全文获取类型
收费全文 | 5961篇 |
免费 | 260篇 |
国内免费 | 22篇 |
学科分类
医药卫生 | 6243篇 |
出版年
2022年 | 29篇 |
2021年 | 77篇 |
2020年 | 41篇 |
2019年 | 73篇 |
2018年 | 71篇 |
2017年 | 74篇 |
2016年 | 79篇 |
2015年 | 89篇 |
2014年 | 128篇 |
2013年 | 161篇 |
2012年 | 238篇 |
2011年 | 260篇 |
2010年 | 156篇 |
2009年 | 135篇 |
2008年 | 228篇 |
2007年 | 285篇 |
2006年 | 296篇 |
2005年 | 291篇 |
2004年 | 244篇 |
2003年 | 257篇 |
2002年 | 224篇 |
2001年 | 234篇 |
2000年 | 212篇 |
1999年 | 198篇 |
1998年 | 82篇 |
1997年 | 76篇 |
1996年 | 65篇 |
1995年 | 46篇 |
1994年 | 45篇 |
1993年 | 60篇 |
1992年 | 172篇 |
1991年 | 167篇 |
1990年 | 156篇 |
1989年 | 163篇 |
1988年 | 117篇 |
1987年 | 137篇 |
1986年 | 96篇 |
1985年 | 88篇 |
1984年 | 76篇 |
1983年 | 75篇 |
1982年 | 35篇 |
1981年 | 34篇 |
1979年 | 59篇 |
1978年 | 47篇 |
1977年 | 39篇 |
1975年 | 29篇 |
1973年 | 28篇 |
1971年 | 27篇 |
1970年 | 33篇 |
1966年 | 27篇 |
排序方式: 共有6243条查询结果,搜索用时 15 毫秒
21.
Fusiform posterior cerebral artery aneurysm treated with excision and end-to-end anastomosis. Case report 总被引:2,自引:0,他引:2
A case of a ruptured fusiform aneurysm of the posterior cerebral artery is reported. The aneurysm was excised and end-to-end anastomosis was carried out between the two ends of the posterior cerebral artery. There is no previous report of a posterior cerebral artery aneurysm treated with this technique. The pertinent literature is reviewed and the significance of this technique in the treatment of unclippable cerebral aneurysms is discussed. 相似文献
22.
T Onitsuka T Yonezawa M Kuwabara K Nakamura H Sugimoto Y Tsuchida Y Fukushima Y Matsuzaki M Sakihama K Shibata 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(7):562-564
A 48-year-old woman was admitted to our hospital suffering from chest and back pain. The aortogram and CT scanning revealed aortic dissection (DeBakey II type). Six days after onset, the emergent operation was carried out under the cardio-pulmonary bypass. Myocardial protection was made by retrograde coronary sinus perfusion (RCSP) with cold GIK. The ascending aorta was replaced with an artificial graft including the entry. Massive bleeding in the pericardial space and the rupture of coronary sinus was recognized immediately after declamping of the aorta. Repair was made successfully under induced electric ventricular fibrillation. Care for RCSP was discussed. 相似文献
23.
Hirofumi Fukushima Emiko Katou Kouji Nagayama Akira Shirachi Michio Sata 《Nihon Shokakibyo Gakkai zasshi》2006,103(6):661-666
A 80-year old man was referred to our hospital because of an elevation of serum amylase level. Diffuse enlargement of the pancreas was detected by abdominal computed tomography, and also diffuse narrowing of the main pancreatic duct was revealed using endoscopic retrograde cholangiopancreatography. The serum level of IgG was elevated to 3450mg/dl. Besides, on the 10th hospital day, petechia developed and the platelet level decreased to 1.5 x 10(4)/microl. The platelet-associated IgG, antiplatelet antibody and antinuclear antibody in serum were positive. The levels of serum complements were low. From all these findings the patient was diagnosed as autoimmune pancreatitis complicated with immune thrombocytopenia. The treatment with prednisolone was started, which was effective on each disease. The medication was suspended a year ago, and so far there is no data suggesting the recurrence of autoimmune pancreatitis or immune thrombocytopenia. 相似文献
24.
25.
H Tokimura K Todoroki T Asakura M Atsuchi T Fukushima 《Neurologia medico-chirurgica》1992,32(5):292-295
A rare case of extracranial internal carotid artery (ICA) aneurysm coexisting with intracranial multiple aneurysms in a 64-year-old female is reported. The three intracranial aneurysms were clipped uneventfully by two-stage craniotomies. The extracranial ICA aneurysm at the infratemporal region was excised through a high cervical route and ICA was reconstructed by an end-to-end direct anastomosis. Ours is the first case reported of extra- and intracranial aneurysms surgically treated successfully. 相似文献
26.
