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51.
Christian J. Sauder Cheryl X. Zhang Malen A. Link W. Paul Duprex Kathryn M. Carbone Steven A. Rubin 《Vaccine》2009
The recent global resurgence of mumps has drawn attention to the continued need for robust mumps immunization programs. Unfortunately, some vaccines derived from inadequately attenuated vaccine strains of mumps virus have caused meningitis in vaccinees, leading to withdrawal of certain vaccine strains from the market, public resistance to vaccination, or in some cases, cessation of national mumps vaccination programs. The most widely implicated mumps vaccine in cases of postvaccination meningitis is derived from the Urabe AM9 strain, which remains in use in some countries. The Urabe AM9 vaccine virus has been shown to exhibit a considerable degree of nucleotide and amino acid heterogeneity. Some studies have specifically implicated variants containing a lysine residue at amino acid position 335 in the hemagglutinin-neuraminidase (HN) protein with neurotoxicity, whereas a glutamic acid residue at this position was associated with attenuation. To test this hypothesis we generated two modified Urabe AM9 cDNA clones coding either for a lysine or a glutamic acid at position 335 in the HN gene. The two viruses were rescued by reverse genetics and characterized in vitro and in vivo. Both viruses exhibited similar growth kinetics in neuronal and non-neuronal cell lines and were of similar neurotoxicity when tested in rats, suggesting that amino acid 335 is not a crucial determinant of Urabe AM9 growth or neurovirulence. 相似文献
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Dr. jur. Hans Schneickert 《International journal of legal medicine》1941,34(4):404-411
Ohne Zusammenfassung 相似文献
55.
Hans Selye 《Canadian Medical Association journal》1949,61(6):553-556
56.
Hans v. Wyss 《Virchows Archiv : an international journal of pathology》1870,51(1):143-144
Ohne Zusammenfassung 相似文献
57.
Hans Otto 《Journal of molecular medicine (Berlin, Germany)》1940,19(23):562-565
Ohne Zusammenfassung 相似文献
58.
Axel Olsen T. Antoine Frommolt Theo Pütz Rudolf Koch Hans Heidler Kurt Walther Schultze H. A. Schmitz Elisabeth Koch Möhlmann Diethelm W. Janisch-Raschkowitsch Hansen Ostertag H. Dietel 《International journal of legal medicine》1943,37(3-4):197-206
Ohne Zusammenfassung 相似文献
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Peripheral quantitative computed tomography in children and adolescents: the 2007 ISCD Pediatric Official Positions 总被引:2,自引:0,他引:2
Babette Zemel Shona Bass Teresa Binkley Gaele Ducher Heather Macdonald Heather McKay Laurie Moyer-Mileur John Shepherd Bonny Specker Kate Ward Didier Hans 《Journal of clinical densitometry》2008,11(1):59-74
Peripheral quantitative computed tomography (pQCT) has mainly been used as a research tool in children. To evaluate the clinical utility of pQCT and formulate recommendations for its use in children, the International Society of Clinical Densitometry (ISCD) convened a task force to review the literature and propose areas of consensus and future research. The types of pQCT technology available, the clinical application of pQCT for bone health assessment in children, the important elements to be included in a pQCT report, and quality control monitoring techniques were evaluated. The review revealed a lack of standardization of pQCT techniques, and a paucity of data regarding differences between pQCT manufacturers, models and software versions and their impact in pediatric assessment. Measurement sites varied across studies. Adequate reference data, a critical element for interpretation of pQCT results, were entirely lacking, although some comparative data on healthy children were available. The elements of the pQCT clinical report and quality control procedures are similar to those recommended for dual-energy X-ray absorptiometry. Future research is needed to establish evidence-based criteria for the selection of the measurement site, scan acquisition and analysis parameters, and outcome measures. Reference data that sufficiently characterize the normal range of variability in the population also need to be established. 相似文献