全文获取类型
收费全文 | 1203篇 |
免费 | 45篇 |
国内免费 | 2篇 |
学科分类
医药卫生 | 1250篇 |
出版年
2023年 | 6篇 |
2022年 | 12篇 |
2021年 | 36篇 |
2020年 | 12篇 |
2019年 | 19篇 |
2018年 | 18篇 |
2017年 | 28篇 |
2016年 | 18篇 |
2015年 | 34篇 |
2014年 | 37篇 |
2013年 | 42篇 |
2012年 | 73篇 |
2011年 | 70篇 |
2010年 | 37篇 |
2009年 | 77篇 |
2008年 | 81篇 |
2007年 | 79篇 |
2006年 | 71篇 |
2005年 | 63篇 |
2004年 | 54篇 |
2003年 | 47篇 |
2002年 | 34篇 |
2001年 | 42篇 |
2000年 | 32篇 |
1999年 | 26篇 |
1998年 | 14篇 |
1997年 | 13篇 |
1996年 | 14篇 |
1995年 | 10篇 |
1994年 | 13篇 |
1993年 | 5篇 |
1992年 | 15篇 |
1991年 | 10篇 |
1990年 | 10篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1980年 | 3篇 |
1979年 | 9篇 |
1978年 | 9篇 |
1977年 | 3篇 |
1975年 | 4篇 |
1974年 | 8篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 5篇 |
排序方式: 共有1250条查询结果,搜索用时 15 毫秒
91.
Activity-rest stimulation protocol improves cardiac assistance in dynamic cardiomyoplasty. 总被引:1,自引:0,他引:1
Gianluca Rigatelli Ugo Carraro Mario Barbiero Mario Zanchetta Konstantinos Dimopoulos Franco Cobelli Riccardo Riccardi Giorgio Rigatelli 《European journal of cardio-thoracic surgery》2002,21(3):478-482
OBJECTIVE: No data have ever been published regarding cardiac assistance in demand dynamic cardiomyoplasty (DDCMP). We tested the efficacy of the Doppler flow wire in measuring beat-to-beat aortic flow velocity and evaluating cardiac assistance in demand cardiomyoplasty patients. METHODS: The technique was tested in seven patients (M/F=6/1; age=57.1+/-6.2 years; atrial fibrillation/sinus rhythm=1/6; NYHA=1.4+/-0.5). Measurements were done using a 0.018inch peripheral Doppler flow wire advanced through a 5F arterial femoral sheath. Three 1-min periods with the stimulator off and three 1-min periods with clinical stimulation were recorded. We measured peak aortic flow velocity in all beats. Latissimus dorsi (LD) mechanogram was simultaneously recorded. RESULTS: Comparison between pre-operative and follow-up data showed significantly higher values of tetanic fusion frequency (TFF) and ejection fraction at follow-up, whereas mean NYHA class was significantly lower. Statistical analysis showed an increase in aortic flow velocity not only in assisted versus rest period, but also in assisted versus unassisted beats (8.42+/-6.98% and 7.55+/-3.07%). A linear correlation was found between the increase in flow velocity and LD wrap TFF (r(2)=0.53). CONCLUSIONS: In DDCMP, systolic assistance is significant and correlated to LD speed of contraction; demand stimulation protocol maintains muscle properties and increases muscle performance. 相似文献
92.
VG Hamburg 《MedR Medizinrecht》2009,27(8):485-487
Zusammenfassung Die Anerkennung einer Fortbildungsveranstaltung setzt voraus, dass sie dazu dient, die zur ?rztlichen
Berufsausübung erforderlichen Fachkenntnisse in der vertrags?rztlichen Versorgung zu erwerben
oder auszubauen. Veranstaltungen, die ausschlie?lich als Instrument zur Verbesserung der Wettbewerbsf?higkeit
eines niedergelassenen Arztes dienen, sind nicht als Fortbildungsma?nahmen anerkennungsf?hig.
(Leitsatz der Bearbeiterin) 相似文献
93.
Evangelos Terpos Anna Tasidou Efstathios Kastritis Evangelos Eleftherakis-Papaiakovou Maria Gavriatopoulou Magdalini Migkou Meletios-Athanassios Dimopoulos 《Clinical lymphoma & myeloma》2009,9(1):46-49
Angiogenesis represents an essential step of disease progression in several hematological malignancies. In Waldenström's macroglobulinemia (WM) the bone marrow microvessel density is increased in 30%–40% of patients but seems to have no impact on survival. Angiogenic cytokines, such as angiogenin, vascular endothelial growth factor, and basic fibroblast growth factor are increased in the serum of WM or IgM-MGUS patients, while the ratio of angiopoietin-1/angiopoietin-2 is reduced in WM but not in IgM—monoclonal gammopathy of undetermined significance (MGUS). Angiogenin and angiopoietin-1/angiopoietin-2 ratio correlates with disease activity and clinical features of WM. Macrophage and mast-cell chemoattractants, such as macrophage inflammatory protein-1 alpha are also elevated in the serum of patients with WM, while both macrophages and mast cells that are increased in the WM microenvironment have angiogenic properties and participate in the angiogenesis process in several malignancies. This review summarizes all data available by November 2008 (end of literature search) for the role of angiogenesis in the biology of WM and its correlation with clinical and laboratory features of the disease. 相似文献
94.
VG Osnabrück 《MedR Medizinrecht》2000,18(10):488-492
Ohne Zusammenfassung 相似文献
95.
96.
