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91.
To improve maternal-child services (MCH) services within existing health infrastructures, an operational project was initiated in district Ambala, Haryana, in northern India in February 1985. The main project strategies are training of primary health care (PHC) workers, logistic improvement, and monitoring. This paper reports on the 1st year of project operation and deals with the changes in availability of MCH care facilities. Before and after surveys were undertaken in a sample of 71 and 74 villages, respectively, across 3 blocks of the intervention area (population=370,000). 62 villages from 2 adjacent blocks (population=250,000) were also surveyed at the same time as the after survey; these served as concurrent controls. The information was collected from the village leaders and healthworkers by trained fieldworkers. The villages in intervention area registered a substantial improvement in availability of oral rehydration salts (from 0-67.5%), cotrimoxazole for treatment of acute respiratory infection (from 0-54%), contraceptives (from 34-65%), disposable safe birth kit (from 0-54%), scales for weight (from 24-53%), and health education material (from 0-46%) at the end of the 1st year of project operation. Although the developmental characteristics of the villages included in the after survey and in the concurrent control group did not differ significantly, there was a 2-4 fold increase in MCH facilities in the intervention area. A substantial improvement in MCH care facilities can be achieved in a short period of time even within the constraints of an existing health infrastructure through focused efforts in training and logistics improvement. 相似文献
92.
Spontaneous extrusion of a subconjunctival cysticercus cyst is a rare occurrence. The case reported is of a 20-year-old man who presented with a subconjunctival cysticercus cyst that was suspected to be undergoing spontaneous extrusion. The eye was photographed as the parasite extruded through the conjunctival opening with undulating movements over 3-4 min. 相似文献
93.
Georgieva R Tsevi R Kossev K Kusheva R Balgjiska M Petrova R Tenchova V Gitsov I Troev K 《Journal of medicinal chemistry》2002,45(26):5797-5801
The necessity to apply near-toxic amounts of radioprotective drugs to achieve adequate protection during radiation treatments represents a major problem in human medicine. One of the promising strategies to suppress the toxicity of these drugs involves their incorporation into biocompatible polymers. In this study cysteamine (Cy) was attached to poly(oxyethylene phosphate), POEP, via an ionic bond. Radioprotection of E. coli B cells by this substance and its acute toxicity on male C57 BL mice were measured. The toxicity of Cy immobilized within the poly(oxyethylene phosphate) was significantly lower in comparison to pure Cy while its radioprotective efficiency remained high at half the maximum tolerable dose. The high radioprotective efficiency of the Cy/POEP complexes was further confirmed on mice at different polymer molecular weight characteristics, drug immobilization degrees, application times, and doses. It was found that POEP with molecular weight 4700 Da and containing 24% repeating units with attached Cy has the highest protection potential combined with a depot effect. 相似文献
94.
Kennes J Rosenbaum P Hanna SE Walter S Russell D Raina P Bartlett D Galuppi B 《Developmental medicine and child neurology》2002,44(4):240-247
In this study parents' systematic accounts of the health status of 408 school-aged children with cerebral palsy (CP) are reported (221 males, 187 females; mean age 8 years 5 months, SD 1 year 11 months; range 5 to 13 years), as are relations between severity of functional motor impairment and eight functional health status domains. Data were collected as part of a longitudinal study of the motor development of a population-based, stratified, random sample of children with CP from across Ontario, Canada. The Gross Motor Function Classification System (GMFCS) was used to classify severity of CP and functional health status was described with the eight-level Health Utilities Index-Mark 3. Rates of functional limitations in Mobility, Dexterity, Speech, and Vision were statistically significantly associated with GMFCS levels (all p<0.01), with correlation values (tau-b) of 0.82, 0.58, 0.46, and 0.36, respectively. Functional limitations in hearing (tau-b=0.16; p=0.04) and cognition (tau-b=0.27; p<0.01) were both statistically significantly associated with GMFCS levels, though correlations were low. Neither emotion (tau-b=0.03; p=0.24) nor pain (tau-b=0.07; p=0.37) was associated with degree of functional limitation as described by the GMFCS. Clinical and epidemiological implications of findings are discussed. 相似文献
95.
