Neural network technique for fuzzy multiobjective linear programming

Neural Network(NN) is well-known as one of powerful computing tools to solve optimization problems. Due to the massive computing unit-neurons and parallel mechanism of neural network approach we can solve the large-scale problem efficiently and optimal solution can be gotten. In this paper, we intoroduce improvement of the two-phase approach for solving fuzzy multiobjectve linear programming problem with both fuzzy objectives and constraints and we propose a new neural network technique for solving fuzzy multiobjective linear programming problems. The procedure and efficiency of this approach are shown with numerical simulations.     

The Detection of Immunity against WT1 and SMAD4P130L of EpCAM+ Cancer Cells in Malignant Pleural Effusion

Malignant pleural effusion (MPE) provides a liquid tumor microenvironment model that includes cancer cells and immune cells. However, the characteristics of tumor antigen-specific CD8⁺ T cells have not been investigated in detail. Here, we analyzed MPE samples taken from a patient with pancreatic cancer who received a dendritic cell vaccine targeting Wilms’ Tumor 1 (WT1) antigen over the disease course (two points at MPE^1st and 2^nd, two months after MPE1^st). Epithelial cell adhesion molecule (EpCAM)⁺ cancer cells (PD-L1⁻ or T cell immunoglobulin mucin-3, TIM-3⁻), both PD-1 or TIM-3 positive CD8⁺ T cells, and CD14⁺CD68⁺CD163⁺TIM-3⁺ macrophages increased from the MPE^1st to MPE^2nd. The ratio of WT1-specific cytotoxic lymphocytes (WT1-CTLs) to MPE CD8⁺ T cells and IFN-γ secretion of WT1-CTLs were reduced with disease progression. Coincidentally, the fraction of central memory T (T_CM) of WT1-CTLs was decreased. On the other hand, CD8⁺ T cells in response to SMAD4^P130L, which is homogeneously expressed in EpCAM⁺ cancer cells, were detected using in vitro expansion with the HLA-A*11:01 restrictive SVCVNLYH neoantigen. Furthermore, the CD8⁺ T cell response to SMAD4^P130L was diminished following remarkably decreased numbers of CD8⁺ T_CM in MPE samples. In conclusion, CD8⁺ T cells responding to WT1 or SMAD4^P130L neoantigen expressed in EpCAM⁺ pancreatic cancer cells were detected in MPE. A tumor antigen-specific immune response would provide novel insight into the MPE microenvironment.     

Back‐channel‐etched thin‐film transistor using c‐axis‐aligned crystal In–Ga–Zn oxide

Our crystalline In–Ga–Zn oxide (IGZO) thin film has a c‐axis‐aligned crystal (CAAC) structure and maintains crystallinity even on an amorphous base layer. Although the crystal has c‐axis alignment, its a‐axis and b‐axis have random arrangement; moreover, a clear grain boundary is not observed. We fabricated a back‐channel‐etched thin‐film transistor (TFT) using the CAAC‐IGZO film. Using the CAAC‐IGZO film, more stable TFT characteristics, even with a short channel length, can be obtained, and the instability of the back channel, which is one of the biggest problems of IGZO TFTs, is solved. As a result, we improved the process of manufacturing back‐channel‐etched TFTs.     

Ultrashort X-ray pulse generation using subpicosecond electron linac

As a promising tool for ultrafast material analyses, we propose to utilize the X-ray pulse which may be generated in a quite simple manner using subpicosecond electron linacs. The properties of the X-ray were numerically studied with the EGS4 code. Verification of the X-ray generation was also conducted at the Nuclear Engineering Research Laboratory (NERL) linac and clear diffraction patterns of characteristic X-ray were obtained for typical single crystals.     

Linear programming software tools on UNIX System

Linear programming(LP) is one of the most widely used Operations Research/Management Science/Industrial Engineering techniques. Recently, multiple criteria decision making or multiple objective linear programming has been well established as a practical approach to seeking satisfactory solutions to real-world decision problems.

In this paper we develop software tools for solving various linear programming problems such as a traditional LP problem, bicriteria LP problem, and multi-criteria LP problem on UNIX system. In a phase for reading data of various LP problems, we define a BNF(Backus-Nauel form) of various LP problems and implement BNF rules by using the C programming language.

In a phase for computing various LP problems, we use efficient methods for solving LP problems, develop various software tools on UNIX system, and combine each LP tool corresponding to an user request in which the Shell programming is used.

We also demonstrate some real-world LP problems by using LP software tools developed here on an UNIX System. Sanyo MPS 020.     

Universality Issues in Reversible Computing Systems and Cellular Automata (Extended Abstract)

In this survey, we deal with the problem how a universal computer can be constructed in a reversible environment. We discuss this problem based on the frameworks of reversible Turing machines, reversible logic circuits, and reversible cellular automata. We can see that in spite of the constraint of reversibility, there are several very simple reversible systems that have universal computing ability.     

Wearable vibrotactile systems for virtual contact and information display

This paper presents a development history of a wearable, scalable vibrotactile stimulus delivery system. This history has followed a path from desktop-based, fully wired systems, through hybrid approaches consisting of a wireless connection from the host computer to a body-worn control box and wires to each tactor, to a completely wireless system employing Bluetooth technology to connect directly from the host to each individual tactor unit. Applications for such a system include delivering vibrotactile contact cues to users of virtual environments, providing directional cues in order to increase situational awareness in both real and virtual environments, and for general information display in wearable contexts. Through empirical study, we show that even a simple configuration, such as eight tactors arrayed around the torso, can be effective in increasing situational awareness in a building-clearing task, compared to users who perform the same task without the added cues.     

Contents of eight harmful elements in baby toys and their migration tests

Levels of eight harmful elements, i.e., antimony, arsenic, barium, cadmium, chromium, lead, mercury and selenium, were investigated in 45 baby toys and 10 paints, which were mainly made of polyvinyl chloride. All samples contained barium at levels of 0.3-3,700 mg/kg, several samples contained cadmium (0.2-26 mg/kg), chromium (0.5-280 mg/kg) and lead (1.5-1,300 mg/kg), and one sample contained antimony (5.3 mg/kg). They might have been used as colorants of the toy materials and paints. They were then evaluated using the migration test of ISO 8124-3, in which samples were ground up, and then soaked in 0.07 mol/L HCl at 37 degrees C for two hours. Barium, cadmium, chromium and lead migrated from some of the samples, but at levels lower than the migration limits required by ISO 8124-3. Compared with the Japanese official method, the ISO method resulted in higher migration, but there are significant differences in the migration limits, test method, and so on between them. Further investigation is needed in this area.     

Threshold Stress for Crack Healing of Mullite Reinforced by SiC Whiskers and SiC Particles and Resultant Fatigue Strength at the Healing Temperature

A mullite/SiC whisker/SiC particle multi-composite, having excellent crack-healing ability and mechanical properties, was hot pressed in order to investigate the crack-healing behavior under stress and the resultant fatigue strength at the temperature of healing. A semi-elliptical surface crack 100 μm in surface length was introduced on each specimen. The pre-cracked specimens were crack healed under cyclic or constant stress by using a three-point bending stress at 1473 K, and the resultant bending strength and cyclic fatigue strength were measured at 1473 K. The pre-crack on the surface of the specimens could be healed even under stress. The threshold stresses for crack healing, as determined by evaluating the strengths of crack-healed specimens at a healing temperature of 1473 K, were 170 MPa for both constant and cyclic stresses, corresponding to 77% of the bending strength of the pre-cracked specimens. The static and cyclic fatigue behaviors of crack-healed specimens were also investigated at a healing temperature of 1473 K.