排序方式: 共有180条查询结果,搜索用时 430 毫秒
131.
Perception of Curability Among Advanced Cancer Patients: An International Collaborative Study
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Sriram Yennurajalingam Luis Fernando Rodrigues Omar Shamieh Colombe Tricou Marilène Filbet Kyaw Naing Akhileshwaran Ramaswamy Pedro Emilio Perez‐Cruz Mary Jocelyn S. Bautista Sofia Bunge Mary Ann Muckaden Vikash Sewram Sarah Fakrooden Antonio Noguera‐Tejedor Shobha S. Rao Diane Liu Minjeong Park Janet L. Williams Zhanni Lu Hilda Cantu David Hui Suresh K. Reddy Eduardo Bruera 《The oncologist》2018,23(4):501-506
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Carli D. Needle BA Vignesh Ramachandran MD Vikash S. Oza MD 《Pediatric dermatology》2024,41(1):164-165
Across the world, there are varied cultural practices applied in the newborn period that pediatric dermatologists need to be familiar with. This report details a 9-day-old girl who presented with black, spike-like hairs across the back after her mother had been rubbing breast milk on her back in a circular motion for the first 7 days of life. On dermatoscopic exam, these lesions were found to be tight bundles of lanugo hairs, consistent with a diagnosis of knotted lanugo. Improved understanding of cultural practices and newborn skin care routines is critical for diagnosis, treatment, and counseling. 相似文献
135.
Madeline M. Pollifrone Kenda Cunningham Pooja Pandey Rana Morgan M. Philbin Shraddha Manandhar Krishna P. Lamsal Raj Nandan Mandal Vikash Deuja 《Maternal & child nutrition》2020,16(4)
Growth monitoring and promotion (GMP) is both a service for diagnosing inadequate child growth in its earliest stages and a delivery platform for nutrition counselling. The widespread use of GMP services in developing countries has the potential to substantially reduce persistent child undernutrition through early diagnosis and by linking caregivers and their children to key health and nutrition services. However, researchers have questioned the effectiveness of GMP services, which are frequently undermined by underdeveloped health systems and inconsistent implementation. This analysis examined both supply‐ and demand‐side factors for GMP utility in Nepal from the perspectives of beneficiaries and service providers, particularly focusing on three components of GMP: growth assessment, analysis of growth status and counselling. The most common factors influencing GMP uptake included beneficiaries' perceptions of the relative importance of GMP and the knowledge and skill of frontline workers. Both providers and beneficiaries viewed GMP as a secondary health and nutrition activity and therefore less important than curative services. We found deficits in GMP‐related knowledge and skills among providers (i.e. health workers and female community health volunteers), as well as indications of poor training quality and coverage. Furthermore, we found variation in GMP utilization by maternal age, education and residency (alone, nuclear or extended), as well as household socio‐economic well‐being and rurality. This study is the first to assess factors influencing both beneficiaries and service providers for GMP utilization. Further research is needed to explore the implementation of improved GMP protocols and to evaluate facility‐level implementation barriers. 相似文献
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Trevor K. Young BS Daniel Gutierrez MD Shane A. Meehan MD Rebecca Pellett Madan MD Vikash S. Oza MD 《Pediatric dermatology》2020,37(3):531-533
Infectious panniculitis from hematogenous spread is uncommon and usually occurs in immunocompromised patients. Dissemination of gram-positive organisms to the subcutaneous tissue is rare with only several reports of disseminated panniculitis caused by Streptococcal species. We report a case of an immunocompetent 2-year-old boy presenting with diffuse neutrophilic panniculitis arising from methicillin-resistant Staphylococcus aureus septicemia. This case represents a highly atypical manifestation of severe MRSA infection and serves as a reminder to consider MRSA as a cause of disseminated neutrophilic panniculitis, particularly in high-risk populations. 相似文献
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Prakash Saudagar Vikash Kumar Dubey 《The American journal of tropical medicine and hygiene》2014,90(2):354-360
Although leishmanial infections of humans occur globally, the major health impact lies in developing nations, thus, leishmaniases remain “neglected” diseases for new drugs development. Multidrug resistance has been documented in most countries where leishmaniases is endemic. Betulin is a widely available and affordable natural product exerting leishmanicidal activity at micromolar concentration. In this study, the molecular mechanisms of death that contribute to the anti-leishmanial activity of betulin are investigated. In promastigotes, betulin stimulated reactive oxygen species generation at micromolar concentrations in Leishmania. Apoptosis was observed in betulin-treated promastigotes using flow cytometric analysis of treated cells stained with annexin V-FITC and propidium iodide. Furthermore, betulin treatment of promastigotes led to mitochondrial membrane damage, activation of caspase-like proteases, and DNA fragmentation in Leishmania donovani promastigotes. Betulin treatment of amastigotes cultured within macrophages, resulted in a reduced number of amastigotes, with no substantive cytotoxic damage to the host macrophage cells at leishmanicidal drug concentrations. 相似文献
138.
Eosinophilic Pustular Folliculitis in Children after Stem Cell Transplantation: An Eruption Distinct from Graft‐Versus‐Host Disease
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Martin Theiler M.D. Vikash S. Oza M.D. Erin F. Mathes M.D. Christopher C. Dvorak M.D. Timothy H. McCalmont M.D. Iwei Yeh M.D Ph.D. Robert Sidbury M.D. M.P.H. Kelly M. Cordoro M.D. 《Pediatric dermatology》2017,34(3):326-330
Eosinophilic pustular folliculitis (EPF) is a rare cutaneous disorder that typically occurs in three clinical contexts: men, individuals who are immunosuppressed or have human immunodeficiency virus, and infants. A fourth subtype occurring 2 to 3 months after hematopoietic stem cell transplantation (HSCT) has recently been described in several adults. We report two cases of EPF arising in children after HSCT. It is important to recognize this form of EPF after HSCT and differentiate it from graft‐versus‐host disease since it responds readily to topical steroids and appears to have an excellent prognosis. 相似文献
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Thomas Stringer BA Elizabeth Ghazi MD Gilberto Alvarez del Manzano MD Jenna Beasley MD Nooshin Brinster MD Vikash S. Oza MD 《Pediatric dermatology》2017,34(6):e347-e348
Ticks are a well‐known vector for viral, bacterial, and rickettsial infections, many of which are accompanied by cutaneous eruptions, but the bite itself can induce a spectrum of inflammatory reactions, including foreign body granuloma, tick bite alopecia, and cutaneous lymphoid hyperplasia. We describe the development of an indeterminate cell histiocytic infiltrate at the site of a tick bite. Although the etiology of intermediate cell histiocytosis is not well understood, this case raises the possibility that such infiltrates may represent an inflammatory reaction in some patients. 相似文献
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Mousumi Das Gundappa Saha Anil K. Saikia Vikash Kumar Dubey 《Antimicrobial agents and chemotherapy》2015,59(12):7826-7829
Visceral leishmaniasis is a deadly endemic disease. Unresponsiveness to the only available oral drug miltefosine poses a big challenge for the chemotherapy of the disease. We report a novel molecule, PS-203 {4-(4,4,8-trimethyl-7-oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester}, as effective against a miltefosine-unresponsive strain of the parasite. Further, combinations of PS-203 with miltefosine were also evaluated and showed promising results against a miltefosine-unresponsive strain. 相似文献