全文获取类型
收费全文 | 1727篇 |
免费 | 103篇 |
国内免费 | 5篇 |
学科分类
医药卫生 | 1835篇 |
出版年
2023年 | 8篇 |
2022年 | 28篇 |
2021年 | 70篇 |
2020年 | 35篇 |
2019年 | 44篇 |
2018年 | 75篇 |
2017年 | 51篇 |
2016年 | 47篇 |
2015年 | 64篇 |
2014年 | 81篇 |
2013年 | 101篇 |
2012年 | 119篇 |
2011年 | 131篇 |
2010年 | 96篇 |
2009年 | 69篇 |
2008年 | 97篇 |
2007年 | 99篇 |
2006年 | 91篇 |
2005年 | 83篇 |
2004年 | 74篇 |
2003年 | 71篇 |
2002年 | 63篇 |
2001年 | 26篇 |
2000年 | 27篇 |
1999年 | 31篇 |
1998年 | 16篇 |
1997年 | 11篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 12篇 |
1991年 | 14篇 |
1990年 | 25篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 8篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有1835条查询结果,搜索用时 310 毫秒
991.
992.
993.
C.J. Presley Ling Han Linda Leo-Summers Arti Hurria Cary P. Gross Amy J. Davidoff Heather G. Allore Thomas M. Gill 《Journal of Geriatric Oncology》2019,10(1):60-67
Background
To characterize functional trajectories in the year before and after a new cancer diagnosis among older adults and to identify risk factors for worsening disability post-diagnosis.Methods
We identified 170 participants 70+ years with monthly assessments of thirteen basic, instrumental, and mobility activities and with a new cancer diagnosis from 1998 to 2014. A group-based trajectory model identified distinct functional trajectories based on a total disability score during the twelve months pre- and post-diagnosis. We evaluated associations between potential risk factors at the time of cancer diagnosis and worsening disability post-diagnosis, explored functional transitions from pre- to post-diagnosis and identified participants whose functional trajectories worsened.Results
Three pre-diagnosis functional trajectories were identified among 170 participants (mean age at diagnosis: 83?years (range: 73–105?years): mild, moderate, and severe disability. Three post-diagnosis functional trajectories were identified among 158 non-decedents: mild, moderate, and severe disability. Most participants (93.9%) with severe disability pre-diagnosis had severe disability post-diagnosis. Risk factors independently associated with worsening disability post-diagnosis included moderate or severe disability pre-diagnosis (adjusted risk ratio, aRR: moderate: 2.96; 95%CI: 2.11–4.16; severe: 5.11; 95%CI: 3.07–8.52) vs. mild (reference), poor physical capability (aRR: 1.57; 95%CI: 1.07–2.30), and incurable stage (aRR:1.99; 95%CI: 1.41–2.80). 40% of participants with a mild or moderate disability trajectory pre-diagnosis transitioned to a worse functional trajectory post-diagnosis.Conclusion
Older adults followed distinct functional trajectories in the twelve months before and after cancer diagnosis. Functional trajectory pre-diagnosis, poor physical capability, and incurable stage were independent risk factors for worsening disability post-diagnosis. 相似文献994.
995.
Incidence of perioperative visual loss ranges from 0.06% to 0.2% with the most common cause as ischemic optic neuropathy. We report one-year follow up of a 50-years-old hypertensive housewife who underwent lumbar decompression and fusion for degenerative scoliosis, but woke up with painless unilateral visual loss. Fundus examination was normal. Her visual acuity improved from initial finger counting close to face to finger counting at 3 m at 1 year. Identification of high risk patients may help in appropriate preoperative counselling, prevention and early recognition of this devastating complication. 相似文献
996.
Skin manifestations are prevalent in primary immunodeficiency disorders (PID). In a large proportion of patients, they manifest as presenting signs and serve as important factors for the early diagnosis of PID. Only a few studies describing the spectrum of skin disorders in PID are available. The objective of the current study was to determine the prevalence and characteristics of skin manifestations in children with PID. Participants were 128 pediatric patients with PID (aged <16 years) registered prospectively over 6 years. Skin manifestations were observed in 61 patients (48%), and those manifestations were the presenting features in 50 (39% of total PID and 82% of those with skin lesions). Skin infections were the most prevalent manifestations, seen in 39 patients (30%), followed by eczemas in 24 (19%). Skin infections were significantly more prevalent in those with congenital defects in phagocyte number, function, or both, as well as in those with well-defined immunodeficiencies. Although widely present in all participants with PID, eczema was a consistent feature (100%) in patients with hyper IgE syndrome and Wiskott-Aldrich syndrome (WAS). Erythroderma of infancy with diffuse alopecia was seen exclusively in patients with severe combined immunodeficiency disorders, telangiectasia in patients with ataxia telangiectasia, and partial albinism with silvery gray hair in those with Chediak-Higashi syndrome. Autoimmune skin manifestations were observed in 6% of reported cases of PID. This study highlights the importance of awareness of skin manifestations of PID to assist in the early diagnosis and management of these disorders. 相似文献
997.
