全文获取类型
收费全文 | 5344篇 |
免费 | 368篇 |
国内免费 | 34篇 |
学科分类
医药卫生 | 5746篇 |
出版年
2024年 | 10篇 |
2023年 | 58篇 |
2022年 | 169篇 |
2021年 | 259篇 |
2020年 | 147篇 |
2019年 | 218篇 |
2018年 | 228篇 |
2017年 | 141篇 |
2016年 | 199篇 |
2015年 | 222篇 |
2014年 | 269篇 |
2013年 | 332篇 |
2012年 | 509篇 |
2011年 | 463篇 |
2010年 | 261篇 |
2009年 | 212篇 |
2008年 | 311篇 |
2007年 | 313篇 |
2006年 | 330篇 |
2005年 | 240篇 |
2004年 | 253篇 |
2003年 | 203篇 |
2002年 | 170篇 |
2001年 | 21篇 |
2000年 | 10篇 |
1999年 | 31篇 |
1998年 | 39篇 |
1997年 | 22篇 |
1996年 | 22篇 |
1995年 | 16篇 |
1994年 | 12篇 |
1993年 | 11篇 |
1992年 | 8篇 |
1991年 | 2篇 |
1990年 | 6篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 7篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1943年 | 1篇 |
1921年 | 1篇 |
排序方式: 共有5746条查询结果,搜索用时 15 毫秒
101.
102.
Deqiang Duanmu Charles Bachy Sebastian Sudek Chee-Hong Wong Valeria Jiménez Nathan C. Rockwell Shelley S. Martin Chew Yee Ngan Emily N. Reistetter Marijke J. van Baren Dana C. Price Chia-Lin Wei Adrian Reyes-Prieto J. Clark Lagarias Alexandra Z. Worden 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(44):15827-15832
103.
Younghee Kim Valeria Tarallo Nagaraj Kerur Tetsuhiro Yasuma Bradley D. Gelfand Ana Bastos-Carvalho Yoshio Hirano Reo Yasuma Takeshi Mizutani Benjamin J. Fowler Shengjian Li Hiroki Kaneko Sasha Bogdanovich Balamurali K. Ambati David R. Hinton William W. Hauswirth Razqallah Hakem Charles Wright Jayakrishna Ambati 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(45):16082-16087
104.
Giuseppe Limongelli Teo Roselli Giuseppe Pacileo Paolo Calabró Valeria Maddaloni Daniele Masarone Lucia Riegler Rita Gravino Raffaella Scarafile Gemma Salerno Tiziana Miele Antonello D’Andrea Lucio Santangelo Massimo Romano Giovanni Di Salvo Maria Giovanna Russo Raffaele Calabró 《Internal and emergency medicine》2014,9(1):43-50
Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines. Plasma CT-1 levels correlate with the left ventricle mass index in patients with dilatated cardiomyopathy and congestive heart failure (CHF). The aim of this paper was to evaluate CT-1 plasma levels, before and after cardiac resynchronization therapy CRT, and to characterizeits prognostic role in patients with CHF. Fifty-two consecutive patients (M/F = 39/13; 56 ± 11 years old) underwent clinical and echocardiographic evaluation, and blood sample collection at baseline. The same evaluation was repeated 6.4 ± 0.79 months after CRT. Patients with a decreased LV end-systolic volume by at least 15% (reverse remodeling) were considered echo responders to CRT. Twenty-nine patients (56%) were responders to CRT. After CRT, only 15 patients (29%) showed increased CT-1 after CRT. They were all non responders to CRT. A multivariate, logistic modelshowed CT-1 as an independent predictor of CRT echo response (p = 0.005; OR 0.97). During follow-up (18 ± 7 months), 21 cardiac events in 18 patients occurred. A Cox multivariable model showed plasma BNP pre-CRT (p = 0.02; CI 1.2–5.6; OR 3.1) and CT1 post-CRT (p = 0.01; CI 1.4–4.3; OR 2.7) as independent predictors of cardiac events. Analysis of CT-1 plasma levels deserves future consideration for larger, longitudinal studies in patients with CHF. 相似文献
105.
106.
