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991.
The reaction between 4,5(E)-epoxy-2(E)-heptenal (EH) andl-lysine was studied to characterize some of the compounds that may be produced when proteins react with peroxidizing lipids.
A mixture of EH and lysine was incubated overnight at room temperature and then fractionated by high-performance liquid chromatography
(HPLC). Fractions were freeze-dried and characterized by1H and13C nuclear magnetic resonance (NMR) and mass spectrometry. Four major pyrrole derivatives were obtained, namely 1-(5′-amino-1′-carboxypentyl)-pyrrole
(3), 1-(5′-amino-1′-carboxypentyl)-2-(1″-hydroxypropyl)pyrrole (diastereomers 5 and 8), 1-(5′-amino-5′-carboxypentyl)pyrrole
(7), and 1-(5′-amino-5′-carboxypentyl)-2-(1″-hydroxypropyl)pyrrole (9). In addition, several lysine complexes were detected.
A polymer (1b) that was responsible for the color and the fluorescence produced in the reaction was isolated by gel filtration
chromatography from a fraction obtained by HPLC. Formation of pairs of analogs (5 and 3, 9 and 7) with and without a substituent
in position 2 of the pyrrole ring suggested that the compounds were produced by the same mechanism, with the formation of
the 2-unsubstituted pyrroles corresponding to the loss of the 2-substituent as propanal; propanal was detected by headspace
capillary gas chromatography. A reaction mechanism is proposed based on the NMR data obtained when the reaction was monitored
in real time in an NMR tube. The results suggest that pyrrolic amino acids 7 and 9 may be present in proteins that have been
damaged by peroxidizing lipids. 相似文献
992.
Female rats warm-adapted at 30–32 C for 20–25 days and then shifted to 13–15 C for 12, 24, 48, 72 and 120 hr showed that Δ9
desaturase and fatty acid synthetase activity decay after 24 hr of cold exposure, while Δ6 and Δ5 desaturases were increased
after this period of time. These results were confirmed by an increase of arachidonic acid of heart and liver microsomes phosphatidylcholine
and a decrease of oleic acid. Neither NADH-cyt b5 reductase nor NADH-cyt c reductase activity of liver microsomes were significantly affected. Male rats warm-adapted under
the same conditions and then shifted to 13–15 C for 120 hr did not show significant changes in fatty acid synthetase, Δ9 and
Δ6 desaturases and enzymes of the microsomal electron transport chain. Therefore, the desaturase response to environmental
temperature changes could be plausibly linked to female hormones. 相似文献
993.
Sn doped GeO(2) nanowires and microwires have been grown by an evaporation-deposition method, using a mixture of Ge and SnO(2) powders as precursors. Comparison with undoped GeO(2) nanowires grown by the same method shows that the presence of Sn prevents the formation of sharp bends, which makes the wires more suitable for waveguiding applications. Incorporation of about 0.5?at.% of Sn into the wires influences their morphology and gives rise to wires showing two different cross-sectional dimensions along the growth axis. Sn does not influence the luminescence spectra in the visible range but causes the appearance of emission bands in the near-infrared range. The waveguiding behavior of the Sn doped wires for green and red laser light has been demonstrated. 相似文献
994.
Dan Vladimir Nichita Fernando García-Snchez Susana Gmez 《Chemical engineering journal (Lausanne, Switzerland : 1996)》2008,140(1-3):509-520
Phase stability calculation is a very important topic in phase equilibrium modeling. Usually the phase stability problem is solved by minimization of the tangent plane distance (TPD) function, the sign of the objective function at its global minimum indicating the state of the mixture at given conditions. The TPD function is non-convex and may be highly non-linear, many phase stability problems being really challenging. The tunneling global optimization method had been successfully used for solving a variety of phase equilibrium problems, including stability, with cubic equations of state (EoS). In this work, we test the ability of the tunneling method to solve the phase stability problem for more complex EoS like PC-SAFT. Calculations are performed for several benchmark problems, for mixtures of non-associating molecules, from binaries to multicomponent. In one example, the mixture contains hydrogen sulphide, for which the three parameters required by the PC-SAFT EoS were unavailable in the literature. These parameters, as well as the binary interaction parameter (BIP) between hydrogen sulphide and methane, were calculated based on experimental data. 相似文献
995.
