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991.
Christian A. Di Buduo Alicia Aguilar Paolo M. Soprano Alberto Bocconi Carolina P. Miguel Giovanna Mantica Alessandra Balduini 《Haematologica》2021,106(4):947
Since the dawn of medicine, scientists have carefully observed, modeled and interpreted the human body to improve healthcare. At the beginning there were drawings and paintings, now there is three-dimensional modeling. Moving from two-dimensional cultures and towards complex and relevant biomaterials, tissue-engineering approaches have been developed in order to create three-dimensional functional mimics of native organs. The bone marrow represents a challenging organ to reproduce because of its structure and composition that confer it unique biochemical and mechanical features to control hematopoiesis. Reproducing the human bone marrow niche is instrumental to answer the growing demand for human erythrocytes and platelets for fundamental studies and clinical applications in transfusion medicine. In this review, we discuss the latest culture techniques and technological approaches to obtain functional platelets and erythrocytes ex vivo. This is a rapidly evolving field that will define the future of targeted therapies for thrombocytopenia and anemia, but also a long-term promise for new approaches to the understanding and cure of hematologic diseases. 相似文献
992.
Aniket Bankar Thirushi Piyumika Siriwardena Biljana Rizoska Christina Rydergrd Helen Kylefjord Vilma Rraklli Anders Eneroth Pedro Pinho Stefan Norin Johan Bylund Sara Moses Richard Bethell Simon Kavanagh Neil Maclean Marcela Gronda Xiaoming Wang Rose Hurren Mark D. Minden Paul Targett-Adams Aaron D. Schimmer Mark Albertella 《Haematologica》2021,106(2):574
993.
Garcia-Silva Rafael Hernandez-Doño Susana Román-Amparo Jeniffer Patricia Trujillo-Vizuet Ma Guadalupe Mena-Vela Blanca Aurora Rizo-Pinto Andrea Tirado José Manuel Pérez Cetina-Díaz José Hiram Bulos-Rodríguez Pedro Granados Julio Sepúlveda-Delgado Jesús 《Clinical rheumatology》2021,40(8):3095-3103
Clinical Rheumatology - Systemic lupus erythematosus (SLE) is the prototypic autoimmune disease that disrupts numerous immunity mechanisms with the potential to exert damage to any organ or tissue.... 相似文献
994.
Norm R.C. Campbell Pedro Ordunez Gloria Giraldo Yenny A. Rodriguez Morales Cintia Lombardi Taskeen Khan Raj Padwal Ross T. Tsuyuki Cherian Varghese 《The Canadian journal of cardiology》2021,37(5):744-755
Globally, cardiovascular diseases (CVDs) are the leading cause of death. Viewed as a threat to the global economy, the United Nations included reducing noncommunicable diseases, including CVDs, in the 2030 sustainable development goals, and the World Health Assembly agreed to a target to reduce noncommunicable diseases 25% by the year 2025. In response, the World Health Organisation led the development of HEARTS, a technical package to guide governments in strengthening primary care to reduce CVDs. HEARTS recommends a public health and health system approach to introduce highly simplified interventions done systematically at a primary health care level and has a focus on hypertension as a clinical entry point. The HEARTS modules include healthy lifestyle counselling, evidence-based treatment protocols, access to essential medicines and technology, CVD risk-based management, team-based care, systems for monitoring, and an implementation guide. There are early positive global experiences in implementing HEARTS. Led by the Pan American Health Organisation, many national governments in the Americas are adopting HEARTS and have shown early success. Unfortunately, in Canada hypertension control is declining in women since 2010-2011 and the dramatic reductions in rates of CVD seen before 2010 have flattened when age adjusted and increased for rates that are not age adjusted, and there are marked increases in absolute numbers of Canadians with adverse CVD outcomes. Several steps that Canada could take to enhance hypertension control are outlined, the core of which is to implement a strong governmental nongovernmental collaborative strategy to prevent and control CVDs, focusing on HEARTS. 相似文献
995.
996.
Hernández-Díaz Yazmín González-Castro Thelma Beatriz Tovilla-Zárate Carlos Alfonso López-Narváez María Lilia Genis-Mendoza Alma Delia Castillo-Avila Rosa Giannina Ramos-Méndez Miguel Ángel Juárez-Rojop Isela Esther 《Metabolic brain disease》2021,36(8):2415-2424
Metabolic Brain Disease - Schizophrenia is a debilitating mental illness. Levels of oxytocin have been proposed as a biomarker of schizophrenia; however, the observed levels of oxytocin in... 相似文献
997.
Molina Collada Juan Macía-Villa Cristina Plasencia Chamaida Álvaro-Gracia José María de Miguel Eugenio 《Clinical rheumatology》2021,40(5):2013-2020
Clinical Rheumatology - To analyse the frequency of power Doppler (PD) enthesitis in active axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients and its potential usefulness in... 相似文献
998.
Sousa Pedro A. Barra Sérgio Puga Luís Sousa Catarina Elvas Luís 《Journal of interventional cardiac electrophysiology》2022,63(2):431-440
Journal of Interventional Cardiac Electrophysiology - The purpose of the study was to investigate the usefulness of the extended early meets late (EEML) feature of the HD Coloring software for... 相似文献
999.
Schmidt Cristine Moreira-Gonçalves Daniel Santos Mário Leite-Moreira Adelino Oliveira José 《Heart failure reviews》2022,27(2):573-586
Heart Failure Reviews - Conventional treatments for heart failure have failed to improve survival in heart failure with preserved ejection fraction (HFpEF). The current therapy recommendations... 相似文献
1000.