2004-2005年新疆五县居民恶性肿廇死亡调查

恶性肿瘤是危害人民生命健康的重要疾病之一.为了解新疆居民恶性肿瘤死亡情况,为制定肿瘤防治对策提供依据,现对新疆5个疾病监测县2004-2005年居民恶性肿瘤死亡情况进行回顾性调查.     

2010年新疆监测点居民高血压现况分析

目的通过对新疆18岁及以上常住居民血压情况、高血压管理现状及其影响因素的调查,掌握高血压的知晓率、治疗率、血压控制率以及影响因素,为制定高血压干预措施提供依据。方法采用多阶段整群随机抽样的方法,调查了新疆5个监测点共2999名18岁及以上常住居民。采取集中和入户相结合调查的方式获得资料。采用SPSS 13.0统计分析软件进行分析。结果新疆监测点18岁及以上人群高血压患病率为33.34%,高血压知晓率为39.40%,高血压治疗率为31.20%,血压控制率为10.80%。Logistic单因素回归分析结果显示年龄大（OR=0.639,95%CI：0.598～0.682）、文化水平低（OR=1.165,95%CI：1.078～1.258）、汉族（OR=1.296,95%CI：1.167～1.439）、超重/肥胖（OR=0.506,95%CI：0.453～0.565）、食用水果不足（OR=1.286,95%CI：1.020～1.620）、食用蔬菜不足（OR=1.420,95%CI：1.183～1.705）、食用盐过量（OR=1.416,95%CI：1.120～1.790）、食用油过量（OR=1.532,95%CI：1.193～1.966）等患高血压的风险高。结论新疆监测点高血压患病率高,高血压知晓率、治疗率、血压控制率均低,高血压危害严重,高血压病人的治疗管理要加强;肥胖、吸烟、饮酒、蔬菜水果摄入不足、过量摄入食用油盐、低水平的身体活动等高血压危险因素居高不下,需要采取综合性干预措施和健康管理来逐步降低高血压病的危害。     

The protective effect of cuminaldehyde on gastric mucosa in Rattus norregicus of experimental gastric ulcer北大核心CSCD

Aim To explore the effect of cuminaldehyde in cumin fruit on gastric ulcer and the protective mechanism via establishing the gastric ulcer model of rats was by ethanol injury. Methods Thirty-six male R. norregicus were divided into six groups: control group, model group, omeprazole positive control group and cuminaldehyde low, medium and high dosage groups. After seven days of continuous intragastric administration, the acute gastric ulcer of R. norregicus was tested by absolute alcohol. Gastric ulcer area, inhibition rate, gastric tissue antioxidant activity, serum inflammatory factors and gastric mucosal protective factors were detected in different groups. Results The results showed that cuminaldehyde significantly reduced the area of gastric ulcer and increased the inhibition rate of gastric ulcer. The inhibition rate of cuminaldehyde at high dose group was up to 74.65%, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH) in gastric tissue significantly increased, and the contents of serum prolandin E2(PGE2) and NO in gastric tissue also significantly increased. The content of malondialdehyde (MDA) decreased. Compared with the model group, cuminaldehyde decreased the content of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in rat serum, and decreased the activity of myeloperoxidase (MPO). Conclusions Cuminaldehyde has good antioxidant stress ability and anti-inflammatory activity, increases the expression of protective factors, enhances the defense ability of gastric mucosa, and has obvious protective effect on acute gastric ulcer in R. norregicus. © 2023 Publication Centre of Anhui Medical University. All rights reserved.