全文获取类型
收费全文 | 1259篇 |
免费 | 106篇 |
国内免费 | 8篇 |
学科分类
医药卫生 | 1373篇 |
出版年
2024年 | 3篇 |
2023年 | 36篇 |
2022年 | 65篇 |
2021年 | 98篇 |
2020年 | 71篇 |
2019年 | 65篇 |
2018年 | 91篇 |
2017年 | 41篇 |
2016年 | 63篇 |
2015年 | 60篇 |
2014年 | 55篇 |
2013年 | 73篇 |
2012年 | 101篇 |
2011年 | 97篇 |
2010年 | 61篇 |
2009年 | 46篇 |
2008年 | 52篇 |
2007年 | 55篇 |
2006年 | 52篇 |
2005年 | 36篇 |
2004年 | 31篇 |
2003年 | 36篇 |
2002年 | 21篇 |
2001年 | 5篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1995年 | 6篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1970年 | 1篇 |
1964年 | 1篇 |
1959年 | 1篇 |
1947年 | 1篇 |
1942年 | 1篇 |
1939年 | 2篇 |
1938年 | 1篇 |
1935年 | 1篇 |
1933年 | 2篇 |
1932年 | 1篇 |
1930年 | 1篇 |
1925年 | 2篇 |
1920年 | 1篇 |
1918年 | 1篇 |
1914年 | 1篇 |
1912年 | 1篇 |
1911年 | 1篇 |
1910年 | 2篇 |
1904年 | 1篇 |
排序方式: 共有1373条查询结果,搜索用时 15 毫秒
101.
102.
Mathilde Neuville Dominique Grisoli Alexane Nicoud Alexis Jacquier Jean-Christophe Lagier Frédéric Collart Pascal Thomas Philippe Parola 《The American journal of tropical medicine and hygiene》2010,83(1):102-103
We report a case of an adult who developed superior vena cava syndrome because of cardiac hydatidosis. A 37-year-old man from Morocco developed progressive dyspnoea and cough. Cardiac hydatidosis was diagnosed because of both the typical radiological findings and the positive serology for echinococcosis. The patient was treated by surgery and albendazole without complications. 相似文献
103.
PURPOSE OF REVIEW: Health-related quality-of-life studies are now recognized as critical to understand the burden of disease and treatments on patients' well being. Significant advances have been recently achieved in gastrointestinal cancers, including the development and clinical use of new robust quality-of-life instruments. We review recent literature to evaluate whether quality-of-life assessment contributes to optimal patient information and helps treatment choices. RECENT FINDINGS: Treatments of gastrointestinal cancers have changed in the last few years with increasing use of multimodal therapies and advances in surgical techniques, especially for low-lying rectal cancers. Concurrent to the development of sphincter-saving procedures, however, the long-term consequences of a permanent stoma on quality of life have been debated. Results of new palliative treatments should also be considered looking at preservation or improvement of quality of life and not only prolongation of life. SUMMARY: Gastrointestinal malignancies impact strongly on patient quality of life due to the aggressiveness of the treatments. Short-term negative effects of surgery and specific deficits in survivors were recently described in gastrointestinal cancers. Baseline quality-of-life data predict length of survival in hepatocarcinoma and metastatic colorectal cancer. Generally, quality-of-life results help to fully inform the patients of the advantages or disadvantages of therapeutic options, including adjuvant and palliative treatments. 相似文献
104.
Wikehult B Hedlund M Marsenic M Nyman S Willebrand M 《Journal of clinical nursing》2008,17(14):1923-1929
Aim and objective. To assess recollection of negative emotional experiences during burn care. Background. Patients in intensive care frequently report negative emotional experiences. Patients with severe burns who are treated in intensive care units undergo painful care procedures, but there have been no recent evaluations of their care experiences. Design. Former burn patients (n = 42) were randomly assigned to three groups: postal questionnaire, telephone interview and face‐to‐face interview. Methods. Assessments included negative care experiences (feelings of uncertainty, powerlessness, being afraid, insecure, being a nuisance, or neglected), severity of injury, patient satisfaction, personality traits and psychological symptoms. Results. Overall, the degree of recalled negative experiences was low and associated with greater severity of injury, more symptoms of post‐traumatic stress disorder and lower satisfaction with care. The feeling of powerlessness was the most common, as 67% of participants had such feelings to some extent. Conclusions. Overall, negative care experiences were uncommon and most prevalent among the severely injured. Such experiences were also associated with psychological symptoms and lower patient satisfaction. Relevance to clinical practice. Although relatively uncommon, negative emotional care experiences should be monitored more closely during care. 相似文献
105.
