折光率快速测定碘海醇注射液含量的方法研究

摘 要 目的：建立折光率与碘海醇注射液的化学计量关系。方法: 采用Rudolph J257与Mettler Toledo RE40D折光仪对多企业生产的碘海醇注射液进行测定,将折光率与电位滴定法测得的含量结果建立化学计量关系式C=2.828R-3.769。结果:对76批次样品的电位滴定测得的含量结果与经折光率计算得到的模拟结果进行比较,模拟结果与实测结果的相对偏差小于2%,辅料不干扰测定。结论:本法简便、快速、准确,可用于碘海醇产品的过程控制及市场监督。     

乳腺癌改良术后“Y”型管引流的护理体会

我院1997－06~1998－08实施乳腺癌改良根治术,术后腋下及胸骨分均放置"Y"型乳胶管引流,使引流更充分,效果更好,现报道如下。1临床资料本组资料实施乳腺癌改良根治术66例,均为女性,年龄28～68岁．2术后引流方法将本组资料随机分2组,实验组36例,为腋下及胸骨旁放置"Y"型乳胶管引流,引流管直径0．6~0．8cm,接负压为2．67kPa,容量为1000ml的负压引流瓶吸引引流,术区加压包扎,对照组30例,常规采用单纯腋下放置乳胶管引流．3护理观察乳腺癌改良根治术,手术创面大,渗血渗液难以避免,眼窝及锁骨下区有较大间隙,术后放．置引流管…     

海络因成瘾对下丘脑神经内分泌激素系统的影响

为探索海洛因依赖对人体下丘脑神经内分泌系统影响,本实验应用放射免疫法,检测了７０名海洛因依赖者脱瘤治疗前二三轴变化即下丘脑－垂体－肾上腺轴（ＰＡ）、下丘脑０垂体０甲状腺轴（ＨＰＴ）、下丘脑－垂体性腺轴（ＨＰＡＡ）共１２ 种内分泌激素水平的变化,并与６２例健康者作对照。结果显示,ＨＰＡ活性增强,ＨＰＴ、ＨＰＡＡ激素水平下降,其原因是与阿片类毒吕抑制海洛因依赖者内生阿片类物质生成和下丘脑神经元兴奋,导     

电视腹腔镜在多囊卵巢中的应用

多囊卵巢(ＰＣＯ)是引起月经不调和不孕的常见原因,以往采用卵巢楔形切除治疗,随后用促排卵药物治疗,但部分患者治疗无效,本文对此类患者进行电视腹腔镜诊治,报道如下资料与方法　1977年1月～1999年4月在云南省第一人民医院就诊的多囊卵巢患者28例,术前曾给予促排卵药物克罗米酚、ＦＳＨ加大剂量仍无效患者,年龄25～35岁,平均289岁,不孕年限4～13年,平均49年,其中原发不孕18例,继发不孕10例。诊断标准为具备以下条件中的2项以上者诊断为ＰＣＯ:①月经稀发、闭经、原发或继发不孕,可伴肥胖及多毛;②ＢＢＴ单项或Ｂ超见双侧卵巢均匀性增大或大…     

来昔决南钐[^153Sm]注射液的急性毒性试验

目的：研究来昔决南钐「＾１５３Ｓｍ」（＾１５３Ｓｍ－ＥＤＴＭＰ）注射液和配体来昔决南钐（ＥＤＴＭＰ）溶液对大鼠、小鼠单次注射后的急性毒性。方法：小鼠尾静脉注射对数剂量的ＥＤＴＭＰ溶液,测定ＬＤ５０;大鼠尾静脉注射４个剂量的＾１５３Ｓｍ－ＥＤＴＭＰ注射液,观察大鼠的急性毒性反应。结果：ＥＤＴＭＰ对小鼠尾静脉注射的ＬＤ５０为７．１ｍｇ／ｋｇ,＾１５３Ｓｍ－ＥＤＴＭＰ对大鼠的ＬＤ５０大于３７０ＭＢｑ／ｋｇ。结论：在指定的给药方式下,＾１５３Ｓｍ－ＥＤＴＭＰ和ＥＤＴＭＰ的中毒剂量远大于临床参考剂量。     

