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Anna Martina Tedeschi Fabrizio Di Caprio Antonella Piozzi Francesca Pagnanelli Iolanda Francolini 《International journal of molecular sciences》2022,23(1)
This study combines the use of corn starch and Tetradesmus obliquus microalgae for the production of antioxidant starch films as flexible packaging material. Starch was plasticized with glycerol and blended with 1 w% polyallylamine chosen as an agent to modify the film physical properties. The addition of polyallylamine improved film water stability and water vapor transmission rate as well as mechanical stiffness and tenacity. The dried Tetradesmus obliquus microalgae, which showed an EC50 value of 2.8 mg/mg DPPH (2.2-Diphenyl-1-picrylhydrazyl radical), was then used as antioxidant filler. The addition of microalgae provided the films with good antioxidant activity, which increased with microalgae content increasing. To our knowledge, this is the first study reporting the development of sustainable bioactive packaging films composed of almost 100% starch, and follows the European union’s goals on plastics strategy concerning the promotion of bio-based, compostable plastics and the setting up of approaches to prevent food waste with a simple plastic packaging. 相似文献
44.
Claudia Penna Saveria Femmin Fabrizio Caldera Alberto Rubin Pedrazzo Claudio Cecone Edoardo Alfì Stefano Comit Takanobu Higashiyama Francesco Trotta Pasquale Pagliaro Roberta Cavalli 《International journal of molecular sciences》2021,22(8)
Heart failure (HF) prevalence is increasing among the aging population, and the mortality rate remains unacceptably high despite improvements in therapy. Myocardial ischemia (MI) and, consequently, ischemia/reperfusion injury (IRI), are frequently the basis of HF development. Therefore, cardioprotective strategies to limit IRI are mandatory. Nanocarriers have been proposed as alternative therapy for cardiovascular disease. Controlled reoxygenation may be a promising strategy. Novel nanocarriers, such as cyclic nigerosyl-nigerose (CNN), can be innovative tools for oxygen delivery in a controlled manner. In this study we analyzed new CNN-based formulations as oxygen nanocarriers (O2-CNN), and compared them with nitrogen CNN (N2-CNN). These different CNN-based formulations were tested using two cellular models, namely, cardiomyoblasts (H9c2), and endothelial (HMEC) cell lines, at different concentrations. The effects on the growth curve during normoxia (21% O2, 5% CO2 and 74% N2) and their protective effects during hypoxia (1% O2, 5% CO2 and 94% N2) and reoxygenation (21% O2, 5% CO2 and 74% N2) were studied. Neither O2-CNN nor N2-CNN has any effect on the growth curve during normoxia. However, O2-CNN applied before hypoxia induces a 15–30% reduction in cell mortality after hypoxia/re-oxygenation when compared to N2-CNN. O2-CNN showed a marked efficacy in controlled oxygenation, which suggests an interesting potential for the future medical application of soluble nanocarrier systems for MI treatment. 相似文献
45.
Igor Maria De Rosa Carlo Santulli Fabrizio Sarasini Marco Valente 《Polymer Composites》2009,30(12):1879-1887
The production of glass/plant fiber hybrid laminates is a possibility for obtaining semistructural materials with sufficient impact properties, and a better life cycle analysis (LCA) profile than fiberglass. The simplest and possibly the most effective configuration for the production of these hybrids would involve the use of a plant fiber reinforced laminate as the core between two glass fiber reinforced laminates. A main limitation to the use of composites including plant fibers is that their properties may be significantly affected by the presence of damage, so that even the application of a low stress level can result in laminate failure. In particular, it is suggested that when loading is repeatedly applied and removed, residual properties may vary in an unpredictable way. In this work, E‐glass/jute hybrid reinforced laminates, impacted in a range of energies (10, 12.5, and 15 J), have been subjected to post‐impact cyclic flexural tests with a step loading procedure. This would allow evaluating the effect of damage dissipation offered by the plant fiber reinforced core. The tests have also been monitored by acoustic emission (AE), which has confirmed the existence of severe limitations to the use of this hybrid material when impacted at energies close to penetration. POLYM. COMPOS., 2009. © 2009 Society of Plastics Engineers 相似文献
46.
