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41.
Soetikno V Watanabe K Sari FR Harima M Thandavarayan RA Veeraveedu PT Arozal W Sukumaran V Lakshmanan AP Arumugam S Suzuki K 《Molecular nutrition & food research》2011,55(11):1655-1665
Scope : We hypothesized that curcumin, a potent anti‐oxidant, might be beneficial in ameliorating the development of diabetic nephropathy through inhibition of PKC‐α and PKC‐β1 activity‐ERK1/2 pathway. Methods and results : Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) (55 mg/kg) in rats. Three weeks after STZ injection, rats were divided into three groups, namely, normal, diabetic and diabetic treated with curcumin at 100 mg/kg/day, p.o., for 8 wk. At 11 wk after STZ injection, diabetic rats exhibited renal dysfunction, as evidenced by reduced creatinine clearance, increased blood urea nitrogen (BUN) and proteinuria, marked increases in lipid peroxidation, NOX4 and p67phox and decrease in anti‐oxidant enzyme. All of these abnormalities were significantly reversed by curcumin. Furthermore, the high‐glucose‐induced PKC‐α and PKC‐β1 activities and phosphorylated ERK1/2 was significantly diminished by curcumin. Curcumin also attenuated the expression of TGF‐β1, CTGF, osteopontin, p300 and ECM proteins such as fibronectin and type IV collagen. The high‐glucose‐induced expression of VEGF and its receptor VEGF receptor II (flk‐1) was also ameliorated by curcumin. Conclusion : These results prove that curcumin produces dual blockade of both PKC‐α and PKC‐β1 activities, which suggests that curcumin is a potential adjuvant therapy for the prevention and treatment of diabetic nephropathy. 相似文献
42.
Dhanapal Venkatachalam Vijayakumar Vediappan Subramanian Kaliappa gounder 《应用聚合物科学杂志》2013,129(3):1350-1361
A series of superabsorbent polymers (SAP) were synthesized by free radical thermal copolymerization of acrylic acid and N‐isopropyl acrylamide monomers using trimethylolpropane triacrylate as crosslinker. They were characterized by FT‐IR and thermal stability (TGA/DTG), and evaluated for their water and fertilizer uptake and release characteristics under different crosslinker levels, temperature, pressure, and pH. The observed maximum absorption of water by the SAP was 1130 g/g of polymer. The release was modeled which showed a non‐Fickian mechanism. The water uptake of SAP was correlated with the average molecular weight between the crosslinks and crosslink density. Analysis of the weight loss data from TG in air revealed a zero order kinetics for the initial degradation step with an activation energy (AE) of 70.8 kJ/mol. The AEs for water uptake and release for thermal degradation were also determined through Arrhenius plots. The results inferred that the synthesized SAP can be exploited for commercial agricultural applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 相似文献
43.
C. Vijayakumar H. Padma Kumar Sam Solomon J.K. Thomas P.R.S. Wariar Annamma John 《Journal of Alloys and Compounds》2009,480(2):167-170
The nanoparticles of Ba2RESbO6 (RE = Sm, Gd, Dy and Y) were synthesized using auto ignition combustion process. The structure and phase purity of the as-prepared nanopowders were examined by X-ray diffraction pattern. A systematic analysis of the structure of the four compounds was carried out for the first time by recording Raman and IR spectra. The four Raman active modes A1g, Eg and 2F2g were observed as strong or medium intense bands in the Raman spectra and the IR active F1u(1) mode is obtained as a strong absorption band around 630 cm−1 in all the four compounds. Hence it is confirmed that the above compounds were crystallized in the cubic symmetry with space group. 相似文献
44.
12-Tungstophosphoric acid supported on montmorillonite K10 (PWA/mont-K10) catalysed Pechmann condensation reaction was reported.
The catalyst was characterized by XRD, FTIR, UV–Vis DRS, surface area and pore size analysis, TGA and acidity by DRIFTS using
pyridine. The morphology of the catalyst was studied by SEM. The activity of mont-K10, mont-KSF,
\textSO 4 2 - \mathord