156例晚期血吸虫病腹水常规与细胞学检查分析

晚期血吸虫病患者腹水多为漏出液，但由于各种细菌、病毒的感染与恶变，腹水的性质也随之发生变化，腹水性质的鉴定与细胞学检查十分重要。作者就荆州市血防所1996～2005年收治的晚期血吸虫病患者的腹水检查资料，进行回顾性分析。结果报告如下。     

胃食管反流病与功能磁共振技术

随着对胃食管反流病研究的深入,大脑和食管感觉及胃排空的相互作用越来越受到重视,功能磁共振成像技术,有助于进一步了解胃食管反流病的发病机制。     

Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury in rabbits.

There is very little evidence on the value of giving corticoids in cases of seawater drowning induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Therefore, this study aimed to investigate whether dexamethasone treatment can attenuate seawater instillation-induced acute lung injury in rabbits. Seawater (4 ml/kg body weight) was instilled into the lower trachea of ventilated, anesthetized rabbits. Then these rabbits were assigned randomly 20 min later to receive intravenous injection of 1mg/kg body weight of dexamethasone (dissolving in 2 ml of normal saline) or 2 ml of normal saline. All animals demonstrated immediate drops in arterial oxygen tension (PaO2) and the total thoracic compliance, which were significantly improved after 2 h of dexamethasone treatment. Histopathological study also indicated that dexamethasone treatment markedly attenuated lung histopathological changes, alveolar hemorrhage and inflammatory cells infiltration with evidence of decreasing of myeloperoxidase (MPO) activity and tumor necrosis factor-alpha (TNF-alpha) concentration in lung tissue. In addition, dexamethasone treatment reduced extravascular lung water and lung epithelial-endothelial barrier permeability, up-regulated the expression of surfactant protein-A (SP-A) and alpha-epithelial Na+ channel, and increased Na+/K+-adenosine triphosphatase (Na+/K+-ATPase) activity and Na+/K+-ATPase-alpha1 protein abundance. Thus, these data indicate that dexamethasone treatment might be of benefit in patients with seawater aspiration-induced ALI.     

拜唐苹治疗Ⅱ型糖尿病的临床观察及研究进展

目的观察拜唐苹治疗Ⅱ糖尿病的临床效果。方法30例病人，通过口服拜唐苹治疗一个月和一年后，记录血浆葡萄糖和血红蛋白，根据比较了解拜唐苹降糖效果。结果拜唐苹使患者的空腹血糖下降10．19％，非空腹血糖下降17．44％，血红蛋白治疗前有16人控制差，治疗后无一人控制差。结论拜唐苹治疗Ⅱ型糖尿病中空腹血糖轻中度增高，餐后血糖增高显著的病例，效果满意，副作用少。     

多巴胺或多巴胺复合去甲肾上腺素对肝移植术中患者血液动力学、氧代谢及肾功能的影响

目的评价原位肝脏移植术(OLT)中持续输注多巴胺或多巴胺复合去甲肾上腺素对血液动力学、组织氧代谢和肾功能的影响。方法拟行OLT的患者30例,ASAⅢ或Ⅳ级,随机分为2组 (n=15)。A组:术中持续输注多巴胺,初始输注速率为1-3μg·kg-1·min-1;B组:术中持续输注多巴胺复合去甲肾上腺素,初始输注速率分别为1-3μg·kg-1·min-1和0．03μg·kg-1·min-1,多巴胺输注速率不超过5μg·kg-1·min-1;术中两组均调节输注速率维持MAP 60-80 mm Hg。分别于切皮前即刻、切肝期1 h、无肝期1 h、新肝期1h和术毕测定血液动力学、组织代谢和肾功能指标。结果两组HR、 MAP均维持较平稳。无肝期两组CVP、MPAP、PAWP、CO、CI、DO2、VO2降低(P<0．05);SVR和SVRI升高(P<0．05),但均在正常范围内。术中PVR、PVRI、pH及SvO2均较平稳。乳酸浓度增高并持续到术毕。两组术中Cr和BUN均在正常范围,B组总尿量高于A组(P相似文献   

抑郁症患者血浆孤啡肽含量研究

目的为探讨抑郁症的可能病因,对抑郁症患者血浆孤啡肽(OFQ)含量进行了对照研究。方法抽取29例抑郁症患者和24例正常人的静脉血,用放射免疫(RIA)的方法分别测其血浆中OFQ含量,比较抑郁症患者和正常人血浆OFQ含量有无差异,抑郁症患者OFQ含量与汉密顿抑郁量表(HAMD)评分的相关性,及抑郁症患者血浆OFQ含量的影响因素。结果与正常人比较,抑郁症组OFQ含量明显升高(t=8．70,P＜0．0001)；OFQ含量与HAMD评分呈正相关(r=0．63,P＜0．01)；OFQ含量主要与抑郁情绪、夸大、失眠、自卑感、自杀、强迫症状、教育水平、关注身体健康等因素相关,而年龄、性别、职业、病程、曾用药等其他因素与OFQ含量无明显相关。结论通过测量血浆OFQ含量可作为抑郁症诊断的参考指标。     

正常人及脑肿瘤患者听觉性中英文语言刺激的fMRI研究

目的应用BOLD-MfRI研究正常人及脑肿瘤患者听觉性中英文语言皮层定位并探讨其对脑肿瘤的临床应用价值。方法应用MarconiEclipse1.5T超导型磁共振机,30例受试者,行听觉性中、英文语言刺激的BOLD-MfRI,以定位正常人和脑肿瘤患者的语言皮层。结果正常人听觉性中英文语言任务激活区域均以左侧大脑半球为主,主要有双侧颞横回、Wernicke区、Broca区和SMA区。中文语言任务刺激时脑区激活面积和程度比英文语言任务大,但英文语言任务时可见更明显的Broca区和角回激活。累及功能皮层的脑肿瘤患者患侧半球可见残留部分功能激活区,但激活区移位,分布弥散,激活程度及范围较正常人略增高。未累及功能皮层者功能区定位与正常人大致相同。结论BOLD-MfRI是一种有效而无创的功能皮层定位方法,有利于脑肿瘤的精确定位诊断并指导临床治疗。