全文获取类型
收费全文 | 156656篇 |
免费 | 11503篇 |
国内免费 | 1730篇 |
学科分类
医药卫生 | 169889篇 |
出版年
2023年 | 961篇 |
2022年 | 1750篇 |
2021年 | 3559篇 |
2020年 | 2209篇 |
2019年 | 3031篇 |
2018年 | 3676篇 |
2017年 | 2797篇 |
2016年 | 2841篇 |
2015年 | 3610篇 |
2014年 | 5099篇 |
2013年 | 7072篇 |
2012年 | 10337篇 |
2011年 | 10944篇 |
2010年 | 6331篇 |
2009年 | 5631篇 |
2008年 | 9433篇 |
2007年 | 9988篇 |
2006年 | 9573篇 |
2005年 | 9625篇 |
2004年 | 9080篇 |
2003年 | 8531篇 |
2002年 | 8278篇 |
2001年 | 1811篇 |
2000年 | 1454篇 |
1999年 | 1764篇 |
1998年 | 1831篇 |
1997年 | 1511篇 |
1996年 | 1397篇 |
1995年 | 1333篇 |
1994年 | 1167篇 |
1993年 | 1106篇 |
1992年 | 1034篇 |
1991年 | 1036篇 |
1990年 | 898篇 |
1989年 | 869篇 |
1988年 | 907篇 |
1987年 | 851篇 |
1986年 | 887篇 |
1985年 | 955篇 |
1984年 | 1008篇 |
1983年 | 932篇 |
1982年 | 1184篇 |
1981年 | 1221篇 |
1980年 | 1008篇 |
1979年 | 727篇 |
1978年 | 720篇 |
1977年 | 649篇 |
1976年 | 564篇 |
1975年 | 514篇 |
1974年 | 526篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
141.
James R. Trudell Wei-Qi Lin Dale A. Chrystof Gary Kirshenbaum C. Murray Ardies 《Alcoholism, clinical and experimental research》1995,19(3):753-758
Ethanol-induced fatty liver in rats was attenuated by repeated running exercise, and the protective effect of exercise was associated with the synergistic expression of heat shock proteins (HSP72). Rats were placed in four groups of six. The two ethanol-fed groups of rats received a liquid diet (Lieber-DeCarli formulation) in which 36% of the calories were derived from ethanol. One group remained sedentary (S/E), whereas the other was trained to run on a rodent treadmill at a speed of 27 m/min, 1 hr/day, 5 days/week, for 7 weeks (R/E). Two other groups–one exercised as previously mentioned (R/C) and one sedentary (S/C)–received control-liquid diets in which the ethanol was isocalorically substituted with a dextran/maltose mixture. The degree of fatty infiltration in liver sections stained with hematoxylin and eosin was graded on a 0–4 scale and the data analyzed by ANOVA on ranks. Ethanol significantly induced fatty infiltration in the S/E group, whereas fatty infiltration in the livers of the R/E group was not different from the S/C group. Electrophoresis and Western blotting of liver homogenates demonstrated that HSP72 was not expressed in either the S/C or S/E groups and was only slightly expressed in the R/C group. The combination of exercise and ethanol, however, resulted in an elevated expression of HSP72 in the R/E group. The content of HSP73 was unaffected by any treatment. 相似文献
142.
143.
Alpha2-HS glycoprotein phenotypes and quantitative hormone and bone measures in postmenopausal women
June E. Eichner Christopher A. Friedrich Jane A. Cauley Mohammad I. Kamboh James P. Gutai Lewis H. Kuller Robert E. Ferrell 《Calcified tissue international》1990,47(6):345-349
Summary It has been suggested that inherited traits play a role in the development of osteoporosis by providing a background for the
modulation of gene expression. In this study, we examine the influence of the different alleles of alpha2-HS glycoprotein (AHSG), a protein of the bone matrix, on quantitative estrogens, estrone and estradiol, and bone measures,
bone area and density. Estrogens provide a protective effect against fractures in older women and were thus included in the
analyses. Isoelectric focusing of AHSG from sera followed by immunoblotting was used to type 163 white post-menopausal women
participating in a clinical trial of the effects of walking on bone loss. Plasma hormones were measured by a combination of
extraction, column chromatography, and radioimmunoassay; bone measures on the dominant radius were determined with computerized
tomography. Analysis of variance was done on estrogen and bone measures after controlling for the effects of age and body
mass index. The two major alleles of AHSG result in three phenotypes, designated AHSG 1-1, AHSG 2-1, and AHSG 2-2. The AHSG
1-1 homozygote showed a decreased concentration of estradiol, the AHSG 2-2 homozygote showed an increased concentration, and
the AHSG 2-1 heterozygote was intermediate (P=0.001). Estrone demonstrated a similar pattern in residual analysis although it did not reach statistical significance. 相似文献
144.
