First nuclear transmutation of 237Np and 241Am by accelerator-driven system at Kyoto University Critical Assembly

This study demonstrates, for the first time, the principle of nuclear transmutation of minor actinide (MA) by the accelerator-driven system (ADS) through the injection of high-energy neutrons into the subcritical core at the Kyoto University Critical Assembly. The main objective of the experiments is to confirm fission reactions of neptunium-237 (²³⁷Np) and americium-241 (²⁴¹Am), and capture reactions of ²³⁷Np. Subcritical irradiation of ²³⁷Np and ²⁴¹Am foils is conducted in a hard spectrum core with the use of the back-to-back fission chamber that obtains simultaneously two signals from specially installed test (²³⁷Np or ²⁴¹Am) and reference (uranium-235) foils. The first nuclear transmutation of ²³⁷Np and ²⁴¹Am by ADS soundly implemented by combining the subcritical core and the 100 MeV proton accelerator, and the use of a lead-bismuth target, is conclusively demonstrated through the experimental results of fission and capture reaction events.     

Effect of pre-oxidation on reactivity of chars in steam

The effects of pre-oxidation of char from Taiheiyo coal, a non-caking bituminous coal, in the 400–550 °C temperature range on its gasification reactivity with N₂-H₂O at 0.1 MPa (steam partial pressure of 13.2 kPa) have been investigated. The pre-oxidation of char markedly enhances gasification rates at temperatures between 800 and 900 °C. Reactivity is found to parallel the burn-off level during preoxidation at low temperatures (400–430 °C), whereas at relatively high temperatures (480–550 °C), the burn-off level only affects the reactivity slightly. The amount of CO and CO₂ evolved from the preoxidized char by heat treatment is proportional to the burn-off level at low temperatures (400–430 °C), being closely related to the enhancement of the gasification reactivity in steam.     

Molecular Design and Synthesis of a Novel Substrate for Assaying Lysozyme Activity

A novel substrate {Galβ1,4GlcNAcβ1,4GlcNAc-β-pNP [Gal(GlcNAc)₂-β-pNP]} for assaying lysozyme activity has been designed using docking simulations and enzymatic synthesis via β-1,4-galactosyltransferase-mediated transglycosylation from UDP-Gal as the donor to (GlcNAc)₂-β-pNP as the acceptor. Hydrolysis of the synthesized Gal(GlcNAc)₂-β-pNP and related compounds using hen egg-white lysozyme (HEWL) demonstrated that the substrate was specifically cleaved to Gal(GlcNAc)₂ and p-nitrophenol (pNP). A combination of kinetic studies and docking simulation was further conducted to elucidate the mode of substrate binding. The results demonstrate that Gal(GlcNAc)₂-β-pNP selectively binds to a subsite of lysozyme to liberate the Gal(GlcNAc)₂ and pNP products. The work therefore describes a new colorimetric method for quantifying lysozyme on the basis of the determination of pNP liberated from the substrate.     

Three-dimensional time-averaged void fraction distribution measurement technique for BWR thermal hydraulic conditions using an X-ray CT system

We have developed a void fraction distribution measurement technique using the three-dimensional (3D) time-averaged X-ray computed tomography (CT) system to understand two-phase flow behavior inside a fuel bundle for boiling water reactor (BWR) thermal hydraulic conditions of 7.2 MPa and 288 °C. As a first step, we measured the 3D void fraction distribution in a vertical square (5?×?5) rod array that simulated a BWR fuel bundle in the air–water test. A comparison of the volume-averaged void fractions evaluated by the developed X-ray CT system with those evaluated by a differential pressure transducer showed satisfactory agreement within a difference of 0.03. Thus, we confirmed that the developed system could be used to get 3D imaging of the vertical square rod array used in the test under the BWR operating pressure condition. In the next step, we did a verification test using the vertical pipe (11.3 mm ID) for BWR thermal hydraulic conditions. A comparison of the cross-sectional-averaged void fractions evaluated by the X-ray CT system with those evaluated by the drift-flux model showed good agreement within a difference of 0.05. We confirmed that the evaluated void fraction distribution forms in the horizontal cross section changed with the quality in response to the flow regime transition.     

Role of Metabolism in Bone Development and Homeostasis

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.     

