全文获取类型
收费全文 | 1939篇 |
免费 | 133篇 |
国内免费 | 5篇 |
学科分类
医药卫生 | 2077篇 |
出版年
2023年 | 21篇 |
2022年 | 21篇 |
2021年 | 60篇 |
2020年 | 40篇 |
2019年 | 53篇 |
2018年 | 51篇 |
2017年 | 39篇 |
2016年 | 54篇 |
2015年 | 62篇 |
2014年 | 77篇 |
2013年 | 102篇 |
2012年 | 143篇 |
2011年 | 158篇 |
2010年 | 109篇 |
2009年 | 81篇 |
2008年 | 124篇 |
2007年 | 145篇 |
2006年 | 127篇 |
2005年 | 119篇 |
2004年 | 93篇 |
2003年 | 90篇 |
2002年 | 99篇 |
2001年 | 14篇 |
2000年 | 7篇 |
1999年 | 16篇 |
1998年 | 14篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 6篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 5篇 |
1978年 | 4篇 |
1976年 | 9篇 |
1974年 | 8篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1969年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有2077条查询结果,搜索用时 15 毫秒
61.
OBJECTIVES: The study objectives were: (a) to evaluate knowledge about osteoporosis and to identify its correlates among women > or =40 years of age attending outpatient centers; (b) to compare the level of knowledge between women already receiving treatment for osteoporosis and first-time attendees. METHODS: A cross-sectional survey was conducted with women recruited from nine outpatient centres in the Czech Republic. The women were divided into two subgroups: patients who have already been diagnosed with osteoporosis (osteopenia) and who are receiving treatment for the disease (OS group); first-time attendees who have been referred for the assessment of osteoporosis (comparison group). The patient's knowledge of osteoporosis was assessed using the Osteoporosis Questionnaire (OPQ) developed by Pande et al. [Pande KC, Takats D, Kanis JA, Edwards V, Slade P, McCloskey EV. Development of a questionnaire (OPQ) to assess patient's knowledge about osteoporosis. Maturitas 2000;37:75-81]. RESULTS: A total of 474 women (median age 63 years) were studied (306 in the OS group, 168 in the comparison group). Knowledge scores based on OPQ (median) were 7 and 6 points in the OS and comparison groups, respectively. When adjusted for age, the statistics showed better knowledge patients in the OS group (P=0.019). In both the OS and comparison groups, knowledge was found to be correlated positively with education (P<0.001) and experience of hormone replacement therapy (HRT) (P<0.001) and negatively with age (P<0.001). Knowledge was higher among women with better health status in the OS group. CONCLUSION: Knowledge about osteoporosis among Czech women aged > or =40 years and attending outpatient centers is relatively poor. To improve it, special attention should be paid to elderly women, those who have not used HRT, poorly educated women and those treated with several drugs. 相似文献
62.
63.
OBJECTIVE: To evaluate the effect of a miniaturized extracorporeal circulation system (MECC System) compared to conventional extracorporeal circulation (ECC) regarding liver function in cardiac surgical patients. METHODS: Double indicator dilution measurements were achieved by bolus injection of indocyanine green (ICG) for assessment of cardiac index (CI) and plasma disappearance rate of ICG (PDRig). Measurements were simultaneously performed preoperatively after induction of anaesthesia (T1), following admission on the ICU (T2) and 6 h postoperatively (T3). RESULTS: CI and PDRig were markedly increased after cardiac surgery without significant differences between groups. The percentage increase in CI was significantly correlated to the percentage increase in PDRig in both groups. CONCLUSION: Liver function improved after cardiac surgery in both groups of patients, which may partly be explained by an increase in CI under mild inotrope support. Differences between the extracorporeal circuits with respect to PDRig appear to be minimal in a group of patients without pre-existing liver injury. 相似文献
64.
Shibli JA Grassi S de Figueiredo LC Feres M Iezzi G Piattelli A 《Implant dentistry》2007,16(3):252-259
PURPOSE: The aim of this study was to evaluate the influence of oxidized surface on bone-to-implant contact percentage (BIC%) as well as the bone density within the threads area (BD%) in human bone after 2 months of unloaded healing. MATERIALS: Seven subjects (mean age 45.57 +/- 10.45 years) received 2 micro-implants each during conventional implant surgery in the posterior maxilla. The implants that presented turned and oxidized surfaces served as control and test, respectively. After the healing period, the implants and the surrounding tissue were removed and prepared for ground sectioning and analysis. RESULTS: Two turned implants were found to be clinically unstable at the time of retrieval. Histometric evaluation showed that the mean of BIC% was 17.40 +/- 14.16% and 32.19 +/- 15.68% to turned and oxidized surfaces, respectively. The BD% was 22.13 +/- 19.06% for turned surface and 50.40 +/- 18.35% for oxidized surface. CONCLUSION: The histologic data from this preliminary study suggest that the oxidized micro-implants surface presented better mean values of BIC% and BD% than turned micro-implants after a short healing time. 相似文献
65.
