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991.
Javier Martínez Trufero Jaume Capdevilla Juan Jesús Cruz Dolores Isla 《Clinical & translational oncology》2011,13(8):574-579
Although thyroid cancer represents less than 1% of malignant tumours, its increased incidence detected in recent years and
the appearance and development of new drugs targeting specific molecular targets has attracted the attention of the doctors
involved in this pathology, especially medical oncologists. For this reason it is important at this critical point, when treatment
may be substantially changed, to establish and agree updated guidelines. These guidelines should incorporate the newly developed
strategies that, although still preliminary in evidence level, will surely have an important role, especially in relapsed
and refractory tumours, which are unsuitable for surgical or radio-iodine treatment. Particular histological and molecular
features of these tumours must be taken into account in order to optimise therapeutic approaches. 相似文献
992.
The insulin-like growth factor (IGF) pathway plays an important role in cancer development, survival, metastasis, and resistance
to antineoplastic therapies in various malignancies. Components of the IGF pathway are potential targets for novel anticancer
therapy. In breast cancer, preclinical and clinical data suggest that IGF signaling is critical for tumor growth and resistance
to therapy, leading to poor prognosis. There is also evidence of cross-talk between IGF, estrogen, erbB, and mTOR pathways;
a potential mechanism of cancer resistance to hormonal or HER2-targeted therapy. This review discusses the rationale and strategies
being evaluated in the clinical development of targeting the IGF pathway. It highlights the potential interactions between
the IGF pathway and other therapies in breast cancer, and also focuses on the completed and ongoing clinical trials of different
IGF pathway–targeted therapies in breast cancer. 相似文献
993.
Objective: To explore the relationship between cytochrome P450 2E1 (CYP2E1) RsaI/PstI and DraI polymorphism and lung cancer susceptibility in Mongolian and Han population in Inner Mongolia of China. Methods: CYP2E1 RsaI/PstI and DraI polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 64 lung cancer patients, 150 healthy Mongolian and 150 healthy Han individuals. The distribution of genotype and allele frequencies of CYP2E1 RsaI/PstI and DraI polymorphisms we... 相似文献
994.
Deviprasad Shetty Rajeshwari Aroor K. S. Gangadhara Somayaji Mohammed Tahir N. A. Mohammad 《Indian journal of otolaryngology and head and neck surgery》2011,63(1):16-18
Sinonasal lymphomas are aggressive locally destructive midfacial necrotizing lesions. Most of them initially diagnosed as lethal midline granulomas, a term which is slowly replaced by sinonasal lymphoma. Here is one such case report of sinonasal T cell lymphoma where there was a difficulty in diagnosis and required an incisional biopsy. 相似文献
995.
Background
Longitudinal studies are of aetiological and public health relevance but can be undermined by attrition. The aim of this paper was to identify effective retention strategies to increase participation in population-based cohort studies. 相似文献996.
Hsu-Heng Yen Yang-Yuan Chen Chia-Wei Yang Maw-Soan Soon 《Digestive diseases and sciences》2010,55(12):3473-3478
Background
Jejunal diverticular disease is a rare cause of gastrointestinal bleeding. The reported incidence of this disease is low in the studies of double-balloon enteroscopy. 相似文献997.
Abigail A. Fagan Michael W. Arthur Koren Hanson John S. Briney J. David Hawkins 《Prevention science》2011,12(3):223-234
This paper describes findings from the Community Youth Development Study (CYDS), a randomized controlled trial of the Communities
That Care (CTC) prevention system, on the adoption and implementation fidelity of science-based prevention programming in
24 communities. Data were collected using the Community Resource Documentation (CRD), which entailed a multi-tiered sampling
process and phone and web-based surveys with directors of community-based agencies and coalitions, school principals, service
providers, and teachers. Four years after the initiation of the CTC prevention system, the results indicated increased use
of tested, effective prevention programs in the 12 CTC intervention communities compared to the 12 control communities, and
significant differences favoring the intervention communities in the numbers of children and families participating in these
programs. Few significant differences were found regarding implementation quality; respondents from both intervention and
control communities reported high rates of implementation fidelity across the services provided. 相似文献
998.
Karen L. Noblett 《International urogynecology journal》2010,21(2):461-466
Electrodiagnostic techniques have been utilized in surgery since the early 1960s. These techniques have been primarily used in neurosurgery; however, with the introduction of neuromodulation for voiding dysfunction, these techniques have now found their way into the field of female pelvic medicine. This article will review techniques applicable to evaluate pelvic floor function as it relates to neuromodulation. It will also review the literature describing how these techniques are used to help determine appropriate candidates as well as improve surgical outcomes. A PubMed search was conducted using the terms neuromodulation, Interstim, electrodiagnosis, electrodiagnostic techniques, electromyography with limits to the pelvic floor, and voiding dysfunction. Eight articles and three abstracts were found that directly related to the use of electrodiagnostic techniques as they apply to neuromodulation. Electrodiagnostic techniques may play a role in helping predict appropriate candidates for neuromodulation as well as improve surgical outcomes. 相似文献
999.
1000.
M. Patrick Lowe Saurabh Kumar Peter R. Johnson Scott A. Kamelle Donald H. Chamberlain Todd D. Tillmanns 《Journal of robotic surgery》2010,4(2):109-115
The primary aim of this article is to report the outcomes of octogenarians and nonagenarians who have undergone robotic surgery
for endometrial cancer. A multi-institutional research consortium was created to evaluate the utility of robotics for gynecologic
surgery (benign and malignant). IRB approval was obtained at each institution. A multi-institutional HIPPA compliant database
was then created and analyzed for all patients that underwent robotic-assisted surgery with staging for endometrial cancer
between the April 2003 and January 2009. In total, 395 patients were identified. A subset of patients between the ages of
80 and 95 years were then identified and analyzed for demographic data and perioperative outcomes. Twenty-seven patients in
this age group were identified who underwent robotic-assisted hysterectomy and staging. The median age was 84, and median
body mass index was 28. Comorbidities such as diabetes mellitus and hypertension were identified in 22 and 74% of patients,
respectively. Over one-half (56%) of the patients reported a prior abdominal surgery. Final pathological analysis demonstrated
that 88% of all patients had either Stage I or II disease. The median operative time was 192 min. The median estimated blood
loss was 50 cc, and the median lymph node count was 16. The median hospital stay was 1.0 day. The overall intraoperative and
postoperative complication rate was 7.4 and 33%, respectively. No patient received a blood transfusion. There was one conversion
to laparotomy (3.7%). A comparison of the outcomes of the elderly cohort to those of all patients in the database (control
group) revealed that there was no statistically significant difference between the groups in terms of operative time, blood
loss, hospital stay, nodal yield, or conversion rate. Intraoperative complications were statistically similar between the
groups; however, postoperative complications were significantly higher in the elderly cohort. We conclude that robotic surgery
is safe, feasible, and expands surgical options for octogenarians and nonagenarians diagnosed with endometrial cancer. Age
should not be considered a contraindication for robotic surgical management of patients with endometrial cancer. 相似文献