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Mannheimia haemolytica induced pneumonias are only observed in goats, sheep and cattle. The bacterium produces several virulence factors,whose principal ones are lipopolysaccharide and leukotoxin. The latter is cytotoxic only for ruminant leukocytes, a phenomenon that is correlated with its ability to bind and interact with the ruminant beta2-integrin Lymphocyte Function-associated Antigen 1. This paper globally reviews all the information available on host-pathogen interactions underlying respiratory mannheimiosis (formerly pasteurellosis), from the stable and the Petri dish to the biochemical cascade of events triggered by the leukotoxin inside ruminant leukocytes. One conclusion can be made: the most widespread cattle respiratory disease with the most important impact on beef production worldwide, is probably due to a tiny ruminant-specific focal variation in the CD18- and/or CD11a-expressing genes. 相似文献
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Schulz Mayara Seraglio Siluana Katia Tischer Della Betta Fabiana Nehring Priscila Valese Andressa Camargo Daguer Heitor Gonzaga Luciano Valdemiro Costa Ana Carolina Oliveira Fett Roseane 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(1):110-115
Plant Foods for Human Nutrition - Yellow guava (Psidium cattleianum Sabine) has received considerable attention in the last years because of their high content in bioactive compounds with potential... 相似文献