P. Montravers S. Blot G. Dimopoulos C. Eckmann P. Eggimann X. Guirao J. A. Paiva G. Sganga J. De Waele 《Intensive care medicine》2016,42(8):1234-1247
Purpose
The management of peritonitis in critically ill patients is becoming increasingly complex due to their changing characteristics and the growing prevalence of multidrug-resistant (MDR) bacteria.Methods
A multidisciplinary panel summarizes the latest advances in the therapeutic management of these critically ill patients.Results
Appendicitis, cholecystitis and bowel perforation represent the majority of all community-acquired infections, while most cases of healthcare-associated infections occur following suture leaks and/or bowel perforation. The micro-organisms involved include a spectrum of Gram-positive and Gram-negative bacteria, as well as anaerobes and fungi. Healthcare-associated infections are associated with an increased likelihood of MDR pathogens. The key elements for success are early and optimal source control and adequate surgery and appropriate antibiotic therapy. Drainage, debridement, abdominal cleansing, irrigation, and control of the source of contamination are the major steps to ensure source control. In life-threatening situations, a "damage control" approach is the safest way to gain time and achieve stability. The initial empirical antiinfective therapy should be prescribed rapidly and must target all of the micro-organisms likely to be involved, including MDR bacteria and fungi, on the basis of the suspected risk factors. Dosage adjustment needs to be based on pharmacokinetic parameters. Supportive care includes pain management, optimization of ventilation, haemodynamic and fluid monitoring, improvement of renal function, nutrition and anticoagulation.Conclusions
The majority of patients with peritonitis develop complications, including worsening of pre-existing organ dysfunction, surgical complications and healthcare-associated infections. The probability of postoperative complications must be taken into account in the decision-making process prior to surgery.97.
98.
Papadimitriou CA Dimopoulos MA Kouvelis V Kostis E Kapsimali V Contoyannis D Anagnostopoulos A Papadimitris C Kiamouris C Gika D Nanas J Athanassiades P Stamatelopoulos S 《Journal of clinical apheresis》2000,15(4):236-241
High-dose chemotherapy with autologous peripheral blood progenitor cell (PBPC) support has become a widely used treatment strategy. In order to simplify the procedure, a single very large-volume leukapheresis programme combined with short-term refrigerated storage of the PBPC was developed. Seventy-two patients suffering from various relatively chemosensitive malignancies received high-dose chemotherapy, consisting of agents with short in vivo half-lives and 24 to 48 hours later, the refrigerated PBPC were reinfused. A single very large-volume apheresis was sufficient to obtain at least 2 x 10(6)/kg CD34+ cells in 58 patients (81%), and 63% had at least 2.5 x 10(6) CD34+ cells/kg. Only two patients (3%) were transplanted with less than 1 x 10(6) CD34+ cells/kg. In three patients (4%) leukapheresis was repeated because of insufficient number of PBPC. The median CD34+ cell count was 3 x 10(6)/kg. A median of 38.5 L blood (range, 21 to 59) was processed, which accounted for a median of 9 x patient's total blood volume. Very large-volume leukapharesis was well tolerated with symptomatic hypocalcemia being the most common (18%) side-effect. The median time to neutrophils >1.5 x 10(9)/L, and to self-supporting platelet count >25 x 10(9)/L, was 10 and 12 days after reinfusion of PBPC graft, respectively. There were no treatment-related deaths. Our results indicate that this simplified approach of PBPC transplantation can be associated with prompt hematologic recovery in most patients and that it can be useful in settings where facilities are limited or for certain diseases where conditioning regimens with short half-life are appropriate. J. Clin. Apheresis, 15:236-241, 2000. 相似文献
99.
Ioannis Siasios Konstantinos Fountas Vassilios Dimopoulos John Pollina 《Neurosurgical review》2018,41(1):47-53
Dysphagia is a common postoperative symptom for patients undergoing anterior cervical spine procedures. The purpose of this study is to present the current literature regarding the effect of steroid administration in dysphagia after anterior cervical spine procedures. We performed a literature search in the PubMed database, using the following terms: “dysphagia,” “ACDF,” “cervical,” “surgery,” “anterior,” “spine,” “steroids,” “treatment,” and “complications.” We included in our review any study correlating postoperative dysphagia and steroid administration in anterior cervical spine surgery. Studies, which did not evaluate, pre- and postoperatively, dysphagia with a specific clinical or laboratory methodology were excluded from our literature review. Five studies were included in our results. All were randomized, prospective studies, with one being double blinded. Steroid administration protocol was different in every study. In two studies, dexamethasone was used. Methylprednisolone was administrated in three studies. In four studies, steroids were applied intravenously, while in one study, locally in the retropharyngeal space. Short-term dysphagia and prevertebral soft tissue edema were diminished by steroid administration, according to the results of two studies. In one study, prevertebral soft tissue edema was not affected by the steroid usage. Furthermore, short-term osseous fusion rate was impaired by the steroid administration, according to the findings of one study. The usage of steroids in patients undergoing anterior cervical spine procedures remains controversial. Multicenter, large-scale, randomized, prospective studies applying the same protocol of steroid administration and universal outcome criteria should be performed for extracting statistically powerful and clinically meaningful results. 相似文献
100.
WH Belloso LC Orellana B Grinsztejn JS Madero A La Rosa VG Veloso J Sanchez R Ismerio Moreira B Crabtree‐Ramirez O Garcia Messina MB Lasala J Peinado MH Losso 《HIV medicine》2010,11(9):554-564