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Rich-Garg Neha Danve Abhijeet Choi Dongseok Vakil-Gilani Kiana Akkoc Nurullah Azevedo Valderillo Russell Anthony Sharma Aman Cush John Curtis Jeffery R. Deodhar Atul 《Clinical rheumatology》2021,40(3):949-954
Clinical Rheumatology - This study aims to assess rheumatologists’ perceptions, utilization patterns, and attitudes towards the modified New York (mNY) criteria for ankylosing spondylitis... 相似文献
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Abhijeet Ashok Salunke Yongsheng Chen Jun Hao Tan Xi Chen Tun-Lin Foo Louise Elizabeth Gartner Mark Edward Puhaindran 《Singapore medical journal》2015,56(10):555-557
INTRODUCTION
Schwannomas that arise within the muscle plane are called intramuscular schwannomas. The low incidence of these tumours and the lack of specific clinical features make preoperative diagnosis difficult. Herein, we report our experience with intramuscular schwannomas. We present details of the clinical presentation, radiological diagnosis and management of these tumours.METHODS
Between January 2011 and December 2013, 29 patients were diagnosed and treated for histologically proven schwannoma at the National University Hospital, Singapore. Among these 29 patients, eight (five male, three female) had intramuscular schwannomas.RESULTS
The mean age of the eight patients was 40 (range 27–57) years. The most common presenting feature was a palpable mass. The mean interval between surgical treatment and the onset of clinical symptoms was 17.1 (range 4–72) months. Six of the eight tumours (75.0%) were located in the lower limb, while 2 (25.0%) were located in the upper limb. None of the patients had any preoperative neurological deficits. Tinel’s sign was present in one patient. Magnetic resonance (MR) imaging showed that the findings of split-fat sign, low signal margin and fascicular sign were present in all patients. The entry and exit sign was observed in 4 (50.0%) patients, a hyperintense rim was observed in 7 (87.5%) patients and the target sign was observed in 5 (62.5%) patients. All patients underwent microsurgical excision of the tumour and none developed any postoperative neurological deficits.CONCLUSION
Intramuscular schwannomas demonstrate the findings of split-fat sign, low signal margin and fascicular sign on MR imaging. These findings are useful for the radiological diagnosis of intramuscular schwannoma. 相似文献14.
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D. Scott Lim MD Robert L. Smith MD Firas Zahr MD Abhijeet Dhoble MD Roger Laham MD Mohamad Lazkani MD Susheel Kodali MD Chad Kliger MD James Hermiller MD Amit Vora MD Ian J. Sarembock MB ChB MD William Gray MD Samir Kapadia MD Adam Greenbaum MD Andrew Rassi MD David Lee MD Adnan Chhatriwalla MD Pinak Shah MD Josep Rodés-Cabau MD Homam Ibrahim MD Lowell Satler MD Howard C. Herrmann MD Paul Mahoney MD Charles Davidson MD George Petrossian MD Mayra Guerrero MD Konstantinos Koulogiannis MD Leo Marcoff MD Linda Gillam MD The CLASP IID Pivotal Trial Investigators 《Catheterization and cardiovascular interventions》2021,98(4):E637-E646
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Liu E Percy MJ Amos CI Guan Y Shete S Stockton DW McMullin MF Polyakova LA Ang SO Pastore YD Jedlickova K Lappin TR Gordeuk V Prchal JT 《Blood》2004,103(5):1937-1940
The first congenital defect of hypoxia-sensing homozygosity for VHL 598C>T mutation was recently identified in Chuvash polycythemia. Subsequently, we found this mutation in 11 unrelated individuals of diverse ethnic backgrounds. To address the question of whether the VHL 598C>T substitution occurred in a single founder or resulted from recurrent mutational events in human evolution, we performed haplotype analysis of 8 polymorphic markers covering 340 kb spanning the VHL gene on 101 subjects bearing the VHL 598C>T mutation, including 72 homozygotes (61 Chuvash and 11 non-Chuvash) and 29 heterozygotes (11 Chuvash and 18 non-Chuvash), and 447 healthy unrelated individuals from Chuvash and other ethnic groups. The differences in allele frequencies for each of the 8 markers between 447 healthy controls (598C) and 101 subjects bearing the 598T allele (P < 10(-7)) showed strong linkage disequilibrium. Haplotype analysis indicated a founder effect. We conclude that the VHL 598C>T mutation, the most common defect of congenital polycythemia yet found, was spread from a single founder 1,000 to 62,000 years ago. 相似文献
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Poojita Shivamurthy MD Pimprapa Vejpongsa MD Sidhanta Gurung MD Robin Jacob MD Yelin Zhao PhD H. Vernon Anderson MD Prakash Balan MD Tom C Nguyen MD Anthony L Estrera MD Anne H Dougherty MD Richard W Smalling MD PhD Abhijeet Dhoble MD MPH 《Pacing and clinical electrophysiology : PACE》2020,43(5):479-485
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Kolk SM Whitman MC Yun ME Shete P Donoghue MJ 《Molecular and cellular neurosciences》2005,30(4):538-551
Cells of the subplate (SP) and deep cortical plate (CP) are among the pioneer neurons of the developing cerebral cortex, an important group of early-born cells that impact cortical organization and function. Similarities between pioneer neurons in different cortical positions and heterogeneities in pioneer cells in the same cortical location, however, have made it difficult to appreciate the characteristics and functions of particular sets of these cells. Here, we provide a tool to illuminate a unique subset of SP and deep CP neurons: expression of a Tbrain-1 (Tbr1)-driven transgene. Transgene-expressing cells were consistently positive for neuronal but not glial markers, were born early in corticogenesis, representing just a subset of SP and deep CP neurons, were morphologically complex during the formation of the cortex, and were maintained into maturity. This analysis reveals a novel group of pioneer neurons and demonstrates unrecognized diversity within this cortical population. In the future, this information will help to uncover the roles of discrete pioneer populations in cortical development. 相似文献