Cytochrome P450 inhibitory potential of selected Indian spices — possible food drug interaction

Spices constitute an important group of food which is virtually indispensable in the culinary art. In a view, these spices feared to pose a probability to affect the disposition of conventional pharmaceuticals through inhibition of human cytochrome P450 (CYPs) enzymes. In the present study an approach has been made to evaluate the possible CYP inhibition potential with some Indian spices (Capsicum annuum, Murraya koenigii, Zingiber officinale) and their major bioactive compounds, in combination with pooled microsome; as well as commercially available recombinant human CYP3A4, CYP2D6, CYP2C9 and CYP1A2. Quantification of the bioactive compound was determined through RP-HPLC, in order to standardize the plant material. CYP–carbon monoxide (CYP–CO) complex assay result indicated that all the plants and their bioactive compounds have an interaction potential with CYPs. Fluoregenic assay results indicated that the spice extracts have higher inhibition potential comparing to their single bioactive molecule. The higher enzyme inhibition potential by the extracts may be related to the synergistic effects due to the presence of other constituents in the extract. Capsaicin and C. annuum showed the lowest IC₅₀ value and 6-gingerol and Z. officinale extract showed the highest IC₅₀ value among the entire sample tested. The entire sample showed significantly less (P < 0.001, P < 0.01) interaction potential than known inhibitors. These findings indicate that selected spices are unlikely to cause clinically relevant drug interactions involving the inhibition of major CYP isozymes.     

Line-focusing concentrating solar collector-based power plants: a review

Concentrated solar power (CSP) plant is an emerging technology among different renewable energy sources. Parabolic trough collector (PTC)-based CSP plant, using synthetic or organic oil as a heat-transfer fluid, is the most advanced technology. About 87 % of the operational capacities of CSP plants worldwide are based on PTC technology. Direct steam-generating linear Fresnel reflector (LFR) systems have been developed as a cost-effective alternative to PTC systems. Line-focusing concentrating solar collectors (PTC and LFR), with single-axis tracking, are simple in design and easy to operate. Prior to the detailed design of a CSP plant, it is necessary to finalize type of the solar field, type of the power-generating cycle, overall plant configuration, sizing of the solar field and the power block, etc. The optimal design of a CSP plant minimizes the levelized cost of energy for a given site. In this paper, a detailed review of important design parameters which affect the design of line-focusing concentrating solar collector-based power plants is presented. This includes parameters for solar collector field design, receiver, heat-transfer fluid, thermal energy storage, power-generating cycle, sizing and configuration of the plant, etc. This review may provide a reference for designing CSP plants. Future research directions are also identified.     

Emission constrained power system planning: a pinch analysis based study of Indian electricity sector

In the light of rising electricity demands and a need to curb carbon dioxide emissions, this article investigates the problem of power system planning with emission targeting. A pinch analysis based approach is utilised here. The key aspect of this study is investigating the parameters that decide the priority of one type of power plant over another. For this, a quantity called prioritised cost, a trade off between cost incurred and emission from a new power plant is identified. In addition to cost and emission factor of a power plant, a third parameter, the present state of the system, also plays a significant role in deciding a power plant’s prioritised cost. The analysis done proves that new power plants can be added to the system in the order of their prioritised cost. This methodology is applied to Indian power sector as a case study. Two different problems, involving minimisation of investment and annualised cost, are considered. It is observed that renewables are slightly more favoured when the objective is to minimise overall cost and not just the capital investment. In both cases, the energy mix is still dominated by coal-based power generation. The share of renewables was seen to increase with more stringent emission targets when the objective was to minimise overall cost.     

Aperture Field Estimation in E Plane and H-Plane T-Junctions Using Field Theoretic Analysis

Wireless Personal Communications - This paper presents method of moment based analysis of E Plane and H-Plane T-junctions to find the field distributions on different transverse and longitudinal...     

Green fire retardant finishing and combined dyeing of proteinous wool fabric

Flame retardancy was imparted to a scoured and bleached, proteinous woollen textile by using banana pseudostem sap, an ecofriendly waste agricultural product, at different pH levels. The flame retardancy characteristics of both the control and the treated fabrics were analysed in terms of the limiting oxygen index and the vertical flammability measurement. Thermal degradation and fire retardancy mechanisms were studied using thermogravimetry, scanning electron microscopy, and energy dispersive X‐ray analysis. Moreover, the charring mechanism of both the control and the banana‐pseudostem‐sap‐treated fabrics with varying pH was analysed and reported in detail. The wool fabric was also dyed with CI Acid Blue 25 using banana pseudostem sap as well as water as the medium. The fabric dyed with the banana pseudostem sap medium at pH 5.5 showed more colour exhaustion, colour strength, and thermal stability compared with the control wool fabric. The mechanism by which superior fire retardancy and colour strength are imparted to the woollen textile by the application of banana pseudostem sap is proposed.