Brandon D. L. Marshall Amaya G. Perez-Brumer Sarah MacCarthy Leandro Mena Philip A. Chan Caitlin Towey Nancy Barnett Sharon Parker Arti Barnes Lauren Brinkley-Rubinstein Jennifer S. Rose Amy S. Nunn 《AIDS and behavior》2016,20(6):1334-1342
The US HIV/AIDS epidemic is concentrated in the Deep South, yet factors contributing to HIV transmission are not fully understood. We examined relationships between substance use, sexual partnership characteristics, and condom non-use in an African American sample of STI clinic attendees in Jackson, Mississippi. We assessed condom non-use at last intercourse with up to three recent sexual partners reported by participants between January and June 2011. Participant- and partner-level correlates of condom non-use were examined using generalized estimating equations. The 1295 participants reported 2880 intercourse events, of which 1490 (51.7 %) involved condom non-use. Older age, lower educational attainment, reporting financial or material dependence on a sex partner, sex with a primary partner, and higher frequency of sex were associated with increased odds of condomless sex. HIV prevention efforts in the South should address underlying socioeconomic disparities and structural determinants that result in partner dependency and sexual risk behavior. 相似文献
998.
Kapil Dev Das Kaushik Ghosh Chinmoy Kar Ramesh Chandra Gharami Sisir Chakraborty Ambarish Bhattacharyya 《Indian journal of dermatology》2015,60(5):509-511
Spindle-cell hemangioendothelioma (SCHE) comprise a rare subset of vascular tumors, and here, we describe such a case and review the clinical presentation, patho-physiology, differential diagnosis of these tumors to promote early identification and discussion guidance. A 25-years-old male patient presented with multiple painful elevated swellings of both left upper and lower extremities for last 15 years without any systemic involvement. After excluding close differential diagnosis by relevant investigations an excisional biopsy was performed. Based on clinical, radiological and histopathological findings, diagnosis of SCHE was made and full thickness excision and skin grafting were performed. The case is reported due to its rarity and adds our knowledge to the existing literature. 相似文献
999.
Arun BK Dhinghra K Valero V Kau SW Broglio K Booser D Guerra L Yin G Walters R Sahin A Ibrahim N Buzdar AU Frye D Sneige N Strom E Ross M Theriault RL Vadhan-Raj S Hortobagyi GN 《The oncologist》2011,16(11):1527-1534
Objective.
To compare the pathologic complete response (pCR) rate of patients treated with 5-fluorouracil (5-FU), doxorubicin, and cyclophosphamide (FAC) versus dose-intense FAC plus G-CSF in the neoadjuvant setting and to compare the delivered dose intensity, disease-free survival (DFS) and overall survival (OS) times, and toxicity between treatment arms in patients with breast cancer.Methods.
Patients were randomized to receive preoperative FAC (5-FU, 500 mg/m2; doxorubicin, 50 mg/m2; cyclophosphamide, 500 mg/m2) every 21 days for four cycles or dose-intense FAC (5-FU, 600 mg/m2; doxorubicin, 60 mg/m2; cyclophosphamide, 1,000 mg/m2) plus G-CSF every 18 days for four cycles.Results.
Two hundred two patients were randomly assigned. The median follow-up was 7.5 years. Patients randomized to FAC plus G-CSF had a higher pCR rate as well as clinical complete response rate; however, these differences were not statistically different from those with the FAC arm. Patients in the FAC + G-CSF arm had a higher delivered dose intensity of doxorubicin in the neoadjuvant and adjuvant settings than those in the standard FAC arm. DFS and OS times were not significantly different between the two groups. However, the OS and DFS rates were significantly higher for patients who achieved a pCR than for those who did not. Thrombocytopenia, febrile neutropenia, and infection rates were higher in the FAC + G-CSF arm.Conclusions.
A higher delivered dose intensity of doxorubicin with the FAC + G-CSF regimen did not result in a statistically significant higher pCR rate. However, patients who achieved a pCR experienced longer DFS and OS times. 相似文献1000.
Jha P Suri V Jain A Sharma MC Pathak P Jha P Srivastava A Suri A Gupta D Chosdol K Chattopadhyay P Sarkar C 《Neurosurgery》2010,67(6):1681-1691