Acetazolamide challenge and technetium-99m-ECD versus iodine-123-IMP SPECT in chronic occlusive cerebrovascular disease

We compared the acetazolamide challenge test using 99mTc-ECD SPECT and 123I-IMP SPECT images in patients with chronic occlusive cerebrovascular disease. We also evaluated the usefulness of linearization correction for acetazolamide challenge test of 99mTc-ECD SPECT. METHODS: Twenty patients with unilateral chronic occlusive cerebrovascular disease (10 patients had middle cerebral arterial lesion and 10 had internal carotid lesion) were included in the study. Split-dose (a dose fractioning was 1:2), and sequential SPECT technique was used for 99mTc-ECD SPECT studies while only acetazolamide challenge test studies for 123I-IMP SPECT were performed. Permeability surface area product model (PS model) and back-diffusion model (Lassen's correction) were used for linearization correction of acetazolamide challenge with 99mTc-ECD SPECT. RESULTS: Six of 16 patients with reduced vasodilatory capacity in 123I-IMP SPECT were underestimated by 99mTc-ECD SPECT acetazolamide challenge test. Relative ECD uptake normalized by cerebellar uptake compared with IMP uptake showed a nonlinear relationship, indicating relatively less uptake in high flow range. The underestimations of limited vasodilatory capacity observed in 99mTc-ECD SPECT without linearization correction was modified by linearization algorithm. However, the effect of correction based on PS model was superior than that of Lassen's correction. The corrected 99mTc-ECD uptake ratio, based on PS model, and IMP uptake ratio demonstrated a better linear relationship than that of Lassen's correction. CONCLUSION: Technetium-99m ECD SPECT corrected based on the PS model is a better method of linearization for evaluating cerebrovascular reserve using acetazolamide challenge.     

Implementation of secure digital communication by hyperchaoticsynchronisation

By active-passive-decomposition synchronisation, the application of the one-way coupled ring map lattice hyperchaotic system in secure digital speech communication is demonstrated. Synchronisation guarantees strong security and recovery without error     

光纤压力传感器微机控制与数据处理系统

本文介绍的光纤压力传感器微机控制与数据处理系统是以8098单片机为核心,配上适量的外围电路所构成。该系统直接利用8098单片机芯片内的A/D模拟输入通道和脉宽调制(PWM)功能来进行数据采集和输出控制信号。该系统还方便地实现与微型打印机的联接,以便将采集的数据保存。整个系统结构简单,成本低,可靠性高,实时控制和测试功能较强,有良好的工业应用价值。     

铁钴钒软磁合金损耗谱的分形结构

研究了铁钴钒软磁合金的铁芯损耗，发现铁芯损耗谱具有分形结构。讨论了带材厚度和磁感应强度对分形维数Ｄｆ的影响。     

Measurements ofPVTx properties of refrigerant mixture HFC-32+HFC-125 in the gaseous phase

The experimental 156PVTx properties of an important binary refrigerant mixture, HFC-32 (difluoromethane)+HFC-125 (pentafluorethane), have been measured for three compositions, i.e., 50, 60, and 80 wt% HFC-32, by a constant-mass-method coupled with expansion procedure in an extensive range of temperaturesT from 320 to 440 K, of pressuresP from 1.8 to 5.3 M Pa, and of densities p from 50 to 124 kg · m^–3. The experimental uncertainties of the present measurements are estimated to be within ±7 mK in temperature, ±2 kPa in pressure, ±0.2% in density and ±0.02 wt% of HFC-32. The sample purities are 99.998 wt% for HFC-32 and 99.99 wt% for HFC-125. Seventy-eight second and third virial coeflicients for temperatures from 320 to 440 K have been determined by the present measurements.Paper presented at the Twelfth Symposium on Thermophysical Properties, June 19–24, 1994, Boulder, Colorado, U.S.A.     