Contents of eight harmful elements in baby toys and their migration tests

Levels of eight harmful elements, i.e., antimony, arsenic, barium, cadmium, chromium, lead, mercury and selenium, were investigated in 45 baby toys and 10 paints, which were mainly made of polyvinyl chloride. All samples contained barium at levels of 0.3-3,700 mg/kg, several samples contained cadmium (0.2-26 mg/kg), chromium (0.5-280 mg/kg) and lead (1.5-1,300 mg/kg), and one sample contained antimony (5.3 mg/kg). They might have been used as colorants of the toy materials and paints. They were then evaluated using the migration test of ISO 8124-3, in which samples were ground up, and then soaked in 0.07 mol/L HCl at 37 degrees C for two hours. Barium, cadmium, chromium and lead migrated from some of the samples, but at levels lower than the migration limits required by ISO 8124-3. Compared with the Japanese official method, the ISO method resulted in higher migration, but there are significant differences in the migration limits, test method, and so on between them. Further investigation is needed in this area.     

Ultra-high-precision time control system over any long time delay for laser pump and synchrotron x-ray probe experiment

An ultra-high-precision clock system for long time delay has been developed for picosecond time-resolved x-ray diffraction measurements using synchrotron radiation (SR) pulses and synchronized femtosecond laser pulses. The time delay control between pump laser pulse and the probe SR pulse was achieved by combining an in-phase quadrature modulator and a synchronous counter. This method allowed us to change the delay time by a nearly infinite amount while maintaining the precision of +/-8.40 ps. Time-resolved diffraction measurements using the delay control system were demonstrated for precise measurement of an acoustic velocity in a single crystal of gallium arsenide.     

A comparison of two-dimensional techniques for converting magnetocardiogram maps into effective current source distributions

The aim of this study was to develop a method for converting the pseudo two-dimensional current given by a current-arrow map (CAM) into the physical current. The physical current distribution is obtained by the optimal solution in a least mean square sense with Tikhonov regularization (LMSTR). In the current dipole simulation, the current pattern differences (ΔJ) between the results of the CAM and the LMSTR with several regularization parameters (α = 10(-1)-10(-15)) are calculated. In magnetocardiographic (MCG) analysis, the depth (z(d)) of a reconstruction plane is chosen by using the coordinates of the sinus node, which is estimated from MCG signals at the early p-wave. The ΔJs at p-wave peaks, QRS-complex peaks, and T-wave peaks of MCG signals for healthy subjects are calculated. Furthermore, correlation coefficients and regression lines are also calculated from the current values of the CAM and the LMSTR during p-waves, QRS-complex, and T-waves of MCG signals. In the simulation, the ΔJs (α ≈ 10(-10)) had a minimal value. The ΔJs (α = 10(-10)) at p-wave peaks, QRS-complex peaks, and T-wave peaks of MCG signals for healthy subjects also had minimal value. The correlation coefficients of the current values given by the CAM and the LMSTR (α = 10(-10)) were greater than 0.9. Furthermore, slopes (y) of the regression lines are correlated with the depth (z(d)) (r = -0.93). Consequently, the CAM value can be transformed into the LMSTR current value by multiplying it by the slope (y) obtained from the depth (z(d)). In conclusion, the result given by the CAM can be converted into an effective physical current distribution by using the depth (z(d)).     

Threshold Stress for Crack Healing of Mullite Reinforced by SiC Whiskers and SiC Particles and Resultant Fatigue Strength at the Healing Temperature

A mullite/SiC whisker/SiC particle multi-composite, having excellent crack-healing ability and mechanical properties, was hot pressed in order to investigate the crack-healing behavior under stress and the resultant fatigue strength at the temperature of healing. A semi-elliptical surface crack 100 μm in surface length was introduced on each specimen. The pre-cracked specimens were crack healed under cyclic or constant stress by using a three-point bending stress at 1473 K, and the resultant bending strength and cyclic fatigue strength were measured at 1473 K. The pre-crack on the surface of the specimens could be healed even under stress. The threshold stresses for crack healing, as determined by evaluating the strengths of crack-healed specimens at a healing temperature of 1473 K, were 170 MPa for both constant and cyclic stresses, corresponding to 77% of the bending strength of the pre-cracked specimens. The static and cyclic fatigue behaviors of crack-healed specimens were also investigated at a healing temperature of 1473 K.