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uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues 总被引：10，自引：0，他引：10 
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下载免费PDF全文 Meng S Tripathy D Shete S Ashfaq R Saboorian H Haley B Frenkel E Euhus D Leitch M Osborne C Clifford E Perkins S Beitsch P Khan A Morrison L Herlyn D Terstappen LW Lane N Wang J Uhr J 《Proceedings of the National Academy of Sciences of the United States of America》2006,103(46):17361-17365
Overexpression of urokinase plasminogen activator system or HER-2 (erbB-2) in breast cancer is associated with a poor prognosis. HER-2 overexpression is caused by HER-2 gene amplification. The anti-HER-2 antibody trastuzumab significantly improves clinical outcome for HER2-positive breast cancer. Drugs that target the uPA system are in early clinical trials. The aims of this study were to determine whether urokinase plasminogen activator receptor (uPAR) gene amplification occurs and whether analysis of individual tumor cells (TCs) in the blood or tissue can add information to conventional pathological analysis that could help in diagnosis and treatment. Analysis of individual TCs indicates that uPAR amplification occurs in a significant portion of primary breast cancers and also circulating tumor cells (CTCs) from patients with advanced disease. There was complete concordance between touch preps (TPs) and conventional pathological examination of HER-2 and uPAR gene status in primary tumors. There was also excellent concordance of HER-2 gene status between primary tumors and CTCs provided that acquisition of HER-2 gene amplification in CTCs was taken into account. Unexpectedly, gene amplification of HER-2 and uPAR occurred most frequently in the same TC and patient, suggesting a biological bias and potential advantage for coamplification. Expression of HER-2 and uPAR in primary tumors predicted gene status in 100 and 92% of patients, respectively. 相似文献
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Abhijeet Bhatia Pranjal Pratim Saikia Barilin Dkhar Haphidasara Pyngrope 《动物模型与实验医学（英文）》2022,5(2):183
ObjectiveTo formulate an anesthesia protocol for safe and satisfactory anesthesia for ear surgery in rats.MethodsThe rats were anesthetized with xylazine (10 mg/kg body weight) and ketamine at doses of 80, 50, 40, and 30 mg/kg body weight or with isoflurane anesthesia (2%–3.5% in 100% oxygen; maintenance dose 1.5%–3.5%). The anesthesia induction, surgery, and recovery time were recorded.ResultsIn total, 17 rats were induced by varying doses of ketamine‐xylazine and 28 rats with isoflurane. Mean induction time with ketamine‐xylazine was 6 ± 2.9 min compared with 3.8 ± 1.1 min with isoflurane. Mean recovery time with ketamine‐xylazine was 142.6 ± 49.3 min compared with 4.1 ± 1.2 min with isoflurane. A mortality of 4 animals after developing dyspnea was recorded with ketamine‐xylazine.ConclusionIsoflurane anesthesia offers appropriate induction and recovery times and low mortality rates for the surgeries performed. Isoflurane anesthesia offers reliable results for ear surgery in rats. However, more equipment and technical skills are needed. 相似文献
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Abhijeet Kumar Jha Keshavamurthy Vinay Martyna S&#x;awi&#x;ska Sidharth Sonthalia Micha&#x; Sobjanek Grazyna Kami&#x;ska‐Winciorek Enzo Errichetti Divya Kamat Debajyoti Chatterjee Zoe Apalla Iris Zalaudek Mohamad Goldust Aimilios Lallas 《Dermatologic therapy》2021,34(1):e14478
Dermoscopy of mucosal surface termed “mucoscopy” is an upcoming offshoot of dermatological imaging. However, the literature on mucoscopy is limited to individual cases and small case series. An organized review or systematic analysis of mucoscopy is lacking. The aim of this review was to summarize the published literature on mucoscopic features of benign conditions affecting the oral mucosa and semi‐mucosa. Additionally, the results of mucoscopic features of diseases, which have not been described before have been presented. 相似文献
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Soham D. Puvvada José Guillen-Rodriguez Abhijeet Kumar Lora Inclán Kara Heard Xavier I. Rivera Faiz Anwer Jonathan H. Schatz Daruka Mahadevan Daniel O. Persky 《Clinical Lymphoma, Myeloma & Leukemia》2018,18(1):58-64
Background
Mantle-cell lymphoma (MCL) and indolent non-Hodgkin lymphoma (iNHL) are incurable heterogeneous diseases characterized by relapse. There is a need for newer treatments in MCL and iNHL, especially in the relapsed/refractory (R/R) setting. We therefore investigated the novel combination of bortezomib (Velcade), cladribine, and rituximab (VCR) in front-line and R/R settings in MCL and iNHL (NCT00980395).Patients and Methods
Eligible patients included adults with biopsy-proven CD20-positive MCL and iNHL who met the criteria for treatment. Rituximab 375 mg/m2 intravenous (IV) day 1, cladribine 4 mg/m2 IV days 1 to 5, and bortezomib 1.3 mg/m2 IV days 1 and 4 were administered every 28 days for 6 cycles.Results
Twenty-four patients were enrolled onto the study with a median follow-up of 38.5 months. Median age was 66.5 years, and 46% had MCL. The most common adverse events were hematologic, with febrile neutropenia in 3 patients. Neuropathy was noted in 17% of patients, of which 8% was grade 3 or above. The overall response rate was 92%. For the entire cohort, and for MCL patients, the median progression-free survival and the median overall survival were not reached. The 2-year progression-free survival was 82% for the MCL group and 54% for the iNHL group; it was 80% for treatment-naive patients and 57% for R/R patients.Conclusion
VCR is effective in MCL and iNHL. Although hematologic toxicity can be an issue, this study demonstrates a high response rate to a novel combination and provides an alternative option in transplant-ineligible R/R MCL and iNHL. 相似文献86.
Abhijeet Botre Vrajesh Udani Neelu Desai Spoorthy Jagadish Milind Sankhe 《Indian pediatrics》2017,54(8):678-680
Background
Management of refractory status epilepticus in children is extremely challenging.Case characteristics
Two children with medically refractory status epilepticus, both of whom had lesional pathology on MRI and concordant data on EEG and PET scan.Intervention
Emergency hemispherotomy performed in both patients. A complete, sustained seizure freedom obtained postoperatively.Message
Emergency surgery is a treatment option in selected cases of drug refractory status epilepticus with lesional pathology and concordant data.87.
Anomalous orbital structures are suspected in restrictive strabismus with features of severe globe retractions, overshoots, or synergistic movements. We report a case of suspected Duane syndrome that was found to have an anomalous band beneath the lateral rectus muscle. Such abnormal structures are rare, but it is important to identify and manage them to optimize outcomes. 相似文献
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