardi Susan Francavilla Michael Venkatakrishna Shyam Bose Saurav Ouyang Minhui Huang Hao Davidson Richard Sze Raymond Nguyen Jie 《Journal of digital imaging》2023,36(4):1419-1430
Journal of Digital Imaging - Measurement of angles on foot radiographs is an important step in the evaluation of malalignment. The objective is to develop a CNN model to measure angles on... 相似文献
16.
17.
Value of antenatal echocardiography in high risk patients to diagnose congenital cardiac defects in fetus 总被引:3,自引:0,他引:3
Results of fetal echocardiography in 1062 high risk pregnant patients are described. It was performed before 28 weeks of gestation
in 770 cases. These were 38 abnormal scans (3.6%). A fetal arrhythmia was diagnosed in 14 cases and structural abnormality
of the heart in 24. Complete atrioventricular block was commonest (n=12), structural heart disease associated in two of these
cases. Other lesions identified were atrioventricular septal defect (n=5), hypoplastic left heart syndrome (n=4), ventricular
septal defect (n=4), Ebstein’s anomaly (n=3), coarctation of aorta (n=2) and others (n=9). Postnatal confirmatory echocardiography
is available in a total of 993 babies including 36 of 38 abnormal cases. There were eleven neonatal deaths amongst babies
with abnormal scans. Errors in interpretation were observed in six instances. An anomaly was missed in five cases; in two
of these, the main cardiac malformation was picked up but secondary lesions were missed. In one case, a false positive diagnosis
of atrial septal defect was made. These errors did not influence the management of the pregnancy.
Fetal echocardiography is a very sensitive (91.6%) and specific (99.9%) tool for antenatal diagnosis of congenital heart disease
in high risk pregnancies. The information so obtained helps in guiding the optimal obstetric and neonatal management of these
cases. 相似文献
18.
Shyam K Penketh PG Shapiro M Belcourt MF Loomis RH Rockwell S Sartorelli AC 《Journal of medicinal chemistry》1999,42(5):941-946
Some 4- and 2-(nitrobenzyloxycarbonyl)-1, 2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines (4, 6, and 7) were synthesized and evaluated for their ability to exert preferential toxicity to hypoxic EMT6 mammary carcinoma cells using a colony-forming assay. Of these, the 4,5-dimethoxy-2-nitro analogue 6 (50 microM, 1-h exposure) caused greater than 3 logs of kill of hypoxic cells, with relatively minor toxicity to corresponding aerobic cells. The ability of 4-nitro (4) and 4,5-dimethoxy-2-nitro (6) analogues to reach and kill hypoxic cells of solid tumors was also demonstrated using intradermally implanted EMT6 solid tumors in mice. In addition, a possible source of toxicity to normal tissue, i. e., the activation of the 4-nitrobenzyl derivative 4 by glutathione S-transferase-catalyzed thiolysis, was essentially eliminated by replacing one of the benzylic methylene protons by a methyl group. The 4-nitro (4) and 4,5-dimethoxy-2-nitro (6) analogues also appear to be reduced more easily under acidic conditions (pH 6.0) than under neutral conditions, as measured by differential pulse polarography. Since the pH in hypoxic regions is often lower than that in adjacent aerobic regions, this property should aid in the cytotoxic action of these agents against hypoxic cells of solid tumors. 相似文献
19.
Endoscopic ultrasonography is not required for staging malignant esophageal strictures that preclude the passage of a diagnostic gastroscope
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