全文获取类型
收费全文 | 2881篇 |
免费 | 186篇 |
国内免费 | 8篇 |
学科分类
医药卫生 | 3075篇 |
出版年
2023年 | 18篇 |
2022年 | 22篇 |
2021年 | 76篇 |
2020年 | 58篇 |
2019年 | 55篇 |
2018年 | 79篇 |
2017年 | 62篇 |
2016年 | 62篇 |
2015年 | 72篇 |
2014年 | 100篇 |
2013年 | 112篇 |
2012年 | 180篇 |
2011年 | 193篇 |
2010年 | 108篇 |
2009年 | 77篇 |
2008年 | 163篇 |
2007年 | 166篇 |
2006年 | 130篇 |
2005年 | 132篇 |
2004年 | 127篇 |
2003年 | 85篇 |
2002年 | 75篇 |
2001年 | 64篇 |
2000年 | 64篇 |
1999年 | 61篇 |
1998年 | 23篇 |
1997年 | 14篇 |
1996年 | 20篇 |
1993年 | 14篇 |
1992年 | 40篇 |
1991年 | 47篇 |
1990年 | 38篇 |
1989年 | 39篇 |
1988年 | 47篇 |
1987年 | 35篇 |
1986年 | 34篇 |
1985年 | 17篇 |
1984年 | 23篇 |
1983年 | 15篇 |
1982年 | 14篇 |
1981年 | 19篇 |
1979年 | 30篇 |
1977年 | 15篇 |
1975年 | 14篇 |
1974年 | 17篇 |
1973年 | 28篇 |
1972年 | 35篇 |
1971年 | 16篇 |
1970年 | 27篇 |
1967年 | 13篇 |
排序方式: 共有3075条查询结果,搜索用时 15 毫秒
51.
Questionnaires were distributed among 200 medical students regarding safety precautions observed while perfonning various invasive procedures during their clinical posting. Only 106 students responded with the completed questionnaire. The most common procedure performed by the students was drawing of blood, with an average frequency of 60.8 per month. Sixty-one per cent of the students reported being injured during the various procedures and only 3 5.5% of them used gloves. Resheathing the needle was responsible for causing injury to 69% of the students, which was significantly higher than injuries occurring while entry into the vein or withdrawing the needle (p<0.05). 相似文献
52.
Three-dimensional gadolinium-enhanced MR angiography of vascular complications after liver transplantation 总被引:17,自引:0,他引:17
Glockner JF Forauer AR Solomon H Varma CR Perman WH 《AJR. American journal of roentgenology》2000,174(5):1447-1453
OBJECTIVE: The goal of this study was to evaluate three-dimensional gadolinium-enhanced MR angiography as a tool for examination of liver transplant patients with potential vascular complications. MATERIALS AND METHODS: Thirty-eight consecutive three-dimensional gadolinium-enhanced MR angiograms were obtained in 34 patients. Results were retrospectively reviewed and correlated with conventional angiography in 20 of the 38 cases and sonography in 37 of the 38 cases. MR angiograms were evaluated for technical adequacy, vascular patency, and parenchymal abnormalities, and results were compared with angiography and sonography. Conventional angiography and surgery were used as gold standards when available. RESULTS: Thirty-four (90%) of 38 MR angiograms were technically adequate. Vascular abnormalities were identified in 20 patients, and 19 of these patients subsequently underwent angiography, surgery, or both. There were seven cases of hepatic artery thrombosis; all were detected with MR angiography with no false-positive or false-negative interpretations. Seven patients had moderate to severe hepatic artery stenosis (>50% narrowing as determined by conventional angiography). MR angiography revealed this stenosis in six of the seven patients, with one false-negative and three false-positive interpretations. Portal vein thrombosis was detected in three patients, and portal vein stenosis was detected in two patients. CONCLUSION: Three-dimensional gadolinium-enhanced MR angiography is useful in the examination of liver transplant patients and offers a noninvasive adjunct in patients with difficult or indeterminate sonographic examinations. 相似文献
53.