Y Misawa T Hasegawa K Fukushima Y Sohara M Katoh F Murayama N Hasegawa H Horimi T Saitoh T Yamaguchi 《[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai》1992,40(7):1085-1088
Following cardiac surgery, approximation of sternum will produce systemic hypotension or elevation of left atrial and central venous pressures. A new criteria for delayed sternal closure is proposed. Sternal closure has to be delayed when mean left atrial or central venous pressures increased over 2 mmHg at the tentative closure. In seven cases (3.5%) of consecutive 201 patients was delayed the sternal closure under the above mentioned state, all survived and received the successful closure later. One of them died of congestive heart failure four months after the operation and one died of the rupture of the ascending aortic pseudoaneurysm eleven months after the initial operation. Microbiological examination of the mediastinal and pericardial contents obtained at the final sternal closure were negative in all cases. Comparing the total cardiopulmonary bypass time, ventricular fibrillation time, and myocardial ischemic time between in the secondary closure group and in the primary closure group, the total bypass time and the ventricular fibrillation time of the former were significantly longer than the latter, but the ischemic time revealed no difference. In conclusions, persistent elevation of left atrial or central venous pressures after cardiac surgery at the tentative sternal closure seems the reliable predictor for the delayed closure of the sternum. Careful post-operative management prevents serious mediastinal infection. Delayed sternal closure is preferable procedure for the patient with brittle hemodynamics after open heart surgery. 相似文献
27.
Yuki Mawatari Akira Hirata Mikiko Fukushima Hidenobu Tanihara 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(8):1056-1059
Purpose To evaluate quantitative choroidal dye filling velocity in patients with Vogt-Koyanagi-Harada disease (VKH) before and after corticosteroid treatment using indocyanine green (ICG) angiography.Methods ICG angiography was performed in seven VKH patients before and after systemic corticosteroid treatment. Choroidal dye curves were obtained by image analysis software and analyzed using an exponential model. The model’s time constant (τ) was used to evaluate choroidal dye filling velocity.Results Compared with controls, acute phase choroidal τ values in VKH patients were significantly longer, suggesting choroidal circulation disturbance. During the recovery phase, choroidal τ values were significantly shortened, suggesting choroidal circulatory disturbance improvement.Conclusion Choroidal dye filling velocity may be useful for VKH diagnosis and verification of corticosteroid treatment effectiveness. 相似文献
28.
Koichi Tanaka Kazue Ozawa Satoshi Teramukai Yasutsugu Takada Hiroto Egawa Satoshi Kaihara Yasuhiro Fujimoto Yasuhiro Ogura Mureo Kasahara Masako Ono Hiroshi Sato Kenji Takai Masanori Fukushima Nagahiro Minato 《Liver transplantation》2006,12(5):792-800
The primed status of T cells is markedly different among liver transplant recipients, due to a lifetime of antigen exposure and reduced thymopoiesis by aging, and diseases. This study aims to characterize the preoperative immunological status of CD8+ T cell subpopulations and relate it to the outcome for liver transplant recipients. We classified 112 liver transplant recipients into 5 groups, based on hierarchical clustering of the CD8+CD45 isoform proportion of T cells. In Groups I and II (pediatric), the naive T cell proportion was more than 50%. In adult recipients, Group III was characterized by a naive T cell proportion of 50%, Group IV had the greatest effector/memory T cells (EM), and Group V had the greatest proportion of effector T cells. In Groups IV and V, the effector T cell proportion was considerably higher, and was accompanied by marked downregulation of the CD27+CD28+ subsets and upregulation of interferon gamma (IFN)-gamma, tumor necrosis factor-alpha, and perforin expression. Group V recipients tended to be complicated postoperatively, with a significantly reduced survival rate (1 yr, 66.8%) and markedly reduced Eastern Cooperative Oncology Group performance status. 相似文献
29.
Sho Haneda M.D. Kouhei Fukushima M.D. Yuji Funayama M.D. Chikashi Shibata M.D. Ken-Ichi Takahashi M.D. Hitoshi Ogawa M.D. Munenori Nagao M.D. Kazuhiro Watanabe M.D. Iwao Sasaki M.D. 《Journal of gastrointestinal surgery》2006,10(7):1051-1059
Our previous studies demonstrated that sodium glucose cotransporter 1 (SGLT-1) was induced in the remnant ileum of total colectomized
rats via the action of factors other than hyperaldosteronism. The aim of the present study was to clarify whether fecal stream
is required for the enhancement of SGLT-1-mediated sodium transport. Twenty-seven pairs of ileal tissues were obtained from
the proximal and distal side, respectively, of loop ileostomy after total proctocolectomy. Mucosae were mounted in an Ussing
chamber to evaluate glucose-coupled sodium transport. Levels of SGLT-1 mRNA in proximal and distal mucosae were compared by
Northern blotting. Villous height and crypt depth were measured to test for correlations between mucosal structure and SGLT-1-mediated
sodium transport or mRNA expression levels. Both glucose-coupled sodium transport and expression of SGLT-1 mRNA were significantly
lower in distal mucosae relative to proximal mucosae. In distal mucosae, villous height, but not crypt depth, was significantly
lower than in proximal mucosae, demonstrating a positive correlation between villous height and SGLT-1 function and expression.
Comparative studies of proximal and distal mucosae demonstrated that in addition to hormonal changes, fecal stream is required
for full induction of the sodium transport system (which includes SGLT-1-mediated transport) in the remnant ileum following
total proctocolectomy.
Presented in part at the Forty-Sixth Annual Meeting of The Society for Surgery of the Alimentary Tract, Chicago, Illinois,
May 14–19, 2005 (poster presentation).
This work was supported by Grants-in-Aid for Scientific Research 10557118 and 14657295 from the Ministry of Education, Science
and Culture of Japan to K. Fukushima, and by Kanae Foundation to K. Fukushima. 相似文献
30.