Male response to natural sex pheromone ofMigdolus fryanus westwood (Coleoptera: Cerambycidae) females as affected by daily climatic factors

Males of the sugarcane borer,Migdolus fryanus (Coleoptera: Cerambycidae), are attracted to females by means of a sex pheromone. Mating usually occurs during a few days from October to March under field conditions in São Paulo State, Brazil. This work reports on mating of this species as affected by daily climatic factors, during a single nuptial flight. Maximum male capture by the natural sex pheromone occurred from 1000 to 1100 AM at air and soil temperatures of 30.0°C and relative humidity of 57.0%. As these temperatures increased, females burrowed into the soil, as they are more sensitive to heat than males. Thus, it was concluded that sex pheromone-mediated mating in this cerambycid is directly affected by temperatures of air and soil.     

The phase behavior of n-alkane systems

Normal alkanes show very complicated phase transition kinetics and macroscopic phase equilibrium behavior. This paper focuses on the phase stability and equilibrium of complicated mixtures like n-alkanes and on the enabling global optimization technologies needed to gather problem knowledge. The new ideas contained in this paper include:

(1) novel level set methods for gathering encoded knowledge;

(2) the differential geometry for uncovering pathways to more subtle knowledge;

(3) all supporting non-linearly constrained optimization techniques;

(4) all data handling needed to unravel complex solution structure.

These new ideas are incorporated within the integral path methodology or terrain methods recently developed by Lucia, A., & Yang, F. (2003) [Lucia, A., & Yang F. (2003). Multivariable terrain methods. AIChE Journal 49, 2553] and Lucia, DiMaggio, and Depa (2004) [Lucia, A., DiMaggio, P.A., & Depa, P. (2004). A geometric terrain methodology for global optimization. Journal of Global Optimization 29, 297]. This framework provides global knowledge for understanding solution structure, like the complex solution structure of n-alkanes. In particular, it is shown that knowledge of the Newton and tangent vector fields, Gauss curvature, integral path bifurcation points, and non-differentiable manifolds provides a deterministic way of finding additional solutions, saddle points, and other information that might otherwise go undetected.It is shown that the optimization tools developed in this work provide all knowledge of interest on the appropriate hypothetical single-phase or composite surface (i.e., minima, saddle points, singular points, and integral paths) in phase stability applications. This knowledge can be obtained by solving the phase stability problem exactly once, in a pre-processing step, and used to reliably initialize any multi-phase equilibrium calculation for any feed. This removes the need to repeatedly solve the phase stability problem as the feed composition changes and greatly increases computational efficiency. Numerical examples and geometric illustrations are used to elucidate key ideas and to show how the proposed approach can be used to unravel the complicated phase behavior of n-alkane mixtures.     

The pure rotational spectrum of water vapor—A millimeter,submillimeter, and far infrared analysis

Line positions, strengths, and absolute energies are calculated for the pure rotational spectrum of water in the region between 0 cm^?1 and 877 cm^?1. These calculations are done in the context of a reduced centrifugal distortion Hamiltonian, and are based on microwave measurements of this spectrum to 1 THz, and Far Infrared measurements between 32 cm^?1 and 715 cm^?1.     

Novel high intrinsic dimensionality estimators

Recently, a great deal of research work has been devoted to the development of algorithms to estimate the intrinsic dimensionality (id) of a given dataset, that is the minimum number of parameters needed to represent the data without information loss. id estimation is important for the following reasons: the capacity and the generalization capability of discriminant methods depend on it; id is a necessary information for any dimensionality reduction technique; in neural network design the number of hidden units in the encoding middle layer should be chosen according to the id of data; the id value is strongly related to the model order in a time series, that is crucial to obtain reliable time series predictions. Although many estimation techniques have been proposed in the literature, most of them fail on noisy data, or compute underestimated values when the id is sufficiently high. In this paper, after reviewing some of the most important id estimators related to our work, we provide a theoretical motivation of the bias that causes the underestimation effect, and we present two id estimators based on the statistical properties of manifold neighborhoods, which have been developed in order to reduce this effect. We exhaustively evaluate the proposed techniques on synthetic and real datasets, by employing an objective evaluation measure to compare their performance with those achieved by state of the art algorithms; the results show that the proposed methods are promising, and produce reliable estimates also in the difficult case of datasets drawn from non-linearly embedded manifolds, characterized by high?id.     

