全文获取类型
收费全文 | 7444篇 |
免费 | 496篇 |
国内免费 | 38篇 |
学科分类
工业技术 | 7978篇 |
出版年
2024年 | 34篇 |
2023年 | 124篇 |
2022年 | 358篇 |
2021年 | 495篇 |
2020年 | 297篇 |
2019年 | 306篇 |
2018年 | 352篇 |
2017年 | 317篇 |
2016年 | 295篇 |
2015年 | 255篇 |
2014年 | 329篇 |
2013年 | 524篇 |
2012年 | 445篇 |
2011年 | 527篇 |
2010年 | 349篇 |
2009年 | 366篇 |
2008年 | 305篇 |
2007年 | 257篇 |
2006年 | 225篇 |
2005年 | 169篇 |
2004年 | 153篇 |
2003年 | 215篇 |
2002年 | 204篇 |
2001年 | 144篇 |
2000年 | 94篇 |
1999年 | 78篇 |
1998年 | 133篇 |
1997年 | 98篇 |
1996年 | 71篇 |
1995年 | 59篇 |
1994年 | 37篇 |
1993年 | 49篇 |
1992年 | 34篇 |
1991年 | 19篇 |
1990年 | 32篇 |
1989年 | 21篇 |
1988年 | 32篇 |
1987年 | 14篇 |
1986年 | 20篇 |
1985年 | 23篇 |
1984年 | 8篇 |
1983年 | 12篇 |
1982年 | 9篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 7篇 |
1977年 | 12篇 |
1976年 | 16篇 |
1975年 | 5篇 |
1973年 | 9篇 |
排序方式: 共有7978条查询结果,搜索用时 15 毫秒
131.
In this paper, we focus on the strategic design of supply chain networks. We propose a mathematical modeling framework that captures many practical aspects of network design problems simultaneously but which have not received adequate attention in the literature. The aspects considered include: dynamic planning horizon, generic supply chain network structure, external supply of materials, inventory opportunities for goods, distribution of commodities, facility configuration, availability of capital for investments, and storage limitations. Moreover, network configuration decisions concerning the gradual relocation of facilities over the planning horizon are considered. To cope with fluctuating demands, capacity expansion and reduction scenarios are also analyzed as well as modular capacity shifts. The relation of the proposed modeling framework with existing models is discussed. For problems of reasonable size, we report on our computational experience with standard mathematical programming software. In particular, useful insights on the impact of various factors on network design decisions are provided. 相似文献
132.
Jaffee Sara R.; Caspi Avshalom; Moffitt Terrie E.; Taylor Alan 《Canadian Metallurgical Quarterly》2004,113(1):44
The well-documented finding that child physical maltreatment predicts later antisocial behavior has at least 2 explanations: (a) Physical maltreatment causes antisocial behavior, and (b) genetic factors transmitted from parents to children influence the likelihood that parents will be abusive and that children will engage in antisocial behavior. The authors tested these hypotheses in the representative Environmental-Risk cohort of 1,116 twin pairs and their families, who were assessed when the twins were 5 and 7 years old. Mothers reported on children's experience of physical maltreatment, and mothers and teachers reported on children's antisocial behavior. The findings support the hypothesis that physical maltreatment plays a causal role in the development of children's antisocial behavior and that preventing maltreatment can prevent its violent sequelae. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
133.
McKay James R.; Lynch Kevin G.; Shepard Donald S.; Ratichek Sara; Morrison Rebecca; Koppenhaver Janelle; Pettinati Helen M. 《Canadian Metallurgical Quarterly》2004,72(6):967
This study of continuing care for substance dependent patients compared a telephone-based monitoring and brief counseling intervention (TEL) with 2 face-to-face interventions, relapse prevention (RP) and standard 12-step group counseling (STND). The participants were graduates of intensive outpatient programs who had current dependence on alcohol and/or cocaine. Self-report, collateral, and biological measures of alcohol and cocaine use were obtained over a 12-month follow-up. The treatment groups did not differ on abstinence-related outcomes in the complete sample (N = 359) or on cocaine use outcomes in participants with cocaine dependence (n = 268). However, in participants with alcohol dependence only (n = 91), TEL produced better alcohol use outcomes than STND on all measures examined and better outcomes than RP on some of the measures. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
134.
Szabo S Haislip AM Traina-Dorge V Costin JM Crawford BE Wilson RB Garry RF 《Microscopy research and technique》2005,68(3-4):209-221
Sequences highly similar (>95%) to the mouse mammary tumor virus (MMTV) env gene have been amplified from human DNA samples, including DNA samples from patients with breast cancer (BC) and persons who did not have BC. The sequences from human DNA were distinct from the MMTV sequences used as controls in these PCR reactions, indicating that these results are not simply due to contamination. In addition to both, mouse and human-related sequences were also amplified from some monkey and cat genomic DNA samples. These products were shown to be distinct from, but highly related to, the MMTV env gene, whereas, testing of other sources (lambda phage, snake, cockroach, sea urchin, chicken, or dog) demonstrated no specific amplification. A sequence 90% similar to the MMTV group antigen gene (gag) was amplified from cat DNA. These results indicate that DNA from vertebrate species other than rodents, including some but not all humans, monkeys, and cats, can contain sequences closely related to MMTV. 相似文献
135.