Gazzola V Spezio ML Etzel JA Castelli F Adolphs R Keysers C 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(25):E1657-E1666
Another person's caress is one of the most powerful of all emotional social signals. How much the primary somatosensory cortices (SIs) participate in processing the pleasantness of such social touch remains unclear. Although ample empirical evidence supports the role of the insula in affective processing of touch, here we argue that SI might be more involved in affective processing than previously thought by showing that the response in SI to a sensual caress is modified by the perceived sex of the caresser. In a functional MRI study, we manipulated the perceived affective quality of a caress independently of the sensory properties at the skin: heterosexual males believed they were sensually caressed by either a man or woman, although the caress was in fact invariantly delivered by a female blind to condition type. Independent analyses showed that SI encoded, and was modulated by, the visual sex of the caress, and that this effect is unlikely to originate from the insula. This suggests that current models may underestimate the role played by SI in the affective processing of social touch. 相似文献
107.
Giordano C Viscomi C Orlandi M Papoff P Spalice A Burlina A Di Meo I Tiranti V Leuzzi V d'Amati G Zeviani M 《Journal of inherited metabolic disease》2012,35(3):451-458
Ethylmalonic encephalopathy (EE) is a rare autosomal recessive disorder characterized by early onset encephalopathy, chronic diarrhoea, petechiae, orthostatic acrocyanosis and defective cytochrome c oxidase (COX) in muscle and brain. High levels of lactic, ethylmalonic and methylsuccinic acids are detected in body fluids. EE is caused by mutations in ETHE1, a mitochondrial sulphur dioxygenase. By studying a suitable mouse model, we found that loss of ETHE1 leads to accumulation of sulphide, which is a poison for COX and other enzymatic activities thus accounting for the main features of EE. We report here the first autopsy case of a child with a genetically confirmed diagnosis of EE, and compare the histological, histochemical and immunohistochemical findings with those of the constitutive Ethe1 (-/-) mice. In addition to COX depleted cells, widespread endothelial lesions of arterioles and capillaries of the brain and gastrointestinal tract were the pathologic hallmarks in both organisms. Our findings of diffuse vascular damage of target critical organs are in keeping with the hypothesis that the pathologic effects of ETHE1 deficiency may stem from high levels of circulating hydrogen sulphide rather than the inability of specific organs to detoxify its endogenous production. 相似文献
108.
Manetti M Allanore Y Saad M Fatini C Cohignac V Guiducci S Romano E Airó P Caramaschi P Tinazzi I Riccieri V Della Rossa A Abbate R Caporali R Cuomo G Valesini G Dieudé P Hachulla E Cracowski JL Tiev K Letenneur L Amouyel P Lambert JC Chiocchia G Martinez M Ibba-Manneschi L Matucci-Cerinic M 《Annals of the rheumatic diseases》2012,71(6):1034-1041
109.
110.
Chiarella Sforza Alice Frigerio Andrea Mapelli Filippo Mandelli Fernanda V. Sidequersky Valeria Colombo Virgilio F. Ferrario Federico Biglioli 《Journal of cranio-maxillo-facial surgery》2012,40(5):473-479
To quantify the effects of facial palsy reanimation, 14 patients aged 17–66 years were analysed. All patients had unilateral facial paralysis, and were candidates for surgical masseteric to facial nerve anastomosis. Two patient groups were measured: seven patients were waiting for surgery, the other seven patients had already been submitted to surgery, and had regained facial mimicry. Each patient performed three facial animations: brow raise; free smile; lip purse. These were recorded using an optoelectronic motion analyser.The three-dimensional coordinates of facial landmarks were obtained, their movements were computed, and asymmetry indices calculated (differential movements between the two hemi-faces: healthy and paretic/rehabilitated). Before surgery, mobility was larger in the healthy than in the paretic side; after surgery, the differences were reduced (brow raise and lip purse), or even reversed (smile). Before surgery, lip purse was performed with significant labial asymmetry (p = 0.042; larger healthy side movement). After surgery, asymmetry indices reduced. Total labial asymmetry during smiling was significantly different from 0 before surgery (p = 0.018, larger healthy side movement). After surgery, all asymmetry indices became non-significant. Before surgery the lateral displacements of all labial landmarks were towards the healthy side, while they normalized after surgery. 相似文献