This article identifies common characteristics of educationally related programs that form a common basis for understanding and working with gifted programs. Special approaches and programs for educational enrichment as well as specific activities that have been successful are discussed. 相似文献
145.
James L. Levenson M.D. Harold J. Fallon M.D. 《The American journal of gastroenterology》1993,88(5):760-761
Interferon-α is the only approved and effective treatment for hepatitis C. Psychiatric side effects are common and have frequently required a decrease in dose or discontinuation of therapy. We here report a case of interferon-α-induced depression in a 40-yr-old man with hepatitis C successfully treated with the antidepressant fluoxetine, which allowed completion of interferon treatment. 相似文献
146.
Heterosexual men and homosexual men rated how arousing different sexual fantasies were and how often they had used these fantasies
over the previous year. Within each group, sensual and genital same-orientation fantasies were more arousing than either public-sex
or dominance-submissive fantasies, which in turn were more arousing than aggressive-sex fantasies. For both heterosexual and
homosexual men the extent to which a fantasy was arousing correlated with the person's experience of the activity depicted
in the fantasy. The frequency of use of a fantasy correlated positively with its arousal level but not always subtantially
so. The results are discussed in the context of the mediating role of fantasy in human sexual arousal. 相似文献
147.
148.
Janice F. Munro Debra Haire-Joshu Edwin B. Fisher H. James Wedner 《The Journal of asthma》1996,33(5):313-325
Low-income minority patients from East St. Louis, Illinois, a depressed midwestern urban city, who had visited acute care settings with asthma symptoms, participated in a focus group. Questions were constructed around the Health Belief Model to characterize participants' experiences in receiving asthma care, their confidence in long-term asthma self-management, barriers they perceived to managing their asthma, and recommendations they would make for improving asthma care in their community. Analysis of comments suggests an appreciable understanding of asthma triggers, limited coping behaviors for asthma symptoms, very limited practice of active asthma management, perception of the health care system as frequently insensitive to their needs or their knowledge of their own care, exchange of well-articulated information regarding how to deal with the system, and an apparent lack of awareness of any potential contribution of patient education or support system. 相似文献
149.
Dr. Caroline S. Zeind Pharm.D. Dr. Kerry O. Cleveland M.D. Dr. Madhavi Menon M.D. Dr. James R. Brown Pharm.D. Dr. David K. Solomon Pharm.D. 《Pharmacotherapy》1996,16(4):547-561
The optimum therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS) remains unresolved. Traditional therapy consists of amphotericin B with or without flucytosine. Obstacles exist in administering these agents to patients with AIDS. Mortality rates during initial therapy are relatively high. Given the lack of proved benefit, we do not recommend adding flucytosine to amphotericin B routinely. The search for more efficacious and less toxic agents continues. The oral triazoles, especially fluconazole, have increased the options for treatment of this disease. New strategies and novel approaches in managing cryptococcal meningitis in patients with AIDS continue to be developed. 相似文献
150.
Three saxophone players with upper limb amputations have been successfully rehabilitated to play their musical instruments using skin-conductivity touch control. Each attained a standard of musicianship sufficient to perform the standard repertoire of the instrument in a concert setting. The mechanical and electrical modifications to the saxophone are described, as well as the principles of operation of the skin-conductivity touch control module. The touch control module is commercially available for prosthetists who wish to fit musicians or others with upper extremity amputations who require rapid accurate control of a number of channels of powered prosthetic function. 相似文献