Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA.     

The simplified two-pipette technique is more efficient than the conventional three-pipette method for blastomere biopsy in human embryos

Kell and Kx are two quantitatively minor proteins from the human erythrocyte membrane which carry blood groups antigens and are thought to be a metalloprotease and a membrane transporter, respectively. In the red cell membrane, these proteins form a complex stabilized by disulfide bond(s). Phosphorylation status of these proteins was studied, in the presence or absence of effectors of several kinases, either on intact cells incubated with [32P]-orthophosphate or on ghosts incubated with [gamma-32P]ATP. Purification of Kell-Kx complex, by immunochromatography on an immobilized human monoclonal antibody of Kell blood group specificity allowed to establish that (i) neither protein is phosphorylated on tyrosine; (ii) the Kell protein is a putative substrate for Casein Kinase II (CKII) and Casein Kinase I (CKI) but not for protein kinase C (PKC), whereas Kx protein is phosphorylated by CKII and PKC but not by CKI; (iii) Protein Kinase A neither phosphorylates the Kell nor the Kx proteins.     

Stability analysis for discrete linear systems with state saturation by a saturation-dependent Lyapunov functional

This paper concerns the stability analysis problem of discrete linear systems with state saturation using a saturation-dependent Lyapunov functional.We introduce a free matrix characterized by the sum of the absolute value of each elements for each row less than 1,which makes the state with saturation constraint reside in a convex polyhedron.A saturation-dependent Lyapunov functional is then designed to obtain a sufficient condition for such systems to be globally asymptotically stable.Based on this stability criterion,the state feedback control law synthesis problem is also studied.The obtained results are formulated in terms of bilinear matrix inequalities that can be solved by the presented iterative linear matrix inequality algorithm.Two numerical examples are used to demonstrate the effectiveness of the proposed method.     

城市架空线电缆化改造施工存在问题及解决办法

分析泉州市城市电缆化改造施工中存在的问题,提出了解决办法。     

隔离开关二次回路防误闭锁改造与应用

分析泉州电业局220kV老式变电站原隔离开关二次防误闭锁回路存在的隐患,针对改造前存在的安全问题,提出了改造措施。     

基于MACH 4002交换机的煤矿网络系统

以MACH 4002交换机为网络核心,分析了煤矿环境对网络系统的实时性、可靠性要求,比较了多种拓扑结构特性,给出了行之有效的建设方案。     

电视监控系统云台控制器设计

电视监控系统是一种典型的分布式计算机信号采集系统。为了提高监控的范围和效果,云台控制器的优劣直接影响监控的范围和效果,因此对云台控制器的设计具有重要的意义。本系统采用串型通信,通过Modbus协议把控制信号输入单片机,经过对AT89S52单片机的编程,从而对八路继电器输出进行控制。系统不仅结构简单,而且还可以方便的对镜头、防护罩的控制进行扩展,功能强大,可以广泛应用于电视监控系统中的云台控制。     

基于Android的多功能文件管理系统的设计与实现

文章所涉内容是一款基于Android的多功能文件管理系统的设计与实现。该设计以Android系统为开发平台,其目的是开发出一种方便用户使用的管理软件,使其具有文件浏览、文件权限的修改、添加文件到文件库、文件历史记录浏览、文件压缩以及文件加密等功能。     

改进BP网络在航材需求预测中的应用

针对航材备件需求预测问题,在对影响航材备件需求量的多个因素进行分析研究的基础上,运用改进BP神经网络算法进行预测的仿真实验。实验结果表明,改进BP神经网络能够对积累的历史数据进行充分的应用,并且有较高的预测准确性。     

掏挖与岩石锚杆复合型基础上拔承载机理和影响因素研究

针对掏挖与岩石锚杆复合型基础上拔承载机理不明确的问题,基于现场试验工况,利用Plaxis3D有限元软件建立复合型基础抗拔承载模型,研究其上拔承载机理。在此基础上,研究了土体弹性模量、岩体弹性模量、土体黏聚力对复合型基础各部分的承载影响,分析了掏挖基础和岩石群锚基础的承载力发挥情况、上拔变形、塑性区开展,并给出了复合型基础的改进方案。结果表明:上拔变形刚度较大的岩锚基础对复合型基础的承载极限状态起控制作用;掏挖基础和岩石锚杆基础的上拔变形协调性是影响复合型基础承载力发挥的关键;适当增加掏挖基础嵌入岩石的深度可有效提高复合型基础的抗拔承载力。