Dodd Alyson L.; Mansell Warren; Morrison Anthony P.; Tai Sara 《Canadian Metallurgical Quarterly》2011,23(3):635
The Hypomanic Attitudes and Positive Predictions Inventory (HAPPI; W. Mansell, 2006) was developed to assess multiple, extreme, self-relevant appraisals of internal states. The present study aimed to validate the HAPPI in a clinical sample. Participants (N = 50) with a diagnosis of bipolar disorder (confirmed by a structured clinical interview) completed a series of questionnaires pertaining to clinical factors, reward motivation, cognitive style, symptoms, and functioning at baseline, in addition to the HAPPI. Over the following 4 weeks, participants were asked to complete self-report measures of symptoms (activation, perceived conflict, depression, and well-being), as well as work and social functioning, twice weekly. The authors hypothesized that the HAPPI would be associated with prospective bipolar symptoms and functioning, when controlling for baseline symptoms and potentially confounding measures. The HAPPI was positively, independently associated with activation and conflict after 4 weeks. Furthermore, individual HAPPI factors were associated with activation, conflict, and depression. The results provided preliminary support for the predictive validity of the HAPPI in a clinical sample. The HAPPI could be used in the future as a tool in cognitive behavioral therapy for bipolar disorder to identify problematic beliefs and guide formulation. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
136.
介绍了国产酚醛层压板制成的阻性板室在宇宙线测试条件下的特性,效率达到95%左右,时间分辨的半高宽为2.25ns。 相似文献
137.
Inhibition of hIAPP Amyloid Aggregation and Pancreatic β‐Cell Toxicity by OH‐Terminated PAMAM Dendrimer 下载免费PDF全文
Esteban N. Gurzov Bo Wang Emily H. Pilkington Pengyu Chen Aleksandr Kakinen William J. Stanley Sara A. Litwak Eric G. Hanssen Thomas P. Davis Feng Ding Pu Chun Ke 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(12):1615-1626
Human islet amyloid polypeptide (hIAPP, or amylin) forms amyloid deposits in the islets of Langerhans, a phenomenon that is associated with type‐2 diabetes impacting millions of people worldwide. Accordingly, strategies against hIAPP aggregation are essential for the prevention and eventual treatment of the disease. Here, it is shown that generation‐3 OH‐terminated poly(amidoamine) dendrimer, a polymeric nanoparticle, can effectively halt the aggregation of hIAPP and shut down hIAPP toxicity in pancreatic MIN6 and NIT‐1 cells as well as in mouse islets. This finding is supported by high‐throughput dynamic light scattering experiment and thioflavin T assay, where the rapid evolution of hIAPP nucleation and elongation processes is halted by the addition of the dendrimer up to 8 h. Discrete molecular dynamics simulations further reveal that hIAPP residues bound strongly with the dendrimer near the c‐terminal portion of the peptide, where the amyloidogenic sequence (residues 22–29) locates. Furthermore, simulations of hIAPP dimerization reveal that binding with the dendrimer significantly reduces formation of interpeptide contacts and hydrogen bonds, thereby prohibiting peptide self‐association and amyloidosis. This study points to a promising nanomedicinal strategy for combating type‐2 diabetes and may have broader implications for targeting neurological disorders whose distinct hallmark is also amyloid fibrillation. 相似文献
138.
139.
Sara Oliveira Tamaeh Monteiro-Alfredo Rita Henriques Carlos Fontes Ribeiro Raquel Seia Teresa Cruz Clia Cabral Rosa Fernandes Ftima Piedade Maria Paula Robalo Paulo Matafome Snia Silva 《International journal of molecular sciences》2022,23(10)
Curcumin has been suggested as a promising treatment for metabolic diseases, but the high doses required limit its therapeutic use. In this study, a new curcuminoid is synthesised to increase curcumin anti-inflammatory and antioxidant potential and to achieve hypoglycaemic and protective vascular effects in type 2 diabetic rats in a lower dose. In vitro, the anti-inflammatory effect was determined through the Griess reaction, and the antioxidant activity through ABTS and TBARS assays. In vivo, Goto-Kakizaki rats were treated for 2 weeks with the equimolar dose of curcumin (40 mg/kg/day) or curcuminoid (52.4 mg/kg/day). Fasting glycaemia, insulin tolerance, plasma insulin, insulin signalling, serum FFA, endothelial function and several markers of oxidative stress were evaluated. Both compounds presented a significant anti-inflammatory effect. Moreover, the curcuminoid had a marked hypoglycaemic effect, accompanied by higher GLUT4 levels in adipose tissue. Both compounds increased NO-dependent vasorelaxation, but only the curcuminoid exacerbated the response to ascorbic acid, consistent with a higher decrease in vascular oxidative and nitrosative stress. SOD1 and GLO1 levels were increased in EAT and heart, respectively. Altogether, these data suggest that the curcuminoid developed here has more pronounced effects than curcumin in low doses, improving the oxidative stress, endothelial function and glycaemic profile in type 2 diabetes. 相似文献
140.
Laura Mannarino Lara Paracchini Federica Pezzuto Gheorghe Emilian Olteanu Laura Moracci Luca Vedovelli Irene De Simone Cristina Bosetti Monica Lupi Rosy Amodeo Alessia Inglesi Maurizio Callari Serena Penpa Roberta Libener Sara Delfanti Antonina De Angelis Alberto Muzio Paolo Andrea Zucali Paola Allavena Giovanni Luca Ceresoli Sergio Marchini Fiorella Calabrese Maurizio DIncalci Federica Grosso 《International journal of molecular sciences》2022,23(10)