D Taussig G Dorfmüller M Fohlen C Jalin C Bulteau S Ferrand-Sorbets M Chipaux O Delalande 《Seizure》2012,21(8):631-638
PurposeIn children with drug-resistant focal epilepsy who are candidates for surgery, invasive exploration is sometimes required. However, this is being controversially discussed for children younger than 3 years. The question of its necessity, feasibility and its risks is often raised, since it concerns primarily lesional epilepsy and a lesionectomy might be proposed right away. However, this attitude does not take into account the specificities of epilepsy at this age, including poor specificity of electroclinical semiology and the ongoing myelination challenging the interpretation of magnetic resonance imaging (MRI).MethodsWe retrospectively studied the records of children with drug-resistant epilepsy who were younger than 3 years of age at the time of their invasive exploration at our institution from 2000 to 2009. We reviewed the clinical, imaging and electrophysiological data, and included post-operative outcome for those who underwent surgery.Key findings26 Children met the inclusion criteria. All had drug-resistant epilepsy that started at an average of 5.2 months (range 0–20 months) with multiple daily seizures in all and developmental delay in 16. The average age at the time of exploration was 21.8 months (range 5–35). In 20 children, subdural electrodes in combination with two or three depth electrodes were implanted, and in six children aged over 2 years a stereo-electro-encephalography (SEEG) was performed. SEEG was considered technically difficult to achieve before the age of 2 years. The tolerance of invasive exploration was good with a 3% morbidity consisting of one subdural hematoma during exploration by subdural electrodes, evacuated without any particular sequelae. In 25 patients, the exploration permitted to propose a focal resection. The surgical intervention was in the frontal lobe in 12 cases, the parietal lobe in six, the occipital lobe in two patients, and the temporal lobe in one child who underwent an additional resection. Four children had a resection of two or three lobes. Five underwent a second surgery, following a second invasive exploration. Histologically, the resected tissue revealed focal cortical dysplasia in 21 cases (including three patients with tuberous sclerosis), two post-ischemic lesions, one dysembryoplastic neuroepithelial tumor, and one gangliglioma associated with dysplasia. The mean postoperative follow-up period was 51 months (range 4–110). For the children operated on twice, follow-up was counted from the second surgery on. Seventeen children (68%) had an outcome of Engel class 1. In five (20%), seizure frequency was significantly improved (Engel class 3). In two of three patients without improvement in seizure frequency (Engel class 4), a new SEEG is planned and the third is presently a candidate for hemispherotomy.SignificanceInvasive exploration is feasible, well tolerated and carries a low morbidity in children under 3 years of age. At this age, it is indicated for drug-resistant lesional epilepsy associated with developmental delay. It permits delineating the lesion, which is not possible with MRI. The choice of the technique is in part age-dependent. The discussion of its indication arises in the same way as in the older child. 相似文献
106.
Fauconnier M Bourigault ML Meme S Szeremeta F Palomo J Danneels A Charron S Fick L Jacobs M Beloeil JC Ryffel B Quesniaux VF 《The American journal of pathology》2011,178(1):212-221
Cerebral malaria is the most severe neurologic complication in children and young adults infected with Plasmodium falciparum. T-cell activation is required for development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (CM). To characterize the T-cell activation pathway involved, the role of protein kinase C-theta (PKC-θ) in experimental CM development was examined. PKC-θ-deficient mice are resistant to CM development. In the absence of PKC-θ, no neurologic sign of CM developed after blood stage PbA infection. Resistance of PKC-θ-deficient mice correlated with unaltered cerebral microcirculation and absence of ischemia, as documented by magnetic resonance imaging and magnetic resonance angiography, whereas wild-type mice developed distinct microvascular pathology. Recruitment and activation of CD8(+) T cells, and ICAM-1 and CD69 expression were reduced in the brain of resistant mice; however, the pulmonary inflammation and edema associated with PbA infection were still present in the absence of functional PKC-θ. Resistant PKC-θ-deficient mice developed high parasitemia, and died at 3 weeks with severe anemia. Therefore, PKC-θ signaling is crucial for recruitment of CD8(+) T cells and development of brain microvascular pathology resulting in fatal experimental CM, and may represent a novel therapeutic target of CM. 相似文献
107.
Jana Schwartz Claudia Drossard Katharina Dube Frank Kannenberg Clemens Kunz Hermann Kalhoff Mathilde Kersting 《European journal of nutrition》2010,49(3):189-195
Background
The breastfed infant is usually used as standard for formula feeding, also regarding long-chain polyunsaturated fatty acids (LC-PUFA). Here, plasma fatty acid concentrations in formula fed infants and the effects of LC-PUFA supplementation were investigated under real-life conditions. 相似文献108.
109.
This work reviews available data on dietary intakes of total fat, saturated fatty acids (SFA) and individual polyunsaturated fatty acids (PUFA) in children in different countries worldwide and for the first time, compares them with recent international recommendations. Studies published before June 2021 reporting total fat, total SFA and individual PUFA intakes in children aged 1–7 y were included. Observed intakes were evaluated against FAO/WHO and EFSA recommendations. 65 studies from 33 countries were included. Fat intake was too low in 88% of studies in young children (1–3 y). SFA intake was >10%E in 69–73% of children, especially in Europe. Linoleic acid intake was <3%E in 24% of studies in 1–2 y olds and within FAO/WHO recommendations among all other ages. Alpha-linolenic acid intake was <0.5%E in almost half of studies. Docosahexaenoic acid (DHA) or eicosapentaenoic acid + DHA intakes were below recommendations in most studies. In summary, while total fat intake was too low among younger children, SFA intake was above, especially in Europe and n-3 PUFA intake, especially DHA, were below recommendations for all ages. Intake of n-3 PUFA, especially DHA, is generally suboptimal. More data, particularly from developing countries, are required to refine these findings and guide implementation of adapted nutrition policies. 相似文献
110.
François-Pierrick Desgranges Etienne Javouhey Carmine Mottolese Anne Migeon Alexandru Szathmari Florent Baudin Mathilde de Queiroz Bérengère Cogniat Dominique Chassard 《Child's nervous system》2014,30(8):1393-1398