口腔颌面部恶性肿瘤手术前后血清TRF、RBP和PAB变化及临床意义

目的探讨血清中营养状态监测指标转铁蛋白（TRF）、视黄醇结合蛋白（RBP）、前清蛋白（PAB）在口腔颌面部恶性肿瘤手术前后的变化及临床意义。方法采用免疫散射比浊法,检测30例口腔颌面部恶性肿瘤病人术前3d、术后1周、术后1个月血清中TRF、RBP、PAB水平,以30例良性肿瘤病人作为对照组,以30例健康人作为空白对照组。结果口腔颌面部恶性肿瘤病人术前TRF、RBP、PAB水平与对照组及空白对照组相比,差异无统计学意义（P〉o．05）。口腔颌面部恶性肿瘤病人术后1周血清TRF、RBP、PAB水平与术前相比,差异有统计学意义（t=3．37～5．88,P％0．01）;术后1个月与术前相比,差异无统计学意义（P〉0．05）。结论TRF、RBP、PAB的检测可为口腔颌面部恶性肿瘤术后营养状况提供可靠依据,有一定的临床应用价值。     

宫术宁胶棒在绝经后妇女取环术中的应用

目的 观察绝经后妇女取环术中应用宫术宁胶棒(宫颈扩张棒)的临床效果.方法 选择来我所要求取环的绝经妇女共260例.随机分为两组:观察组130例,为宫术宁胶棒联合尼尔雌醇;对照组130例,为尼尔雌醇配伍米索前列醇.观察两组术中宫颈软化扩张情况、镇痛效果、综合反应程度、取器效果.结果 观察组宫颈软化、扩张、镇痛、综合反应与...     

Influence of the Oral Administration of Excess Copper on the Immune Response

We have studied the influence of the oral administration ofexcess copper (Cu) on the immune response. With this aim, micemaintained on standard laboratory diet received 50, 100, 200,or 300 ppm of Cu as copper sulfate in the drinking water during3 to 10 weeks. Inhibition of the proliferative response to concanavalinA was observed in mice exposed to 100 ppm of Cu for 8 weeksand to 200 ppm of Cu for either 3 or 8 weeks. Conversely, asignificant increase in the proliferative response to Eschenchiacolilipopolysaccharide (LPS) was observed in mice exposed to50 or 100 ppm of Cu for 3 weeks. However, the response to LPSwas also significantly inhibited following prolonged Cu administration.In contrast, mice exposed to low or high Cu doses during shortor long periods showed increased production of autoantibodiesdirected to bromelain-treated mouse erythrocytes. The DTH responseto sheep red blood cells was not modified following short-termadministration of 100 ppm of Cu, but was depressed after prolongedexposure to this dose of the metal. Significant inhibition ofthe DTH response was observed in mice exposed to 300 ppm ofCu for 5 or 10 weeks. Thus, oral administration of excess Cualtered the immune response in a fashion related to the doseand duration of treatment     

Adenovirus-mediated Transfer of p53 and p16Inhibiting Proliferating Activity of Human Bladder Cancer Cell EJin vitro and in vivo

Previous studies have shown the tumor sup-pressor genes p5 3and p1 6were mutated or defect-ed in70 % and73% of the transurethral resectionbladder tumor( TURBt) specimens respectively[1] .The aim of this study was to evaluate the effects ofadenovirus ( Ad) - mediated transfer of p5 3and p1 6on the proliferating activity of human bladder can-cer cells EJboth in vitro and in vivo.1　 MATERIAL SAND METHODS1 .1　 Cell Lines and Adenoviral VectorsThe human bladder cancer cell line EJwas …     

Randomised controlled trial of growth effect of hydrocortisone in congenital adrenal hyperplasia

The influence of 15 or 25 mg/m2 of daily oral hydrocortisone with fludrocortisone 0.1 mg/day on growth and laboratory findings was evaluated in a prospective randomised crossover trial over 12 months in 26 children with 21-hydroxylase deficiency. Nine non-salt losers had fludrocortisone stopped for a further six month period. Height velocity was significantly decreased during treatment with 25 mg/m2 as compared with 15 mg/m2. This was the most sensitive indicator of corticosteroid treatment excess. A dose dependent effect upon plasma concentrations of 17-hydroxyprogesterone, testosterone, and androstenedione was found but increased values were still detected in more than half of the determinations made during the 25 mg/m2 period. Height velocity and 17-hydroxyprogesterone concentrations were positively correlated. Growth hormone response to clonidine stimulation and insulin-like growth factor-1 concentrations were both within reference values and there was no difference between treatment periods. Withdrawal of fludrocortisone did not result in any difference for the non-salt losers. It was concluded that 25 mg/m2 of hydrocortisone depressed growth in children with congenital adrenal hyperplasia, and that full suppression, or even normalisation, of plasma concentrations of 17-hydroxyprogesterone and androgens should not be considered a treatment goal, but instead an indication of corticosteroid treatment excess.     

The effects of long-term anticonvulsive treatment on serum lipid profile

Serum lipids were determined in 10 untreated patients with recently diagnosed epilepsy, 21 patients treated with carbamazepine (CBZ), 10 patients treated with valproate (VPA) and in 15 healthy children. In relation to the controls, patients receiving CBZ showed increased serum high-density lipoprotein cholesterol (HDLc), apolipoprotein A (Apo-A) and apolipoprotein B (Apo-B). Patients receiving VPA showed increased Apo-B levels. There were no significant differences in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDLc) or very low-density lipoprotein cholesterol (VLDLc) between all groups. The changes in lipid metabolism may be associated with the induction of liver enzymes during anti-epileptic drug metabolism. The CBZ-induced change in serum lipid levels was considered to be a possible factor against atherosclerosis and coronary heart disease in epileptic patients.