Hematopoietic and lymphopoietic responses in human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor transgenic mice injected with human GM-CSF

Using a clonal assay of bone marrow (BM) cells from transgenic mice (Tg-mice) expressing the human granulocyte-macrophage colony-stimulating factor receptor (hGM-CSFR), we found in earlier studies that hGM-CSF alone supported the development not only of granulocyte-macrophage colonies, but also of erythrocytes, megakaryocytes, mast cells, blast cells, and mixed hematopoietic colonies. In this report, we evaluated the in vivo effects of hGM-CSF on hematopoietic and lymphopoietic responses in the hGM-CSFR Tg-mice. Administration of this factor to Tg-mice resulted in dose-dependent increases in numbers of reticulocytes and white blood cells (WBCs) in the peripheral blood. Morphological analysis of WBCs showed that the numbers of all types of the cell, including neutrophils, eosinophils, monocytes, and lymphocytes increased; the most remarkable being in lymphocytes that contained a number of large granular lymphocytes (LGLs) in addition to mature T and B cells. However, total cellularity of the BM of the Tg-mice decreased in a dose-dependent manner when hGM-CSF was injected. In sharp contrast to the BM, spleens of the Tg-mice were grossly enlarged. Although all types of blood cells and hematopoietic progenitors increased in the spleen, erythroid cells and their progenitors showed the most significant increase. Increased numbers of megakaryocytes and LGLs were also observed in spleen and liver of the treated Tg-mice. Flow cytometric analysis showed that LGLs expanded in Tg-mice expressed Mac-1+ CD3- NK1.1+. The thymus of Tg-mice treated with hGM-CSF exhibited a dose-dependent shrinkage and a remarkable decrease in CD4+ CD8+ cells. Thus, hGM-CSF stimulated not only myelopoiesis but also erythropoiesis and megakaryopoiesis of hGM-CSFR Tg-mice in vivo, in accordance with our reported in vitro findings. In addition, hGM-CSF affected the development of lymphoid cells, including natural killer cells of these Tg-mice.     

拉索_网壳结构的动力特性和非线性动力反应

将空间网壳结构与拉索有机结合便形成拉索-网壳结构体系。该体系不但具有美学特征，更可进一步增大跨度。基于泰勒数学展开公式和变分原理，推导了具有二阶精度的空间杆单元几何非线性刚度矩阵；研究了拉索单元非线性问题，得出了其切线刚度矩阵；给出了结构非线性力学响应计算策略等。通过数值计算，分析了结构动力特性和非线性地震动力响应问题。计算结果显示，拉索-网壳结构的自振频率皆明显高于对应的网壳结构，且频谱较为密集，甚至不同序号的自振频率几乎相同，拉索-网壳结构的地震动力响应不但与拉索长度、截面尺寸、预拉力和布置方式有关，还与塔柱高度、截面尺寸等有关。     

球罐活性缺陷的模糊评定方法

根据国内外有关标准和文献,利用模糊数学中的模糊描述和隶属度等概念,首次采用多级模糊综合评定理论,分层次地把活性缺陷的主要监测信息(即声发射源信息)和专家们的经验考虑在内,建立在用球形贮罐声发射源严重度多级模糊综合评定模型和方法,并编制计算机数据分析和处理程序,使评定结果趋于更合理和可靠.并给出在用球形贮罐声发射源严重度多级模糊综合评定算例,结果表明,该评定方法可以达到定量化的程度,与局部无损复验结果有良好的一致性.     

驱动压电陶瓷的高压放大器

概述了高压放大器的基本组成，以及采用高压稳压电源措施，提高高压放大器的性能，并简述了高压放大器输出级的工作原理，给出了过渡保护方法。     

Pharmacological study on circadian rhythms in mammals

Living organisms including humans drive circadian rhythm, and this rhythm influences the social structure and daily life of human beings. The suprachiasmatic nucleus (SCN) has been established as a pacemaker for mammalian circadian rhythm. There are many kinds of neurotransmitters and neuromodulators in this nucleus. The circadian systems are involved in oscillation, input (entrainment) and output (overt rhythm). Therefore in this review, pharmacological characteristics of circadian systems in relation to the SCN are discussed by focussing especially upon the roles of various neurotransmitters and modulators.