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51.
Savvateeva-Popova E Popov A Grossman A Nikitina E Medvedeva A Molotkov D Kamyshev N Pyatkov K Zatsepina O Schostak N Zelentsova E Pavlova G Panteleev D Riederer P Evgen'ev M 《Journal of neural transmission (Vienna, Austria : 1996)》2008,115(12):1629-1642
At most, many protein-misfolding diseases develop as environmentally induced sporadic disorders. Recent studies indicate that
the dynamic interplay between a wide repertoire of noncoding RNAs and the environment play an important role in brain development
and pathogenesis of brain disorders. To elucidate this new issue, novel animal models which reproduce the most prominent disease
manifestations are required. For this, transgenic Drosophila strains were constructed to express small highly structured, non-coding RNA under control of a heat shock promoter. Expression
of the RNA induced formation of intracellular aggregates revealed by Thioflafin T in embryonic cell culture and Congo Red
in the brain of transgenic flies. Also, this strongly perturbed the brain control of locomotion monitored by the parameters
of sound production and memory retention of young 5-day-old males. This novel model demonstrates that expression of non-coding
RNA alone is sufficient to trigger neuropathology. 相似文献
52.
The genes encoding effector molecules of mature T cells, IL-2, perforin and
IL-4, were found to be expressed in vivo in the most primitive subsets of
thymocytes of adult mice. These subsets have previously been identified by
their cell surface markers and by their expression of other T
lineage-associated genes. While IL-2, perforin and IL-4 are expressed in
distinct patterns, all three are expressed before the induction of RAG-1
and pre-TCR alpha mRNA expression, and are confined to subsets of cells
that apparently have not yet undergone commitment to the T lineage. Thus,
expression of T cell response genes appears to be one of the earliest
markers of lymphocyte differentiation. Activation events marked by CD69
induction occur in these early cell types, but the response gene expression
by these cells is separable from CD69 expression. IL-2 and perforin are
induced again much later in thymocyte development, during TCR-dependent
repertoire selection. At those stages, IL-2 protein and RNA levels per cell
are higher, but the fraction of cells expressing IL-2 appears to be much
lower than in the most immature stages. In addition, a striking feature of
the immature populations is the robust IL-2 expression by presumptive
immature NK cells. These findings are discussed in terms of the
developmental origins of lineage specificity in T cell response gene
regulation.
相似文献
53.
Devard I. Stom Tatyana A. Geel Alla E. Balayan Galina I. Shachova Aleksandr M. Kuznetsov Svetlana E. Medvedeva 《Archives of environmental contamination and toxicology》1992,22(2):203-208
The inhibition of bacterial luminescence has been used in testing industrial enterprises sewage. The toxicity of the sewage is less than the total toxicity of separate components due to neutralization of quinone products of polyphenol oxidation in the reactions with the other phenol components of sewage. Toxicity increase is due to their influence on the cell membrane. Studies of cell ultrastructure confirm this fact. The studied mechanism of the complex effect allowed a more accurate forecast of the ecological situation during the discharge of phenol compounds and metals. It also showed the necessity of taking into account the complex effect of sewage components on contaminant discharge into water reservoirs. 相似文献
54.
A. N. Evstropov V. E. Yavorovskaya E. S. Vorob'ev Z. P. Khudonogova L. N. Gritsenko E. V. Shmidt S. G. Medvedeva V. D. Filimonov T. P. Prishchep A. S. Saratikov 《Pharmaceutical Chemistry Journal》1992,26(5):426-430
Translated from Khimiko-farmatsevitcheskii Zhurnal, Vol. 26, No. 5, pp. 5–53, May, 1992. 相似文献
55.
56.
Medvedeva LA Gnezdilov AV Zagorul'ko OI Syrovegin AV Samoilova NV 《Neuroscience and behavioral physiology》2007,37(5):523-526
Studies were performed on 126 patients with chronic tension headache (CTH). Patients were divided into two groups — an experimental
group (64 patients) and a control group (62). Control patients received standard treatment (tizanidine, fluoxetine, vinpocetin,
and manual acupressure of active points in the trapezius muscles and the temporomastoid area of the head); the experimental
group also received Mexidol. Clinical and neurophysiological studies, including electromyography, were performed before and
after treatment. Comparison of the treatment outcomes in the two groups showed that inclusion of Mexidol into the complex
therapy of chronic CTH led to faster and more marked clinical effects.
__________
Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 106, No. 5, pp. 38–41, May, 2006. 相似文献
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