96.
JR Bapuraj V Ojili SK Singh GRV Prasad N Khandelwal S Suri 《Journal of Medical Imaging and Radiation Oncology》2006,50(2):179-182
Leiomyoma of the vagina is a very rare tumour of the lower urogenital tract. These slow‐growing masses may be asymptomatic or present with pain, dyspareunia or urinary symptoms. Rarely, these tumours may present with life‐threatening haemorrhage. These hypervascular tumours are treated by surgical excision. Preoperative embolization therefore may aid in devascularization of these tumours before surgical excision. We present the MRI features of a case of vaginal leiomyoma, which was managed by preoperative embolization and was then excised in toto. To the best of our knowledge, this is the first report where preoperative embolization was performed before excision of a vaginal leiomyoma with minimal peroperative blood loss. 相似文献
97.
The adverse effects of thalidomide in relapsed and refractory patients of multiple myeloma. 总被引:1,自引:0,他引:1
Thalidomide has shown efficacy in relapsed or refractory patients of multiple myeloma (MM). We present the adverse effect profile of thalidomide in 23 relapsed or refractory MM patients treated with this drug over a period of 15 months. Constipation (100% incidence) and sedation (87%) were the most common adverse effects. Neuropathy had low incidence and was late in onset (>12 months). Tolerance developed to sedation, constipation and skin lesions. All the adverse drug reactions were tolerable and did not warrant decrease or termination of therapy, except for peripheral neuropathy. Contrary to Western reports, peripheral neuropathy in Indian patients developed at a cumulative dose of 200 g or more after 10 months or more of therapy. Therapy was discontinued in one patient due to marked elevation of liver enzyme that was later attributed to acute hepatitis C infection. Only one patient dropped out of the trial for unknown reasons. Overall, thalidomide was found to be a relatively safe drug that can be used over a prolonged period of time. 相似文献
98.
99.
Are child pedestrians at increased risk of injury on one-way compared to two-way streets? 总被引:2,自引:0,他引:2
Wazana A Rynard VL Raina P Krueger P Chambers LW 《Canadian journal of public health. Revue canadienne de santé publique》2000,91(3):201-206
OBJECTIVES: To compare child pedestrian injury rates on one-way versus two-way streets in Hamilton, and examine whether the characteristics of child pedestrian injuries differ across street types. METHODS: The rates of injury per child population, per kilometre, per year were calculated by age, sex and socio-economic status (SES). Child, environment and driver characteristics were investigated by street type. RESULTS: The injury rate was 2.5 times higher on one-way streets than on two-way streets and 3 times higher for children from the poorest neighbourhoods than for those from wealthier neighbourhoods. SES, injury severity, number of lanes, collision location and type of traffic control were also found to be significantly different across street types. CONCLUSIONS: One-way streets have higher rates of child pedestrian injuries than two-way streets in this community. Future risk factor and intervention studies should include the directionality of streets to further investigate its contribution to child pedestrian injuries. 相似文献
100.
RJ Gilbertson E Harris SK Pandey P Kelly W Myers 《Archives of disease in childhood》1996,75(3):194-198
Paracetamol is the commonest agent employed in self poisoning, however it is not clear whether adolescents possess insight into the serious complications associated with its misuse. Using a one page questionnaire, the availability, usage, and knowledge of toxicity of paracetamol among 1147 American and British adolescents was assessed. Although 90% of all students recognised that paracetamol could kill, the great majority of students overestimated the lethal dose. In addition, while knowledge regarding side effects of paracetamol was poor the drug was widely available to, and used by, the study population. It is proposed that gross overestimation of the number of tablets required to kill, poor understanding of paracetamol side effects, and wide availability of the drug contribute to its frequent use in adolescent suicidal behaviour. The inclusion of some over-the-counter medications in school drug education programs in addition to tighter control of the availability of paracetamol may help reduce the problem of adolescent self poisoning. 相似文献