自噬、TGF-β_1在宫颈癌中的研究进展

宫颈癌作为我国发病率最高的生殖系统恶性肿瘤,其发病机制复杂。自噬是细胞内溶酶体降解蛋白和细胞器来维持细胞稳态的重要分子途径,参与各种病理及生理过程。TGF-β作为一种多肽类生长因子,负责细胞发育、生长、分化及迁移和凋亡。二者均参与宫颈癌的发生与发展,或可相互作用共同影响宫颈癌的发生。     

外探倒钩术式在肛瘘、肛周脓肿手术中应用的疗效分析

目的 对外探倒钩术式在肛瘘、肛周脓肿手术中应用的疗效进行临床观察研究。方法 我们于2003年2月-2007年4月，对144例肛瘘、肛周脓肿患者按就诊时间（单、双日）随机分为新式疗法组和传统疗法组，新式疗法组手术中采用外探倒钩术式，传统疗法组采用传统外探法，对两组患者术后的治愈例数、复发例数、复发率、创面愈合天数、术后并发症进行比较分析。结果 新式疗法组治愈76例，复发4例，复发率5．0％；传统疗法组治愈54例，复发10例，复发率15．6％，经统计学分析，差异有统计学意义（0．05〉P〉0．01）。愈合天数、术后并发症比较差异无统计学意义（P〉0．05）。结论 外探倒钩术式对于肛瘘、肛周脓肿的治疗，具有明显优势，能准确地探寻到内口，防止内口遗漏，极大地降低了肛瘘、肛周脓肿的复发率，是手术治疗舡瘘、肛周脓肿的好方法。     

ICU设备配置要领

与普通设备相比，ICU的设备更与生命息息相关，因此它的配置应以满足需要、便于抢救、减少污染为原则。     

天津市和平区全球基金流动人口结核病防治项目实施效果分析

社会流动已经是普遍的现象,流动人口因其受知识缺乏、经济状况、环境等影响已成为结核病传播的高风险人群,极易感染结核病。在结核病的传播和流行中,流动人口的数量和范围日益扩大是一个非常重要的促进因素[1]。流动人口结核病患病率高、治疗管理困难,已成为我国结核病防治规划亟待解决的问题     

脑梗死患者颈动脉的超声表现探讨

颈动脉粥样硬化是脑梗死的重要危险因素，它与脑梗死的发生与发展密切相关。本文旨在利用彩超探讨缺血性脑卒中患者颈动脉形态特征，内-中膜厚度（IMT），斑块的有无，血管狭窄程度的超声表现，以期达到早期预报和识别缺血性脑卒中的目的。     

闭合复位及撬拨法在椎体成形术中的应用

Objective To discuss the effects of closed reduction and levering manipulation on ver-tebral height restoration and kyphosis correction in vertebroplasty for osteoporotic compression fractures. Methods From January 2005 to June 2007, a total of 38 patients with osteoporotic vertebral compression fractures were treated with vertebroplasty. In closed reduction, a transfixion pin was used to lever the collapsed vertebral endplate through the pedicle. Before and after surgery, pain relief and functional improvement were evaluated using a visual analogue scale (VAS) and the Oswestry' s disability index (ODI). Changes in ver-tebral height and kyphotic angle and distribution of bone cement in the vertebral body were observed by Lee's method. Results All patients were followed up for 6 to 24 (average, 13.4) months. The average VSA scores were reduced from preoperative 8.6±2.3 to postoperative 3.8±2.6. The average ODI scores reduced from preoperative 64.8% to postoperative 48.7%. The differences were of statistical significance. The average increase in vertebral body height was 5.8 mm anteriorly, 6.6 mm centrally, and 1.0 mm posteriorly. The mean reduction in the kyphosis angle was 9.7 degrees. The percentages of restoration of vertebral height were 54.6% at the anterior border, 58.1% at the center, and 46.5% at the posterior border. The differences were of sta-tistical significance between preoperation and postoperation. Conclusion Closed reduction and levering manipulation is effective in vertebroplasty for osteoporotie vertebral compression fractures.     

国产舒芬太尼辅助硬膜外麻醉用于阑尾切除术的观察

腹部手术选用连续硬膜外阻滞可提供满意的镇痛和肌松效果，但难以消除手术中内脏牵拉反应及患者的紧张情绪，术中常需辅助静脉用药。本研究观察了国产舒芬太尼用于硬膜外阻滞对于阑尾切除手术中牵拉反应防治作用的效果，现报道如下。     

建立和完善党代表大会代表旁听党委常委会议制度研究

中共上海中医药大学党委贯彻落实党的十七大和十七届四中全会精神,为＂落实和完善党代表大会代表任期制＂,建立了＂党代表大会代表旁听党委常委会议制度＂。就建立该制度的现实意义、实践探索、主要经验进行了分析和总结;并通过调查研究,找出瓶颈问题,提出机制建设,以保障＂党代表大会代表旁听党委常委会议制度＂得以坚持、不断完善。     

护理干预对大肠造口患者生活质量的影响

目的:通过适当的护理干预提高大肠造口患者的生活质量。方法:随机选择100例大肠造口患者从入院、术前、术后到出院以及术后1年进行随访,针对不同阶段提供相应的护理干预。结果:患者能够从心理、生理上对大肠造口护理有良好的认知,并且能够对造口进行恰当的自我护理,从而减少术后并发症的发生率,提高生活质量。结论:适当的护理干预能够有效地提高大肠造口患者的生活质量。     

PROGNOSTIC VALUE OF ELECTROENCEPHALO-GRAPHY BACKGROUND ACTIVITIES IN ASPHYXIATED NEONATES

Objective To identify the changes in the electroencephalography (EEG) background activities in asphyxiated neonates and to determine the prognostic value of these changes in neurological outcomes.Methods A total of 46 asphyxiated neonates and 31 healthy newborns were studied using standard EEG.Forty-three neonates from the asphyxiated group were followed up and had neurological examinations and developmental assessments at 3,6,9 and 12 months of age.The parameters that had prognostic significance were stati...