Tranos Paris G. Allan Bruce Balidis Miltiadis Vakalis Athanasios Asteriades Solon Anogeianakis George Triantafilla Magda Kozeis Nikolaos Stavrakas Panagiotis 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(5):987-993
Graefe's Archive for Clinical and Experimental Ophthalmology - To investigate the accuracy of preoperative biometry in eyes undergoing combined phacovitrectomy and to compare it with eyes... 相似文献
66.
Alexandre de Matos Soeiro Felipe Louren?o Fernandes Rafael Plens Teixeira Pedro Felipe Gomez Nicz Maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares de Oliveira Jr. 《Brazilian Journal Of Cardiovascular Surgery》2014,29(2):285-288
Insertion of inferior vena cava filters has been well established in literature,
reducing occurrence of pulmonary embolism after an episode of deep venous thrombosis
in patients with contraindication to anticoagulation. There are a small number of
complications related to procedure and embolization is rare. In this context, we
described a case of intracardiac embolization associated with cardiac tamponade. 相似文献
67.
Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase
下载免费PDF全文
![点击此处可从《Blood》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Gardembas M Rousselot P Tulliez M Vigier M Buzyn A Rigal-Huguet F Legros L Michallet M Berthou C Cheron N Maloisel F Mahon FX Facon T Berthaud P Guilhot J Guilhot F;CML French Group 《Blood》2003,102(13):4298-4305
In chronic myelogenous leukemia (CML) imatinib mesylate has been shown to selectively inhibit the tyrosine kinase domain of the oncogenic bcr-abl fusion protein. Using this agent alone high rates of cytogenetic responses were recorded. However, several mechanisms of resistance have been described. In vitro studies examining the effects of imatinib mesylate plus cytarabine have shown synergistic antiproliferative effects of this combination. Thus, the CML French Group decided to perform a phase 2 trial testing a combination of imatinib mesylate and low-dose cytarabine in 30 previously untreated patients in chronic phase. Treatment was administered on 28-day cycles. Patients were treated continuously with imatinib mesylate orally at a dose of 400 mg daily. Cytarabine was given on days 15 to 28 of each cycle at an initial dose of 20 mg/m2/d via subcutaneous injection. Adverse events were frequently observed with grade 3 or 4 hematologic toxicities and nonhematologic toxicities in 53% (n = 16) and 23% (n = 7) of patients, respectively. The cumulative incidence of complete cytogenetic response (CCR) at 12 months was 83% and at 6 months 100% of the patients achieved complete hematologic response (CHR). We concluded that the combination was safe and promising given the rates of response. 相似文献
68.
Maurizio Zizzo Carolina Castro Ruiz Magda Zanelli Maria Chiara Bassi Francesca Sanguedolce Stefano Ascani Valerio Annessi 《Medicine》2020,99(48)
Background:Acute colonic diverticulitis (ACD) complications arise in approximately 8% to 35% patients and the most common ones are represented by phlegmon or abscess, followed by perforation, peritonitis, obstruction, and fistula. In accordance with current guidelines, patients affected by generalized peritonitis should undergo emergency surgery. However, decisions on whether and when to operate ACD patients remain a substantially debated topic while algorithm for the best treatment has not yet been determined. Damage control surgery (DCS) represents a well-established method in treating critically ill patients with traumatic abdomen injuries. At present, such surgical approach is also finding application in non-traumatic emergencies such as perforated ACD. Thanks to a thorough systematic review of the literature, we aimed at achieving deeper knowledge of both indications and short- and long-term outcomes related to DCS in perforated ACD.Methods:We performed a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines. Pubmed/MEDLINE, Embase, Scopus, Cochrane Library, and Web of Science databases were used to search all related literature.Results:The 8 included articles covered an approximately 13 years study period (2006–2018), with a total 359 patient population. At presentation, most patients showed III and IV American Society of Anesthesiologists (ASA) score (81.6%) while having Hinchey III perforated ACD (69.9%). Most patients received a limited resection plus vacuum-assisted closure at first-look while about half entire population underwent primary resection anastomosis (PRA) at a second-look. Overall morbidity rate, 30-day mortality rate and overall mortality rate at follow-up were between 23% and 74%, 0% and 20%, 7% and 33%, respectively. Patients had a 100% definitive abdominal wall closure rate and a definitive stoma rate at follow-up ranging between 0% and 33%.Conclusion:DCS application to ACD patients seems to offer good outcomes with a lower percentage of patients with definitive ostomy, if compared to Hartmann''s procedure. However, correct definition of DCS eligible patients is paramount in avoiding overtreatment. In accordance to 2016 WSES (World Society of Emergency Surgery) Guidelines, DCS remains an effective surgical strategy in critically ill patients affected by sepsis/septic shock and hemodynamical unstability. 相似文献
69.
70.
Harrison Mark Bansback Nick Aguiar Magda Koehn Cheryl Shojania Kam Finckh Axel Hudson Marie 《Clinical rheumatology》2020,39(10):2931-2941
Clinical Rheumatology - To elicit and compare preferences of patients and first-degree relatives and rheumatologists for preventive treatments for rheumatoid arthritis, understand the... 相似文献