An experimental correlation between the non‐linear behaviour of commercial polyethylene melts in LAOS flow, and the pressure fluctuations associated with melt flow instabilities developed in capillary rheometry are presented. Polyethylene melts with enhanced non‐linear behaviour under LAOS conditions present larger pressure fluctuations during capillary extrusion, and consequently, larger surface distortions on the extrudate. The combination of both methods can be a tool to predict the development of melt flow instabilities in the extrusion process of polyethylene melts, and can elucidate their correlation with material structural properties ( , MWD and topology).
996.
Barbero S Marcos S 《Journal of the Optical Society of America. A, Optics, image science, and vision》2008,25(9):2280-2285
Wave aberrations in the human eye are usually known with respect to the ideal spherical wavefront in the exit pupil. Using Kirchhoff's diffraction theory, we have derived a diffraction integral to compute the optical field on the retina from the wave aberration data. We have proposed a numerical algorithm based on the Stamnes-Spjelkavik-Pedersen (SSP) method to solve that integral. We have shown which approximations are admissible to reduce the complexity of the diffraction integral. In addition, we have compared our results with those of the conventional procedure used to compute intensities on the retina. We have found significant differences between our results and the conventional ones. 相似文献
997.
998.
Javier Hidalgo 《TEST》1999,8(2):365-398
We consider a test for the selection of variables/covariates in a time series regression model based on aL
2-measure of global deviation between the nonparametric estimates of the regression model obtained under the null and alternative hypotheses.
Thus, the test can be viewed in the context of dimension reduction. Moreover, the test only requires, unlike others proposed
for the same hypothesis testing problem, the choice of one bandwidth parameter. We show that our test has power against contiguous
alternatives that converge to the null at a rateT
−α, in contrast to alternative tests whose rates areT
-α1, where 1/4 < α1 < α 1/2. Thus the asymptotic relative efficiency of their test compared to ours is zero. Finally, the test is extended to
the situation when the null follows a parametric model up to a finite set of parameters.
This article is based on research funded by the Economic and Social Research Council (ESRC) reference number: R000235892. 相似文献
999.
Garcia-Rodriguez Olaya; Secades-Villa Roberto; Higgins Stephen T.; Fernandez-Hermida Jose R.; Carballo Jose L.; Errasti Perez Jose M.; Diaz Susana Al-halabi 《Canadian Metallurgical Quarterly》2009,17(3):131
The aims of this study were to assess whether voucher magnitude improved cocaine abstinence and retention in an outpatient treatment for cocaine dependence, and to determine the effectiveness of a contingency management intervention in a European cultural context. A randomized controlled trial was conducted in which 96 participants who were randomly assigned to 1 of 3 treatment conditions in a community setting: standard outpatient treatment, community reinforcement approach (CRA) plus low monetary value vouchers (each point earned was equivalent to 0.125? US$ 0.18), and CRA plus high monetary value vouchers (each point was worth 0.25? US$ 0.36). In the standard treatment group, mean percentage of cocaine-negative samples was 88.45%, versus 96.09% in the CRA plus low-vouchers group, and 97.07% in the CRA plus high-vouchers group. Retention rate at 6 months was 36.5% in the standard treatment group, 53.3% in the CRA plus low-vouchers group, and 69.0% in the CRA plus high-vouchers group. The CRA plus vouchers groups obtained better results than the standard program. This study showed that treating cocaine addiction by combining CRA with vouchers was more effective than standard treatment in community outpatient programs in Spain. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
1000.
Beln Martín‐Matute Susana Isabel Pereira Eduardo Pea‐Cabrera Javier Adrio Artur M.S. Silva JuanC. Carretero 《Advanced Synthesis \u0026amp; Catalysis》2007,349(10):1714-1724
The synthesis of two Fesulphos‐based chiral ligands and their immobilization on a polystyrene support is described. These supported chiral ligands act as very efficient catalysts in 1,3‐dipolar cycloaddition and allylic substitution reactions providing the products with excellent enantioselectivities (91 to >99 % ee). Filtration of the catalyst from the reaction mixtures allows simple product isolation. The polymer‐supported Cu complex of chiral ligand PS‐ 8 can be recycled without further addition of a copper salt in 1,3‐dipolar cycloaddition reactions. 相似文献