Manthena V.S. Varma Ramesh Panchagnula 《European journal of pharmaceutical sciences》2005,25(4-5):445-453
Solubility and permeability being important determinants of oral drug absorption, this study was aimed to investigate the effect of d--tocopheryl polyethylene glycol 1000 succinate (TPGS) on the solubility and intestinal permeability of paclitaxel in vitro, in situ and in vivo, in order to estimate the absorption enhancement ability of TPGS. Aqueous solubility of paclitaxel is significantly enhanced by TPGS, where a linear increase was demonstrated above a TPGS concentration of 0.1 mg/ml. Paclitaxel demonstrated asymmetric transport across rat ileum with significantly greater (26-fold) basolateral-to-apical (B–A) permeability than that in apical-to-basolateral (A–B) direction. Presence of P-glycoprotein (P-gp) inhibitor, verapamil (200 μM), diminished asymmetric transport of paclitaxel suggesting the role of P-gp-mediated efflux. TPGS showed a concentration-dependent increase in A–B permeability and decreased B–A permeability. The maximum efflux inhibition activity was found at a minimum TPGS concentration of 0.1 mg/ml, however, further increase in TPGS concentration resulted in decreased A–B permeability with no change in B–A permeability. Thus, the maximum paclitaxel permeability attained with 0.1 mg/ml TPGS was attributed to the interplay between TPGS concentration dependent P-gp inhibition activity and miceller formation. In situ permeability studies in rats also demonstrated the role of efflux in limiting permeability of paclitaxel and inhibitory efficiency of TPGS. The plasma concentration of [14C]paclitaxel following oral administration (25 mg/kg) was significantly increased by coadministration of TPGS at a dose of 50 mg/kg in rats. Bioavailability is enhanced about 4.2- and 6.3-fold when [14C]paclitaxel was administrated with verapamil (25 mg/kg) and TPGS, respectively, as compared to [14C]paclitaxel administered alone. The effect of verapamil on oral bioavailability of [14C]paclitaxel was limited relative to the TPGS, consistent with the in vitro solubility and permeability enhancement ability of TPGS. In conclusion, the current data suggests that the coadministration of TPGS may improve the bioavailability of BCS class II–IV drugs with low solubility and/or less permeable as a result of significant P-gp-mediated efflux. 相似文献
54.
Bangkim Chandra Khangembam MD Niraj Naswa MD Punit Sharma MD Chandrasekhar Bal MD Arun Malhotra MD PhD Rakesh Kumar MD PhD 《Journal of nuclear cardiology》2012,19(5):1078-1079
We present an interesting image that demonstrates utility of 68Ga-DOTANOC PET/CT for demonstrating rare metastatic sites of neuroendocrime tumor. 相似文献
55.
Niraj K. Tripathi A. Eric Schultze Renee C. Pearson Nancy E. Everds Glenn S. Elliott Lila Ramaiah Monique Y. Wells Kenneth S. Latimer Gail L. Walter Paula Katavolos Nathanial D. Collins Jacqueline Tarrant Dana B. Walker Michael J. Topper Holly L. Jordan Laurie G. O’Rourke Valerie B. Guilpin Charles W. Brockus Jeffrey E. McCartney 《Experimental and toxicologic pathology》2013,65(1-2):39
56.
57.
Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists
下载免费PDF全文
![点击此处可从《Histopathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Charlotte F Kweldam Daan Nieboer Ferran Algaba Mahul B Amin Dan M Berney Athanase Billis David G Bostwick Lukas Bubendorf Liang Cheng Eva Compérat Brett Delahunt Lars Egevad Andrew J Evans Donna E Hansel Peter A Humphrey Glen Kristiansen Theodorus H van der Kwast Cristina Magi‐Galluzzi Rodolfo Montironi George J Netto Hemamali Samaratunga John R Srigley Puay H Tan Murali Varma Ming Zhou Geert J L H van Leenders 《Histopathology》2016,69(3):441-449
58.
59.
Nuri Ilker Akkus Faisal Bahadur Jai Varma 《Cardiovascular Revascularization Medicine》2013,14(1):41-44
Peripheral arterial lesions are usually longer than coronary artery lesions and require longer balloons and stents. Theoretically while advancing a long balloon in a long, high grade lesion with aggressive manipulation, the balloon can twist inside the lesion, but this has not been described before in the literature. Herein we are reporting a case where peripheral balloon (PB) twisted and appeared as a non-dilating lesion. 相似文献
60.
Kamalika Roy Richard Balon Varma Penumetcha B. Harrison Levine 《Current psychiatry reports》2014,16(11):1-7
Bipolar disorder is associated with high mortality, and people with this disorder on average may die 10–20 years earlier than the general population. This excess and premature mortality continues to occur despite a large and expanding selection of treatment options dating back to lithium and now including anticonvulsants, antipsychotics, and evidence-based psychotherapies. This review summarizes recent findings on mortality in bipolar disorder, with an emphasis on the role of suicide (accounting for about 15 % of deaths in this population) and cardiovascular disease (accounting for about 35–40 % of deaths). Recent care models and treatments incorporating active outreach, integrated mental and physical health care, and an emphasis on patient self-management have shown promise in reducing excess mortality in this population. 相似文献