Loss of αA or αB-Crystallin Accelerates Photoreceptor Cell Death in a Mouse Model of P23H Autosomal Dominant Retinitis Pigmentosa

Inherited retinal degenerations (IRD) are a leading cause of visual impairment and can result from mutations in any one of a multitude of genes. Mutations in the light-sensing protein rhodopsin (RHO) is a leading cause of IRD with the most common of those being a missense mutation that results in substitution of proline-23 with histidine. This variant, also known as P23H-RHO, results in rhodopsin misfolding, initiation of endoplasmic reticulum stress, the unfolded protein response, and activation of cell death pathways. In this study, we investigate the effect of α-crystallins on photoreceptor survival in a mouse model of IRD secondary to P23H-RHO. We find that knockout of either αA- or αB-crystallin results in increased intraretinal inflammation, activation of apoptosis and necroptosis, and photoreceptor death. Our data suggest an important role for the ⍺-crystallins in regulating photoreceptor survival in the P23H-RHO mouse model of IRD.     

永磁同步电机模型预测转矩控制客观评价法综述

由于永磁同步电机模型预测转矩控制的控制目标量纲不同,其成本函数需加权求和,但权重系数的设计与调节较为困难。将模糊决策法、VIKOR法、TOPSIS法、变异系数赋权法和熵值赋权法等客观评价法应用于永磁同步电机模型预测转矩控制以解决上述问题。对于仅考虑磁链和转矩控制的永磁同步电机模型预测转矩控制,上述方法均是可行的,无需权重系数,但在一定程度上增加了计算负担。不同策略的控制性能存在一定的差异,但整体基本相当。由综合性能对比可知,TOPSIS法的控制性能相对最优。     

图像特征抽取的奇异值分解方法

传统的PCA方法和LDA方法扯处理图像识别问题时,一般先将图像矩阵转化为图像向量,然后以该图像向量作为原始特征进行特征抽取。近来一些研究人员提出利用图像矩阡瓿接构造敞布矩阵,并存此基础上进行特征抽取的方法。该文在该思想的基础上,提出了IMSVD方法。该方法没有采用PCA或LDA方法,而是利用奇肄值分解方法进行特征抽取。对ORL人脸阁像的识别试验结果表明,IMSVD订法具有良好的特征抽取性能。     

Controllable layer-by-layer assembly based on brucite and alginates with the assistance of spray drying and flame retardancy influenced by gradients of alginates

With the aim of tailoring and controlling surface assembly, multifunctional flame retardants (FRs) were obtained based on depositing alginates and silane coupling agents on brucite via the spray-drying-assisted layer-by-layer assembly technique. The assembly was controllable in both structure and gradient mass. Two series of FRs were named CuFR1-3 and NiFR1-3 based on the assembly content of metal alginates. With the assistance of spray drying, good compatibility between FRs and ethylene-vinyl acetate (EVA) was obtained, resulting in better mechanical properties. Meanwhile, the FRs improved flame retardancy and smoke suppression when used in EVA composites. With 55 wt % loading, composites with CuFR3 and NiFR1 passed UL 94 V-0 rating, while those with brucite were not rated. The peak of heat release rate decreased by 51.7 and 49.3% while the residue increased by 9.8 and 11.9%, respectively. The FRs also reduced the smoke and CO production rates. For the two series of FRs, the relationship between FR efficiency and alginate contents is different. The CuFRs assembled more copper alginates and exerted better flame retardancy caused by lower catalytic graphitization. NiFRs exerted a higher catalyzing efficiency at low assembly content. However, at high assembly content, the catalytic graphitization effect would decrease by thermally oxidized degradation leading to excess nickel alginates. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 47570.     

山东某原生金矿石可选性试验研究

对山东某原生金矿石进行了可浮性试验研究。通过对浮选指标各影响因素的优化.得出了粗选的最佳操作条件:磨矿细度-74μm 60%;活化剂CuSO_4150g/t;复合捕收剂LD-1 100g/t;起泡剂11号油20 g/t。在此条件下进行一次粗选、两次精选、两次扫选实验室闭路试验,可获得金精矿品位为73.46g/t、回收率为95.29%的较好指标,表明该原生金矿可以通过浮选达到顶先富集的目的。     

老挝某金矿工艺矿物特性与其全泥氰化提金工艺相关性分析

对老挝某金矿进行工艺矿物学研究,通过化学分析、金物相分析、光学显微镜、扫描电镜等手段,查明了金在矿石中的赋存状态、嵌布特征、金矿物形貌、游离金在矿石中的分配等特征,基于此研究制定了全泥氰化提金工艺流程,并得到后续选矿工艺试验验证,可更好指导矿山现场生产,为东南亚地区类似金矿回收提供经验及理论依据。     

新疆某伴生铜钴矿降砷回收工艺研究

对新疆某含砷低品位铜钴矿进行了降砷选矿工艺试验研究,并对伴生钴进行了富集回收探索研究。通过流程及浮选药剂条件试验,确定在-74μm 80%的磨矿细度条件下,采用优先浮选铜、抑制剂抑砷、尾矿回收伴生钴工艺,得到了铜品位24.29%、铜回收率83.16%、As品位低于3‰的铜精矿产品,得到钴品位4.72‰、回收率58.04%的钴硫精矿产品。     

共晶Ga—In合金的液态结构与粘度研究

利用液态金属X射线衍射仪测试了室温下Ga-24.6%In共晶合金的强度曲线、结构因子、双体分布函数以及原子间最近邻距离。结果表明,液态共晶Ga-In合金结构因子的第一峰呈明显的不对称。表明熔体中仍保留有部分Ga的共价键。,建立了共晶Ga-In合金的结构模型。利用此模型计算所得结果与用Gauss分解所得结果吻合良好;利用回转振动粘度仪进行了粘度测量。结果表明,共晶Ga-In合金的粘度值在100－600℃范围内满足指数关系,表明熔体中没有发生结构转变。并给出了其粘度与温度的关系式。