四川CNG汽车城际化运行效益评价与发展对策

在国家提出节能减排、发展低碳经济和我国石油对外依存度不断攀升的大背景下,CNG汽车运行由城市内向城际化扩展是缓解石油紧缺、发展低碳运输经济、减少尾气排放的一个重要途径。通过构建社会、经济和环境效益的评价指标和指标体系,运用主成分方法对四川试验区CNG汽车发展进行了评价。结果表明,四川试验区发展CNG汽车具有良好的社会效益、经济效益和环境效益。进而提出了规模化推广CNG汽车城际化运行的建议：①加快干线公路CNG加气站建设和制订城际化营运的安全、技术保障规程,加强安全监管;②用财税政策扶持和促进CNG汽车城际化营运;③加强CNG汽车关键技术研发,提高CNG汽车城际化运行的安全性和经济性。     

浅议城市遥感综合调查——以南京为例

概要介绍了城市遥感技术及开展城市遥感综合调查的意义、内容和方法,并提出南京市开展城市遥感综合调查的立顶设想（立顶建议）。     

应用超定模型识别模态参数的时域方法

本文在文[16]的基础上进一步讨论了应用超定模型,直接根据系统的衰减响应识别结构的模态参数的一般算法;并从数值上对于一些主要方法的识别能力进行了比较.     

控制系统校正网络参数最优化的计算机辅助设计

本文介绍一种由计算机实现的控制系统校正网络参数最优化的设计方法,算法简单、收敛、便于工程应用.经过计算机迭代计算后所设计的校正网络,在给定频率点上的幅相特性与期望校正特性趋于一致.该方法已在工程设计中使用.     

Comments on “Solutions to the combined sensitivity andcomplementary sensitivity problem in control systems”

In the above-mentioned paper by Lim et al. (1996) a numerical example is given to show that the Nevanlinna-Pick interpolation formulas appearing in Khargonekar and Tannenbaum (1985) and Krein and Nudel'man (1977) are incorrect. By comparing the paper of Krein and Nudel'man with Adamjan (1971) we illustrate that the correct formulas are obtained by simply taking the transpose of the Pick matrix given in the first two above mentioned papers     

In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor

Epidermal growth factor receptor (EGFR)-associated protein tyrosine kinase (PTK) complexes have vital anti-apoptotic functions in human breast cancer cells. We have shown previously that targeting the naturally occurring PTK inhibitor genistein to the EGFR-associated PTK complexes using the EGF-Genistein (Gen) conjugate triggers rapid apoptotic cell death in human breast cancer cells and abrogates their in vitro clonogenic growth. In the present study, we examined the in vivo toxicity profile, pharmacokinetics, and anticancer activity of EGF-Gen. No toxicities were observed in mice treated with EGF-Gen at dose levels as high as 40 mg/kg administered i.p. as a single dose or 140 mg/kg administered i.p. over 28 consecutive days. EGF-Gen significantly improved tumor-free survival in a severe combined immune deficiency (SCID) mouse xenograft model of human breast cancer, when it was administered 24 h after inoculation of tumor cells. At 100 microg/kg/day x 10 days (1 mg/kg total dose), which is >100-fold less than the highest tested and nontoxic cumulative dose (ie., 140 mg/kg) in mice, EGF-Gen was more effective than cyclophosphamide (50 mg/kg/day x 2 days), Adriamycin (2.5 mg/kg x 1 day), or methotrexate (0.5 mg/kg x 1 day), the most widely used standard chemotherapeutic drugs for breast cancer, and resulted in 60% long-term tumor-free survival. Furthermore, treating SCID mice with established s.c. human breast cancer xenografts of 0.5-cm diameter with EGF-Gen at this dose level resulted in disappearance of the tumors in two of five mice and >50% shrinkage in three of five mice within 10 days, whereas all of the control tumors in five PBS-treated mice as well as five mice treated with unconjugated Gen (1 mg/kg/day x 10 days) showed >200% increase in diameter during the same observation period. EGF-Gen treatment reduced the growth rate of breast cancer xenografts of 1.0-cm diameter, but unlike with tumors of 0.5-cm diameter, it failed to cause shrinkage or disappearance of these larger tumors. The level of EGF-Gen systemic exposure that was effective in SCID mice was achieved in cynomolgus monkeys without any significant side effects detectable by clinical observation, laboratory studies, or histopathological examination of multiple organs. EGF-Gen might be useful in the treatment of breast cancer as well as other EGFR-positive malignancies.     

In vivo toxicity and pharmacokinetic features of B43(Anti-CD19)-Genistein immunoconjugate

B43(anti-CD19)-Genistein immunoconjugate targets genistein, a naturally occurring protein tyrosine kinase inhibitory isoflavone to the membrane-associated anti-apoptotic CD19-LYN complexes and triggers apoptotic cell death. In this preclinical study, the toxicity profiles of B43-Genistein as well as unconjugated genistein were evaluated in mice. B43-Genistein and genistein were administered either as single bolus injections or daily injections for 10 consecutive days via the intraperitoneal route to mice. Genistein was not toxic to mice at the highest dose of 40 mg/kg and no test article-related histopathological lesions were found in any of the 64 genistein-treated mice. B43-Genistein had a significantly longer elimination half-life and slower plasma and tissue clearance than unconjugated genistein. B43-Genistein was not toxic to mice at the highest single dose of 40 mg/kg or highest cumulative dose of 100 mg/kg and no test article-related histopathological lesions were found in any of the 108 mice treated with B43-genistein. To our knowledge, this is the first preclinical toxicity and pharmacokinetic study of a tyrosine kinase inhibitor-containing immunoconjugate.     

基于改进回声状态网络的游离氧化钙预测控制

在非线性时延水泥烧成系统中,针对传统预测控制方法调节时间长、控制精度不高的问题,提出一种改进的在线型回声状态网络预测控制模型。首先将带有L1范数约束项的递归最小二乘法与回声状态网络相结合构建在线型预测模型,解决传统预测控制模型辨识精度较低、无法进行实时预测的问题;然后基于改进的回声状态网络预测模型,构建预测控制模型结构,并采用具有全局优化能力的粒子群算法进行滚动优化,保证实际输出量快速、准确、平稳地跟随被控量的设定值;最后利用改进的预测控制模型对水泥烧成系统中的游离氧化钙含量进行预测控制仿真实验,结果表明改进的预测控制模型具有良好的性能和应用前景。     

Spontaneous ring-like self-assembly of BaF2 nanoparticles

Self-assembly of BaF2 nanoparticles was described. BaF2 nanoparticles were prepared by microemulsion technology. The self-assembly of the particles is spontaneous without coating reagent on the surface or external force being applied during the procedure of sample preparation. XRD examination and ICP data showed the phase purity of the final product; FTIR spectroscopy confirmed that there was no organic species leaved in the product. By depositing one drop of colloid solution containing BaF2 particles on the TEM grid directly, we can get the ring-like self-assembly with larger particles dispersing peripherally to form a ring and smaller particles inside this ring forming circles.