Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1s/sα2s/s Mouse Model of High Affinity for Cardiotonic Steroids

The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of cardiac conditions, CTS inhibit the ion-pumping function of Na/K-ATPase. At much lower concentrations, in the range of those reported for endogenous CTS in the blood, they stimulate hypertrophic growth of cultured cardiac myocytes through initiation of a Na/K-ATPase-mediated and reactive oxygen species (ROS)-dependent signaling. To examine a possible effect of endogenous concentrations of CTS on cardiac structure and function in vivo, we compared mice expressing the naturally resistant Na/K-ATPase α1 and age-matched mice genetically engineered to express a mutated Na/K-ATPase α1 with high affinity for CTS. In this model, total cardiac Na/K-ATPase activity, α1, α2, and β1 protein content remained unchanged, and the cardiac Na/K-ATPase dose–response curve to ouabain shifted to the left as expected. In males aged 3–6 months, increased α1 sensitivity to CTS resulted in a significant increase in cardiac carbonylated protein content, suggesting that ROS production was elevated. A moderate but significant increase of about 15% of the heart-weight-to-tibia-length ratio accompanied by an increase in the myocyte cross-sectional area was detected. Echocardiographic analyses did not reveal any change in cardiac function, and there was no fibrosis or re-expression of the fetal gene program. RNA sequencing analysis indicated that pathways related to energy metabolism were upregulated, while those related to extracellular matrix organization were downregulated. Consistent with a functional role of the latter, an angiotensin-II challenge that triggered fibrosis in the α1^r/rα2^s/s mouse failed to do so in the α1^s/sα2^s/s. Taken together, these results are indicative of a link between circulating CTS, Na/K-ATPase α1, ROS, and physiological cardiac hypertrophy in mice under baseline laboratory conditions.     

聚铝溶液pH值及盐基度的相关性研究

为聚铝溶液进行了ＰＨ值和盐基度的分析和估算,给出了聚铝溶液的极限ＰＨ值和极限盐基度与总溶解铝浓度的关系曲线,最终计算结果表明：在平衡条件下,聚铝溶液的ＰＨ值和盐基度具有相关性,即当基中一个参数发生变化时。另一个参数必然要发生相应的改变。     

电解液双效顺流蒸发工艺计算

对离子膜烧碱蒸发双效顺流工艺进行了计算,并通过计算对工艺参数相互之间的 关系做进一步探讨。     

青岗钾肥厂试车小结

为满足农业生产上对硫酸钾的需求，化工部上海化工研究院复肥所着重开发了硫铵转化法的生产工艺，并在推广过程中，针对操作工艺和设备上所存在的问题，继续探索，取得了新的结果。该技术已用于青岗钾肥厂万吨级硫酸钾生产装置。本文着重介绍了该装置在试车过程中所发生的问题及处理方法。     

智能高分子材料的研究进展

从合成及加工制造技术、新产品开发及其应用诸方面诸方面综述了智能高分子材料，如智能高分子凝胶、形状记忆高分子材料、智能织物、智能高分子膜、智能高分子复合材料等开发的新成果，并展望了其发展前景。     

临界组成区域的热敏导电材料加工工艺

研究了开炼，密炼及双螺杆挤出３种不同塑炼方式及采用压制，注射，单螺杆挤出３种不同成型方法对临界组成区域的热敏导电材料电性能及力学性能的影响规律，并对开炼，密炼两种工艺的混炼条件，加料方式及加料顺序进行了考察，结果表明，采用密炼工艺，炭黑（ＣＢ）粒子能得到均匀分布，电阻率较低，拉伸强度及断裂伸长率高，适中的剪切速率及温度有利于ＣＢ粒子分散，采用压制成型法所得样品各向同性。     

压缩空气冷冻胶粉生产技术研究

介绍了利用新型离心式粉碎机和人字形槽动静压混合式气体轴承透平膨胀机，采用普冷与压缩空气膨胀制冷相结合来生产精细胶粉的工艺路线及关键设备。这种技术具有操作方便、车间干净卫生、能耗低、关键设备可靠性好、生产效率高等特点     

一种基于滤波特征和不变矩的混合指纹识别算法

滤波特征匹配和不变矩匹配是常用的指纹识别算法,是将两种识别算法以一定的权值进行结合而提出的一种混合识别算法.通过采用来自不同手指采集的多幅指纹图像作为样本集并两两匹配,得到相应的滤波特征和不变矩匹配分数样本.而算法中权值的确定可以转换成一个匹配分数样本的分类器设计问题,用这些样本对权值进行分类学习估计.以100对指纹图像对混合识别算法进行测试,结果证明该算法具有较好的识别效果.     

基于PowerBuilder的S-P表差异系数计算与算法实现

S-P表评价法是计算机教育测量中一种重要的方法,差异系数是S-P表分析评价中反映S线和P线之间不一致程度的重要指标,通过计算差异系数,可以取得关于被测对象整体情况有价值的信息,为教学效果的改善提供依据。本文基于PowerBuilder软件提出实现算法,并给出流程图和主要源代码。