Acute toxicity of synthetic Gymnodinium breve toxin metabolite and its analogues in mice

Accidental and operative trauma are able to induce a systemic reaction of the organism characterized by fever, leukocytosis, catabolism, and an activation of the coagulation system. Interleukin-6 (IL-6) has been found to be an important mediator of this acute-phase response. In this study the influence of elective craniotomy on IL-6 plasma levels was evaluated. Blood samples were obtained from 20 patients undergoing elective craniotomy for vascular or tumorous diseases of the brain. IL-6 increased significantly (p < 0.05) from the pre-operative (0(0-5.4) pg/ml) to the intraoperative (180 min after beginning of surgery) time-point (10.6 (0-18.5) pg/ml). The maximum was reached on the first postoperative morning (13.9(4.3-45.0) pg/ml). Interleukin-10 (IL-10) is an anti-inflammatory cytokine which suppresses IL-6 synthesis in vitro in various cell lines. IL-10 plasma concentrations showed no alterations throughout the study period. Epinephrine plasma concentrations increased significantly from pre-operative values (15 (0-74) pg/ml) to the postoperative time-point (57(9-459) pg/ml). A 4.5-fold increase (p < 0.05) of norepinephrine plasma concentrations was found when comparing the data obtained 60 min after beginning of surgery with the data of the first postoperative morning. In monocytes, which are a major source of plasma IL-6, an elevation of intracellular cAMP stimulates the IL-6 synthesis. The postoperative maximum of IL-6 in plasma could be due to a release of catecholamines. In conclusion this study demonstrated an elevation of IL-6 plasma concentrations during and after elective craniotomy. Increased plasma catecholamine concentrations as well as a damage in the blood-brain barrier due to the surgical trauma with a spill-over of IL-6 from brain tissue into plasma could have contributed to this result.     

Nutritional issues and therapy in inflammatory bowel disease

The molecular motions of D-alpha-galacturonic acid monohydrate (GA) and its derivative methyl-alpha-D-galacturonic acid methyl ester monohydrate (MGAM) in the solid state have been studied using 1H NMR. Both protonated and deuterium exchanged samples have been used. Spin-lattice relaxation times in the laboratory and rotating frames as well as second moments have been measured over the temperature range 90-370 K. Analysis of results has shown that in GA spin-lattice relaxation is chiefly by hydroxyl groups and water of crystallization. In MGAM, methyl groups dominate spin-lattice relaxation in the laboratory frame at the low temperature. Hydroxyl groups and water of crystallization contribute to the spin-lattice relaxation in the laboratory frame in the high temperature region. In the rotating frame motion of hydroxyl groups and water of crystallization provide the main relaxation pathway. Changes in the static second moment with temperature can be reasonably well predicted using values of correlation time and motionally averaged second moments obtained by fitting the spin-lattice relaxation data. 13C CPMAS spectra for GA and MGAM are also described.     

Scheduling and allocation in high-level synthesis using stochastic techniques

High-level synthesis is the process of automatically translating abstract behavioral models of digital systems to implementable hardware. Operation scheduling and hardware allocation are the two most important phases in the synthesis of circuits from behavioral specification. Scheduling and allocation can be formulated as an optimization problem. In this work, a unique approach to scheduling and allocation problem using the genetic algorithm (GA) is described. This approach is different from a previous attempt using GA (Wehn et al., IFIP Working Conference on Logic and Architecture Synthesis, Paris, 1990, pp. 47–56) in many respects. The main contributions include: (1) a new chromosomal representation for scheduling and for two subproblems of allocation; and (2) two novel crossover operators to generate legal schedules. In addition the application of tabu search (TS) to scheduling and allocation is also implemented and studied. Two implementations of TS are reported and compared. Both genetic scheduling and allocation (GSA) and tabu scheduling and allocation (TSA) have been tested on various benchmarks and results obtained for data-oriented control-data flow graphs are compared with other implementations in the literature. (A discussion on GSA was presented at the European Design Automation Conference Euro-DAC'94 in Grenoble, France, and TSA at the International Conference on Electronics, Circuits and Systems — ICECS'94 in Cairo, Egypt.) A novel interconnect optimization technique using the GA is also realized.     

Free vibration analysis of orthotropic plates by the initial value method

A modified method of the classical initial value technique is presented for the free vibration analysis of rectangular orthotropic plates. The method employs finite difference operators in one direction and uses integration in the other direction. The solutions are superimposed to satisfy the boundary conditions. A detailed discussion of the method is given. A comparative study is presented of the initial value method and other numerical methods. Three examples that show the accuracy of the method are presented.     

Inverse dual converter (IDC) for high-power DC-DC applications

A family of DC-DC converters suitable for high-power applications is introduced. The inverse dual converter (IDC) is capable of continuous voltage step-up or step-down control over a wide range of and without the need of a transformer. Experimental verification of the analysis is given for the simple single-phase IDC. Some of the more sophisticated members of the IDC family are described, and their characteristics and possible application, are mentioned     

Preparation of cupric palmitate membrane,its characterization and evaluation of thermodynamically effective fixed charge density

Membrane potentials have been measured across, parchment-supported cupric palmitate membrane separating various 1∶1 electrolytes at concentrations C₁ and C₂ such that C₂=10 C₁. Membrane potential data have been used to calculate transference number of ions, permselectivity and also to derive the thermodynamically effective fixed charge density which is an important characteristic governing the membrane phenomena, by utilizing the generally accepted and most widely used theory of Teorell-Meyer and Sievers as well as the recent theories for membrane potential of Kobatake et al. and Nagasawa et al. based on the principles of nonequilibrium thermodynamics. The values of charge densities derived from different theories were almost the same, confirming thereby the validity of the recently developed theories of membrane potential.