离子液体在药物晶体工程中的应用

近年来，使用离子液体替代传统溶剂参与调节结晶过程中的各种相互作用以获得新颖的晶体结构是药物晶体工程的研究前沿。研究人员在离子液体体系中得到了使用传统溶剂无法制得的药物晶型或晶习并进行了相应机理的初步探索。针对离子液体在药物晶体工程中的应用，本文从离子液体的组成和性质及其在药物增溶、药物晶型及晶习的调控和药物共晶及盐的制备几方面展开，首次综述了相关研究成果并基于红外光谱、分子动力学模拟等手段从相互作用的角度对机理进行分析，其中氢键和范德华力相互作用起到了重要影响。最后针对该领域现存的问题如离子液体的选择处于盲筛阶段，相应机理研究缺乏和应用范围不广泛，指出建立系统的离子液体选择标准和深入研究机理是未来的主要研究方向。     

Study on hardness and microstructural characteristics of sand cast Al-Si-Cu alloys

In this study, the influence of Cu content on the hardness and microstructural characteristics of sand cast Al-Si-Cu alloys have been investigated. Al-Si alloys with 2% and 5% Cu have been utilized for this purpose. Solidification of Al-Si-Cu alloys have been realized by melting in a gas furnace with a crucible and casting in green sand molds at 690°C. The solution treatment has been performed at 500°C for 7 h and then specimens were quenched in water. The samples have been aged at 190°C for 15 h to observe the effect of aging on mechanical properties.     

关于进一步发展我国资本市场的探讨

为了适应未来国民经济持续发展的需要,进一步发展完善我国资本市场对深化银行体系及投融资体制改革,促进对外开放有重大意义。通过对国外资本市场发展过程的考察,结合对我国国情的分析,我们认为,在未来几年里发展完善我国资本市场的思路应该是搞好基础证券市场和证券流通市场的建设。     

多尺度时空上下文目标跟踪

相关滤波器在视觉目标跟踪中得到了广泛应用,针对复杂场景下目标跟踪容易出现跟踪漂移的问题,以及现有多尺度跟踪算法计算量大的问题,本文提出一种实时的多尺度目标跟踪方法.首先由时空上下文模型输出目标位置置信图完成目标定位,再在尺度空间上训练相关滤波器完成目标尺度估计,最后基于目标位置和尺度提出了一种新的时空上下文模型更新机制,避免了模型更新错误.实验表明:该方法在尺度变化、局部遮挡、目标姿态变化等情况下均能完成鲁棒跟踪,跟踪正确率较原始时空上下文跟踪算法提高了38.4%.     

Instrumented indentation and scratch testing evaluation of tribological properties of tin-based bearing materials

This paper describes a study of some fundamental tribological behavior of two different tin-based bearing materials using scratch and Martens hardness techniques. The scratch test results obtained from the two different tin-based bearing materials were correlated with a function of scratch hardness and coefficient of friction. It is easily observed that the friction coefficients of WM5 are lower than those of WM2 under all scratch test conditions. Beside this, it is clearly distinguished that both materials give higher friction coefficients at higher normal loads and scratch velocities. Also it is found that scratch hardness values of the WM5 materials are higher than WM2 generally. Moreover, optical microscopy was used to determine the scratch hardness of two different tin-based bearing materials by examining the scratch widths. Scanning electron microscopic observations of two different tin-based bearing materials were performed in order to identify the scratch-deformation mechanisms and trace morphology. Beside scratch tests, Martens hardness tests were carried out to evaluate the indentation of materials by considering both the force and displacement during plastic and elastic deformation. By monitoring the complete cycle of increasing and removal of the test force, hardness values were determined.     

氮含量对BCN薄膜力学和摩擦学性能的影响

为获得能在较宽温度范围内工作的BCN薄膜,采用闭合场非平衡磁控溅射法制备出非晶态的BCN薄膜和BC_x薄膜,通过调控N₂流量研究氮含量对薄膜摩擦学和力学性能的影响。结果表明：BCN薄膜的硬度和弹性模量随着N₂流量的增加而降低;在室温至600℃较宽温度范围内,N₂流量小于20 sccm时制备的BCN薄膜具有更平稳的摩擦因数和低的磨损率,具有比BC_x薄膜更好的摩擦学性能。随着N元素的掺杂,BCN薄膜的力学性能降低,但摩擦学性能明显提高,因此通过改变氮含量实现BCN薄膜力学和摩擦学性能合理调控,BCN薄膜有望实现较宽温度范围内的减摩润滑作用。     

外翻肠囊法考察复合红花籽油的肠吸收特性

该研究旨在初步考察复合红花籽油的肠吸收特性。采用外翻肠囊法对其肠吸收部位、时间、给药浓度进行研究,通过气相色谱-质谱法（GC-MS）测定肠收集液中亚油酸（Linoleic Acid,LA）及α-亚麻酸（α-Linolenic Acid,ALA）含量,通过计算吸收转运参数、吸收速率参数分析其肠道转运机制。不同肠段中,其主要成分LA与ALA均能在十二指肠（LA:2.71 mg;ALA:1.60 mg）与空肠（LA:1.89 mg;ALA:1.43 mg）中被检出,通过计算不同部位透过药量（M）、药物吸收转化率（A）和药物剩余百分数（R）,结果显示十二指肠段中LA、ALA的M高于空肠段,A与空肠段接近,R低于空肠段,因此十二指肠为最佳吸收肠段。在120 min时,LA和ALA的Pappi（瞬时表观渗透系数）皆高于其他时间点,因此最佳吸收转运时间为120 min。在给药倍数为2.0倍时,肠囊液中的LA和ALA浓度最高,分别为0.35、0.19 mg/mL,因此最佳给药浓度为200 mg/mL。结果表明复合红花籽油的肠吸收特性可能为具有时间与浓度依赖性的被动运输模式且在十二指肠段中单向转运。     

变面积电涡流传感器带冠叶片振动测量

为实现对各种带冠叶片的振动的非接触式测量,提出一种基于变面积型电涡流传感器的带冠叶片振动测量技术.当转子叶片进行高速旋转时,叶片扫过电涡流传感器,会使感应面积发生变化,后接高速数据采集分析处理系统,将面积变化信号进行处理,从而获得带冠叶片振动参数.在某型汽轮机末级带冠叶片上进行振动试验,试验结果表明变面积型电涡流传感器...     

Synthesis and Fluorescence of Europium-Doped Barium Fluoride Cubic Nanocolumns

Europium-doped barium fluoride cubic nanocolumns were synthesized from the quaternary water in oil reverse microemulsions. In this process, the aqueous cores of water/cetyl trimethyl ammonium bromide (CTAB)/n-butanol/n-oe-tane reverse mieroemulsions were used as mieroreaetors for the precipitation of europium doped barium fluoride. XRD analysis shows that under the dopant concentration of 0.06% (molar fraction), the products are single phase. The result products are cubic column-like with about 30 - 50 nm edge length of cross section, and about 200 nm of length obtained from the transmission electron microscopy (TEM), and atomic force microscopy (AFM). Under the 0.06% (molar fraction) of dopant concentration, the fluorescence of Eu^2 and Eu^3 under the 589 of excitation wavelength is observed.     

2马力水下钕铁硼电机的特点及其在中型海洋机器人上的应用

本文介绍了我们研制的2马力水下钕铁硼电机与美国1马力电机相比所具有的特点,以及在研制中所遇到的难题及解决的方法,同时简要分析了水下钕铁硼电机在海洋机器人上的应用前景.