全文获取类型
收费全文 | 431篇 |
免费 | 24篇 |
国内免费 | 4篇 |
学科分类
医药卫生 | 459篇 |
出版年
2022年 | 7篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 2篇 |
2018年 | 8篇 |
2017年 | 6篇 |
2016年 | 8篇 |
2015年 | 16篇 |
2014年 | 4篇 |
2013年 | 7篇 |
2012年 | 12篇 |
2011年 | 14篇 |
2010年 | 20篇 |
2009年 | 15篇 |
2008年 | 11篇 |
2007年 | 12篇 |
2006年 | 14篇 |
2005年 | 17篇 |
2004年 | 5篇 |
2003年 | 5篇 |
2002年 | 15篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 29篇 |
1997年 | 24篇 |
1996年 | 18篇 |
1995年 | 17篇 |
1994年 | 12篇 |
1993年 | 9篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 5篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 15篇 |
1986年 | 11篇 |
1985年 | 5篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 8篇 |
1969年 | 1篇 |
排序方式: 共有459条查询结果,搜索用时 15 毫秒
41.
A case of two secondary aneurysmal bone cysts arising in fibrous dysplasia during pregnancy is reported. Marked radiographic changes were seen in one lesion over a 3-week period. The development of these cysts during pregnancy strongly suggests that the hemodynamic and/or hormonal changes of pregnancy were responsible for their formation. 相似文献
42.
43.
44.
S M Jalal N R Schneider M K Kukolich G N Wilson 《American journal of medical genetics》1990,37(4):548-550
A heteromorphism of the short arm of 16 (16p+) was discovered in 2 unrelated infants. By G banding, the euchromatic variant appears as a light and a medium dark band just distal to the centromere. This results in an increase of the short arm by about 1/3. The same variant was present in the normal father and the normal paternal grandmother in one family and mildly retarded mother in the 2nd family. The anomalies of the 2 infants are not similar and are apparently unrelated to the 16p+ variant. Though the discovery of such euchromatic variants is highly significant for clinical diagnosis, their genetic significance and mode of origin remain to be elucidated. 相似文献
45.
Y Cottin JM Doise V Maupoil M Tannière-Zeller F Dalloz M Maynadié MK Walker P Louis PM Carli JE Wolf and L Rochette† 《Fundamental & clinical pharmacology》1998,12(2):236-241
Summary— Free radical species have been implicated as important agents involved in myocardial ischemic and reperfusion injuries. Superoxide is capable of mobilizing iron from ferritin and the released iron can cause hydroxyl formation from H2O2. The aim of this study was to evaluate the time-dependent increase in lipid peroxidation assessed by plasma thiobarbituric acid reactive substances (TBARS) and the relationship between lipid-peroxidation and the iron status. Peripheral venous blood samples were obtained from 17 men with acute myocardial infarction (AMI) before thrombolytic treatment (T0***) and 1, 2, 3, 4, 8, 12, 16, 20, 24 and 48 hours after commencing fibrinolytic treatment. The concentration of TBARS, the parameters of iron metabolism, serum myoglobin, creatine kinase, and creatine kinase-MB were measured. Early reperfusion was judged by regression of sinus tachycardia (ST) elevation and reduction of chest pain. Recanalization of coronary artery was evaluated by a late coronary angiography 24–96 hours after thrombolysis. After thrombolytic therapy, the TBARS level was raised from 2.98 ± 0.80 (T0***) to 4.57 ± 1.24 (peak), and decreased to 2.96 ± 0.40 nmol/mL plasma at T48 (T0 vs peak: P < 0.001, peak vs T48: P < 0.001, TO vs T48: NS). The mean time of the peak was observed at 9.7 ± 7.5 hours. The iron increased significantly from 0.67 ± 0.34 (T0) to 1.15 ± 0.52 mg/L (peak), and returned to the pre-reperfusion to levels: 0.53 ± 0.28 UI/L at T48 (T0 vs peak: P < 0.001, peak vs T48: P < 0.001, TO vs T48: NS). The mean time of the peak was observed at 9.4 ± 7.3 hours. In return, no correlation was found between the increase of plasma creatine-kinase activity, myoglobin and iron or between the biochemical markers and time of fibrinolytic therapy. The results confirmed the importance of the temporal relationship between lipid peroxidation and iron status after thrombolytic therapy. Our results are in agreement with the concept that antioxidant agents used in association with thrombolytic therapy might be useful. 相似文献
46.
Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells 总被引:5,自引:2,他引:5
Rill DR; Santana VM; Roberts WM; Nilson T; Bowman LC; Krance RA; Heslop HE; Moen RC; Ihle JN; Brenner MK 《Blood》1994,84(2):380-383
Patients with solid tumors are increasingly being treated by autologous bone marrow transplantation (BMT). Although response rates appear to be increased, disease recurrence is the commonest cause of treatment failure. Whether relapse is entirely due to residual disease in the patient or arises also from infiltrating malignant cells contained in the autologous marrow transplant has not been resolved. If the latter explanation is correct, then purging would be required as part of the transplantation procedure. We used retrovirally mediated transfer of the neomycin-resistance gene to mark BM harvested from eight patients with neuroblastoma in clinical remission. The marked marrow cells were subsequently reinfused as part of an autologous BMT. At relapse, we sought the marker gene in malignant cell populations. Three patients have relapsed, and in each the marker gene was detected by phenotypic and genetic analyses of resurgent malignant cells at medullary and extramedullary sites. Analysis of neuroblast DNA for discrete marker gene integration sites suggested that at least 200 malignant cells, each capable of tumor formation, were introduced with the autologous marrow transplant and contributed to relapse. Thus, autologous BMTs administered to patients with this solid tumor may contain a multiplicity of malignant cells that subsequently contribute to relapse. The marker-gene technique we describe should permit evaluation of the mechanisms of relapse and the efficacy of purging in patients receiving autologous marrow transplantation for other solid tumors that infiltrate the marrow. 相似文献
47.
48.
5-羟色胺对气道平滑肌细胞增生的影响及c-fos的表达 总被引:7,自引:0,他引:7
5-羟色胺对气道平滑肌细胞增生的影响及c-fos的表达刘振千梁凤珍马军红戚好文为了探讨哮喘气道平滑肌层增厚的机制,考察哮喘的炎性介质5-羟色胺(5-HT)对兔气道平滑肌细胞(ASMC)增生的影响及原癌基因c-fos的表达。新西兰大白兔,抗α-肌动蛋白... 相似文献
49.
50.