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991.
992.
M Dakkak MD MRCP BP Jones MB ChB GP MGB Scott MB ChB MRCGP PJH Tooley MB BS MRCGP JR Bennett MD FRCP 《International journal of clinical practice》1994,48(1):10-14
SUMMARY Patients with endoscopically confirmed oesophagitis (n=49) were treated for 8 weeks with either cisapride (10 mg four times a day) or ranitidine (150 mg twice a day) in a double-blind study in general practice. Mean overall symptom scores fell from 10.8 to 4.5 in the cisapride group and from 9.9 to 4.4 in the ranitidine group over the course of the study. The proportion of patients reporting improvements in individual symptoms in the two treatment groups (cisapride and ranitidine respectively) were: heartburn, 66% and 55%; acid regurgitation, 53% and 47%; epigastric pain, 60% and 52%; satiety, 57% and 47%; bloating, 69% and 71%; belching, 65% and 72%; nausea, 62% and 85%; vomiting, 77% and 66%; poor appetite, 50% and 75%. Improvement in the endoscopic grade of oesophagitis was observed in 66% of patients receiving cisapride and 63% of those receiving ranitidine. It was concluded that cisapride is as effective as ranitidine in relieving the symptoms of oesophagitis and in healing oesophageal erosions. 相似文献
993.
Jens J. Froelich M.D. Christina Freymann Martin Hoppe Thomas Thiel H. Joachim Wagner Klemens H. Barth Klaus J. Klose 《Cardiovascular and interventional radiology》1996,19(6):423-427
Purpose Manual and automatic pulse-spray infusion techniques are compared in vitro to evaluate the efficacy of thrombolysis and the
distribution of urokinase and saline solution within thrombus using a pulse-spray catheter.
Methods A pulse-spray catheter was introduced into a human thrombus within a stenotic flow model. Automatic and manual pulsed infusion
of urokinase and automatic pulsed infusio of saline solution were compared. To quantify the efficacy of thrombolysis, pressure
gradients were recorded proximal and distal to the thrombus and during the course of infusion. Distribution of infused urokinase
was assessed radiographically.
Results The fastest and most homogeneous dissolution of the thrombus was achieved with automatic pulsed infusion of urokinase, shown
by decreasing transthrombotic pressure gradients (p<0.001, Wilcoxon, matched pairs). Manual pulsed infusion of urokinase or saline solution resulted in inhomogeneous thrombus
dissolution and delayed thrombolysis.
Conclusion Application of automatic pulse-spray injectors seems beneficial for more effective and homogeneous intraarterial pulse-spray
thrombolysis when compared with conventional manual pulsed technique. 相似文献
994.
OBJECTIVE: Prednisolone reduced the progression of joint destruction over 2
yr in early, active rheumatoid arthritis. The response to discontinuation
of prednisolone under double-blind conditions is now reported. METHODS: A
randomized, double-blind, placebo-controlled trial of prednisolone 7.5 mg
daily in addition to routine medication over 2 yr in 128 patients with
early rheumatoid arthritis, using radiological progression (changes in the
Larsen score) and the development of erosions as primary outcome measures.
Study medication was blindly discontinued and follow-up maintained for a
further year. Other assessments included disability, joint inflammation,
pain and the acute- phase response. RESULTS: Similar results were obtained
when all available radiographs were included for each year of assessment
(maximum 114) and when only patients with radiographs at all time points
were included (75 patients). In these 75, the mean progression in the
prednisolone group was 0.21 Larsen units in year 1, 0.04 units in year 2
and 1.01 units in year 3 (P = 0.587, 0.913 and 0.039 for change within each
year, respectively). The equivalent placebo group means were 2.34, 1.00 and
1.63 Larsen units (P = 0.001, 0.111 and 0.012; difference between groups:
2.13, 0.96 and 0.67 units, P = 0.082, 0.02 and 0.622). The percentage of
hands which had erosions at each time point was: prednisolone group: 27.8,
29.2, 34.7 and 39.2; placebo group: 28.2, 48.7, 59.0 and 66.5. There was
little evidence for a flare in clinical symptoms after discontinuation of
prednisolone. CONCLUSION: Joint destruction resumed after discontinuation
of prednisolone. This corroborates the previously reported therapeutic
effect and challenges current concepts of disease pathogenesis.
相似文献
995.
多抗甲素抗肿瘤转移作用及其机理 总被引:4,自引:0,他引:4
多抗甲素(PAA)在100mg·kg-1·d-1剂量下,给药18d,显著抑制B16-F10黑色素瘤人工肺转移,肺转移结节数由137个下降到95个。同位素参入法测定PAA对正常及荷瘤小鼠脾细胞有促增殖作用,并使小鼠脾细胞对PHA刺激的反应性不因荷瘤而降低;PAA且能增强正常及荷瘤小鼠脾脏NK细胞活性,拮抗环磷酰胺对NK细胞活性的抑制作用;PAA体外能不同程度地抑制B16-F10黑色素瘤细胞DNA,RNA和蛋白质合成。放射免疫测定法表明PAA对小鼠血浆TXA2/PGI2比值影响较小。PAA抗肿瘤转移作用主要与促进荷瘤机体抗肿瘤免疫反应和直接抑制肿瘤细胞有关。 相似文献
996.
An endoscopic technique for tubal anastomosis has been developed in a rat uterine horn model. Uterine segments were anastomosed endoscopically in a training device for surgical pelviscopy ('Pelvitrainer') by fibrin glue, using an inlaying splint as a guide. The anastomoses were accomplished by a seromuscular 6-0 suture at the anti-mesenteric border. Morphological studies revealed good patency of the anastomosed segments without stenoses or occlusions. The tissue continuity was good. In only two cases out of the 20 studied was a tapering of the uterine wall found adjacent to the anastomosis. It is concluded that this endoscopic technique for tubal anastomosis presents a useful alternative to classical microsurgical reversal of sterilization by laparotomy. 相似文献
997.
998.
999.
THOMAS G. WILSON JR. DDS FRANK L. HIGGINBOTTOM DDS † 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》1998,10(5):265-271
Abstract: Older adults present special problems for the dentist trying to establish or reestablish esthetics. Periodontal diseases are of concern for this population since tooth loss from these widespread problems increases with age. In general, this loss occurs because of increased exposure time to pathogenic bacteria, not some change inherent in the body brought on by the aging process. The profession has begun to place more emphasis on systemic risk factors and their role in modifying periodontal inflammation. The current thinking is that bacteria are necessary to initiate and sustain periodontal diseases, but the clinical manifestation is dictated to a significant extent by systemic factors. Smoking, diabetes, and being positive for the interleukin-1 genotype predispose the patient to developing more severe disease. For those older adults who lose teeth, dental implants have emerged as reliable replacements, and concerns about placing these devices in patients who have lost teeth as a result of periodontitis appear to be largely unfounded. 相似文献
1000.