虎杖苷对心肌细胞收缩性的影响

目的　探讨虎杖苷对心肌细胞收缩性的直接影响及其作用机制。方法　原代培养幼鼠心肌细胞 ,利用计算机图象分析系统测定虎杖苷处理后心肌细胞收缩频率和收缩幅度的变化。结果　当加入 0 1mmol·L-1虎杖苷到培养细胞中时 ,心肌细胞收缩频率显著加快 ,收缩幅度增强 ;当加入洋地黄类药物西地兰时 ,心肌细胞收缩幅度增强 ,搏动频率也加快。而加入D Hanks液的对照组心肌细胞搏动情况在 30min内未发生变化。给予虎杖苷后 ,心肌细胞内钙荧光强度呈现进行性上升趋势 ,上升到最初的 2 2 4 0 %± 2 4 33%。结论　虎杖苷可能通过促使心肌细胞内钙离子浓度升高而直接增强心肌细胞的收缩性     

来曲唑方案用于不同年龄多囊卵巢综合征患者促排卵疗效比较

目的：比较来曲唑方案对不同年龄多囊卵巢综合征（ PCOS）促排卵的临床疗效。方法回顾性分析来曲唑（ LE）方案促排卵治疗的56例PCOS患者资料共68个周期。按年龄分为高龄组（≥35岁）、低龄组（≤28岁）。比较HCG注射日两组患者子宫内膜厚度、形态、优势卵泡数、排卵数及妊娠率。结果高龄组与低龄组相比,子宫内膜厚度为（7．9±1．7）mm 与（9．4±3．2）mm,差异有统计学意义（t＝2．648,P＜0.05）,AB型子宫内膜率71．9％与77．8％、优势卵泡数（1．5±1．5）个与（1．4±1．2）个、排卵数个（1．3±0．8）个与（1．4±1.2）个,妊娠率（37．5％与27．8％）差异无统计学意义（ t＝2．456、1．995、1．758、1．525,均P＞0.05）。结论 LE方案对不同年龄PCOS患者同样有效,虽然高龄患者子宫内膜厚度低于年轻患者,但优势卵泡数、形态、排卵数无别,并不降低其妊娠率。     

球囊复位终板椎体增强结合经皮椎弓根螺钉固定治疗胸腰椎爆裂性骨折北大核心CSCD

Objective: To investigate the clinical results of percutaneous balloon-assisted endplate reduction reinforced by injectable calcium sulfate cement (CSC) after fixation with percutaneous pedicle screws in the treatment of thoracolumbar burst fractures. Methods: From January 2016 to December 2018, 23 patients were treated at Department of Orthopaedics, The Second People's Hospital of Hefei for thoracolumbar burst fractures without neural impairment (LSC>6). They were 14 males and 9 females, aged from 20 to 60 years (average, 43 years). After reduction and fixation of the injured vertebrae with percutaneous pedicle screws, the collapsed endplates were reset by transpedicular balloon and reinforced by injectable CSC. Recorded were operation time, bleeding volume, fracture healing, visual analogue scale (VAS), anterior height ratio of the injured vertebra, central height ratio of the injured vertebra, sagittal cobb angle, absorption of CSC and complications. Results: The operation time averaged 110 min and the bleeding volume 75 mL. This group of patients obtained follow-up for 12 to 48 months (average, 24 months). The mean time for CSC complete absorption was 3 months postoperatively. The VAS scores for back pain at 3 days postoperation and the last follow-up (2.1±0.9 and 1.1±0.3) were significantly improved than the preoperative value (7.8±1.3);the anterior height ratios of the injured vertebra (93.22%±6.39%, 92.79%±6.41% and 92.38%±6.60%), the central height ratios of the injured vertebra (90.66%±6.28%, 89.92%±6.05% and 86.54%±6.96%) and the sagittal cobb angles (4.88°±2.35°, 5.32°±2.34° and 5.84°±2.43°) at postoperative 1 week, 3 months and the last follow-up were significantly improved than the preoperative values (51.68%±8.32%, 63.37%±9.24% and 20.77°±7.35°, respectively) (P<0.05), but there was no significant difference between the 3 time points (P>0.05). Internal fixation failure or loss of cobb angle greater than 10° was found in none of the patients. Conclusions: Percutaneous balloon-assisted endplate reduction reinforced by injectable CSC combined with percutaneous pedicle screwing is a safe and minimally invasive treatment of thoracolumbar burst fractures with LSC>6, leading to effective reduction of the collapsed endplate and restoration of vertebral mechanical performance. © 2020 Chinese Medical Association