An extensible system for source code analysis

Constructing code analyzers may be costly and error prone if inadequate technologies and tools are used. If they are written in a conventional programming language, for instance, several thousand lines of code may be required even for relatively simple analyses. One way of facilitating the development of code analyzers is to define a very high-level domain-oriented language and implement an application generator that creates the analyzers from the specification of the analyses they are intended to perform. This paper presents a system for developing code analyzers that uses a database to store both a no-loss fine-grained intermediate representation and the results of the analyses. The system uses an algebraic representation, called F(p), as the user-visible intermediate representation. Analyzers are specified in a declarative language, called F(p)-l, which enables an analysis to be specified in the form of a traversal of an algebraic expression, with access to, and storage of, the database information the algebraic expression indices. A foreign language interface allows the analyzers to be embedded in C programs. This is useful for implementing the user interface of an analyzer, for example, or to facilitate interoperation of the generated analyzers with pre-existing tools. The paper evaluates the strengths and limitations of the proposed system, and compares it to other related approaches     

Electrocatalytic properties and electrochemical stability of polyaniline and polyaniline modified with platinum nanoparticles in formaldehyde medium

We report the electro-oxidation of formaldehyde on polyaniline films modified with Pt nanoparticles (PANI-Pt films) in an aqueous sulfuric acid solution. The electrodeposition of Pt particles on the PANI matrix was found to promote a mass loss of the film, with a similar effect occurring after cycling the PANI films in the acidic medium containing formaldehyde. However, despite the electrochemical instability of PANI-Pt films, on films containing larger amounts of incorporated Pt particles, the oxidation of formaldehyde produces adsorbed CO species (CO_ads) at a lower positive potential than on bulk Pt. Our findings also indicate that electro-oxidation of CO_ads on the PANI-Pt film surface depends not only on the thickness of PANI film but also on the amount of Pt particles incorporated into the PANI matrix.     

A DNA Methyltransferase Modulator Inspired by Peyssonenyne Natural Product Structures

A novel epigenetic modulator that displays a DNMT1 inhibition and DNMT3A activation profile was characterized (compound 8 ). This compound is a derivative of palmitic acid that incorporates the putative reactive functional group (diynone) of the peyssonenyne natural products. Other analogues containing the diynone or an acetoxyenediyne did not show the same biological profile. In U937 human leukemia cells, diynone 8 induced cell differentiation and apoptosis, which correlated with the expression of Fas protein. Very surprisingly, diynone 8 was toxic to normal human fibroblasts (BJ) and mouse embryo fibroblasts (MEF), but not to immortalized human fibroblasts (BJEL); this unique effect was not observed with the classical DNMT inhibitor 5‐azacytidine. Therefore, compound 8 interferes in a very specific manner with signaling pathways, the activities of which differ between normal and immortalized cell types. This toxicity is reminiscent of the effects of Dnmt1 ablation on mouse fibroblasts. In fact, some of the genes deregulated by the loss of Dnmt1 are similarly deregulated by 8 , but not by the DNMT inhibitor SGI‐1027.     

The Impact of Nonalcoholic Fatty Liver Disease on Renal Function in Children with Overweight/Obesity

The association between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease has attracted interest and attention over recent years. However, no data are available in children. We determined whether children with NAFLD show signs of renal functional alterations, as determined by estimated glomerular filtration rate (eGFR) and urinary albumin excretion. We studied 596 children with overweight/obesity, 268 with NAFLD (hepatic fat fraction ≥5% on magnetic resonance imaging) and 328 without NAFLD, and 130 healthy normal-weight controls. Decreased GFR was defined as eGFR < 90 mL/min/1.73 m². Abnormal albuminuria was defined as urinary excretion of ≥30 mg/24 h of albumin. A greater prevalence of eGFR < 90 mL/min/1.73 m² was observed in patients with NAFLD compared to those without liver involvement and healthy subjects (17.5% vs. 6.7% vs. 0.77%; p < 0.0001). The proportion of children with abnormal albuminuria was also higher in the NAFLD group compared to those without NAFLD, and controls (9.3% vs. 4.0% vs. 0; p < 0.0001). Multivariate logistic regression analysis revealed that NAFLD was associated with decreased eGFR and/or microalbuminuria (odds ratio, 2.54 (confidence interval, 1.16–5.57); p < 0.05) independently of anthropometric and clinical variables. Children with NAFLD are at risk for early renal dysfunction. Recognition of this abnormality in the young may help to prevent the ongoing development of the disease.     

巨人的花园——对不同尺度棕地的差异化策略

近几十年来，旧工业区转型的项目不断增加，范围日益扩大，内涵不断扩充，被认为是城市改造的主要途径。工业区的转型不仅是自身的需要，而且经常能提供一个现实的机会来设想与城市在功能和关系上的深远变化。因为实施的连续性和话题的扩展性，这种转型要放在社会、技术和国际化变化的语境下，考虑典型的城市改造过程中的周期性活力，作为持续演变的效果来进行分析。这种改善往往受到多方面影响，包括：该地区最初的设计、与城市中断了的互动、新的机遇以及潜在的需求。所以，转型不仅意味着现存物质空间的改变，往往还作为观念工具，提供区域层面的解决之道。