心电图运动试验对判断经皮冠状动脉腔内成形术后再狭窄的…

对有重复冠脉造影和心电图运动试验复查的４１例经皮腔内冠状动脉成形（ＰＴＣＡ）术后患者进行回顾性分析，探讨心电图运动试验对判断再狭窄的意义。结果显示：ＰＴＣＡ术后无再狭窄组患者心电图运动试验各参数比术前明显改善，比再狭窄组亦有明显改善；运动试验阳性对ＰＴＣＡ术后再狭窄预测的敏感性为７９．２％，特异性为５８．８％，阳性预测值为７２．４％；４１例患者ＰＴＣＡ术后临床心绞痛症状的发生率为７５．６％（其中再     

r—干扰素对过度增生的血管平滑肌细胞癌基因表达的抑制作用

本实验建立了兔腹主动脉球囊扩张（ＢＡ）动物模型。以地高辛标记的ｃ－ｆｏｓ，ｃ－ｍｙｃ，Ｎ－ｒａｓ癌基因探针进行ＢＡ术后血管段组织的原位杂交，以生物素标记的ｃ－ｆｏｓ，ｃ－ｍｙｃ，Ｎ－ｒａｓ探针以经ＢＡ组织培养液刺激的、培养的血管平滑肌细胞（ＳＭＣ）进行细胞的原位杂交。结果显示：（１）ＢＡ术后再狭窄的血管段中ｃ－ｆｏｓ，ｃ－ｍｙｃ－Ｎ－ｒａｓ三种癌基因表达均增高，而且表达颗粒主要分布于粥样斑块再狭窄     

~(201)T1运动一再分布心肌平面显像对心肌缺血诊断和疗效观察的价值

本文报导了21例正常对照、19例心肌缺血患者~(201)Tl运动一再分布心肌平面显像的特点,讨论了心肌正常变异及影响心肌显像的因素。40例受试者同时作了冠状动脉造影、~(201)Tl心肌显像及运动ECG。以冠状动脉狭窄≥50％作为诊断冠心病的标准,~(201)Tl心肌显像的灵     

Percutaneous transluminal coronary angioplasty. Its success rate and affecting factors.

From December 1987 to October 1983, percutaneous transluminal coronary angioplasty (PTCA) was performed in 302 patients with 392 diseased vessels and 440 lesions. The success rate was 93.71% in 302 patients, 94.90% in 392 diseased vessels and 95.00% in 440 lesions. The success rate was 98.92% in Type A lesion, 95.71% in Type B lesion, and 86.57％ in Type C lesion (A vs B P=NS, A vs C P<0.01). There were 55 lesions with total or subtotal occlusion, the success rate was 89.09% (93.10% in Type B lesion and 84.62% in Type C lesion). As to the diseased vessels, the success rate was 95.65% in LAD, 94.38% in LCX and 93.75% in RCA. The results showed no significant difference. In this series,acute ischemic complications were found in 6.59% (29/440). Of these 29 lesions, 23 were treated successfully, 5 developed Q wave myocardial infarction and 1 died.     

心室晚电位检测在室性心律失常和心肌梗塞病人中的临床意义

对102例室性心律失常(VAs)伴或不伴心肌梗塞(MI)病人采用信号叠加心电图进行体表心室晚电位(LPs)检测发现,非AMI伴VAs病人LPs的检出(10/62,16.13%)与MI病人(14/40,35%)有显著差异(P<0.05);MI伴室性心动过速(VT)病例的LPs阳性率(8/12,66.67%)与MI不伴VAs病例(6/28,21.43%)及非MI伴VAs病例(10/62,16.13%)有显著差异(P<0.01);后二者间差异不显著(P>0.05)。这提示LPs出现与心肌异常折返活动有关,其最适检测对象是MI伴VT的高危人群。     

反义N—ras1基因对血管损伤后平滑肌细胞增殖的影响

为了防止血管损伤后狭窄或球囊成形术后再狭窄，观察反义Ｎ－ｒａｓ１基因对血管损伤后血管平滑肌细胞（ＶＳＭＣ）增殖的影响。方法实验动物随机分为基因治疗组、空载体对照及正义Ｎｒａｓ１重组质粒对照组。将实验血管进行血管造影、病理形态学检测、提取血管组织ｍＲＮＡ与Ｎ－ｒａｓ１探针进行Ｎｏｒｔｈｅｒｎ印迹杂交，应用Ｗｅｓｔｅｒｎ技术检测ｒａｓ癌基因族表达产物ｐ２１蛋白。结果血管造影显示，基因治疗组（治疗后４周）血管直径０．８０±０．１０（ｍｍ）；空载体对照组０．３５±０．１３（ｍｍ），两组差异有非常显著意义（Ｐ＜０．０１）；组织学检查显示治疗组新生内膜面积（治疗后４周）０．４３±０．０５ｍｍ２，空载体对照组０．８２±０．０３ｍｍ２，两组差异有非常显著意义（Ｐ＜０．０１）。治疗组血管ｒａｓｍＲＮＡ表达明显减少，且表达蛋白ｐ２１也明显受到抑制。结论反义Ｎ－ｒａｓ１基因对球囊损伤后ＶＳＭＣ增殖有明显抑制作用