Bazzicalupi C Chioccioli M Sissi C Porcù E Bonaccini C Pivetta C Bencini A Giorgi C Valtancoli B Melani F Gratteri P 《ChemMedChem》2010,5(12):1995-2005
Three novel 2,7-substituted acridine derivatives were designed and synthesized to investigate the effect of this functionalization on their interaction with double-stranded and G-quadruplex DNA. Detailed investigations of their ability to bind both forms of DNA were carried out by using spectrophotometric, electrophoretic, and computational approaches. The ligands in this study are characterized by an open-chain (L1) or a macrocyclic (L2, L3) framework. The aliphatic amine groups in the macrocycles are joined by ethylene (L2) or propylene chains (L3). L1 behaved similarly to the lead compound m-AMSA, efficiently intercalating into dsDNA, but stabilizing G-quadruplex structures poorly, probably due to the modest stabilization effect exerted by its protonated polyamine chains. L2 and L3, containing small polyamine macrocyclic frameworks, are known to adopt a rather bent and rigid conformation; thus they are generally expected to be sterically impeded from recognizing dsDNA according to an intercalative binding mode. This was confirmed to be true for L3. Nevertheless, we show that L2 can give rise to efficient π-π and H-bonding interactions with dsDNA. Additionally, stacking interactions allowed L2 to stabilize the G-quadruplex structure: using the human telomeric sequence, we observed the preferential induction of tetrameric G-quadruplex forms. Thus, the presence of short ethylene spacers seems to be essential for obtaining a correct match between the binding sites of L2 and the nucleobases on both DNA forms investigated. Furthermore, current modeling methodologies, including docking and MD simulations and free energy calculations, provide structural evidence of an interaction mode for L2 that is different from that of L3; this could explain the unusual stabilizing ability of the ligands (L2>L3>L1) toward G-quadruplex that was observed in this study. 相似文献
47.
Federico Galvanin Massimiliano Barolo Fabrizio Bezzo Sandro Macchietto 《American Institute of Chemical Engineers》2010,56(8):2088-2102
Model‐based experiment design techniques are an effective tool for the rapid development and assessment of dynamic deterministic models, yielding the most informative process data to be used for the estimation of the process model parameters. A particular advantage of the model‐based approach is that it permits the definition of a set of constraints on the experiment design variables and on the predicted responses. However, uncertainty in the model parameters can lead the constrained design procedure to predict experiments that turn out to be, in practice, suboptimal, thus decreasing the effectiveness of the experiment design session. Additionally, in the presence of parametric mismatch, the feasibility constraints may well turn out to be violated when that optimally designed experiment is performed, leading in the best case to less informative data sets or, in the worst case, to an infeasible or unsafe experiment. In this article, a general methodology is proposed to formulate and solve the experiment design problem by explicitly taking into account the presence of parametric uncertainty, so as to ensure both feasibility and optimality of the planned experiment. A prediction of the system responses for the given parameter distribution is used to evaluate and update suitable backoffs from the nominal constraints, which are used in the design session to keep the system within a feasible region with specified probability. This approach is particularly useful when designing optimal experiments starting from limited preliminary knowledge of the parameter set, with great improvement in terms of design efficiency and flexibility of the overall iterative model development scheme. The effectiveness of the proposed methodology is demonstrated and discussed by simulation through two illustrative case studies concerning the parameter identification of physiological models related to diabetes and cancer care. © 2009 American Institute of Chemical Engineers AIChE J, 2010 相似文献
48.
The fundamental dynamic behaviour of a middle-vessel continuous distillation column is studied in this paper. The interaction between the middle vessel (MV) design and control parameters is identified by means of a linear analysis. Transfer functions relating the dynamics of the product composition responses to changes in the disturbance inputs and manipulated inputs are derived. The role of the MV holdup and MV level controller gain in altering the product composition responses is identified. It is shown that the MV level controller gain can significantly affect the control performance when feed flow disturbances must be compensated for. However, it has a much lower impact in the control performance when feed composition disturbances need to be rejected; in this case, exploiting the “buffering” effect of the MV is more important for control. The analysis is carried out in detail for a LV control configuration, and is subsequently extended to an “on-demand” DB configuration. Finally, simple guidelines for the choice of the MV level controller gain and MV holdup are provided. 相似文献
49.
Roberto Chiabrando Enrico Fabrizio Gabriele Garnero 《Renewable & Sustainable Energy Reviews》2009,13(9):2441-2451
The installation and operation of systems that exploit solar energy through photovoltaic conversion, recently promoted in some European countries by new sell-back tariffs, is a relevant transformation of the territory for various reasons (land use, elimination of the existing vegetation, visual impact on the components of the landscape, microclimate change, glare from the reflection of the direct sunlight). The weak energy intensity of the solar source coupled with the low conversion efficiency of the photovoltaic cells, make the physical dimensions of such systems relevant and, with them, also the environmental, territorial and landscape impacts that basically depend on the physical extent of the system. If it is well known that an incentive to the exploitation of renewable sources is one of the features of the policy of land conservation, including the one of the protected areas, at the same time the concerns of local communities and governments about the environmental, territorial and landscape impacts of this technology are increasing rapidly.Given this picture, this work is intended to clarify the territorial impacts of the ground mounted photovoltaic systems. Later, the paper concentrates on a specific impact, which is the assessment of the risk of glare by reflection of direct sunlight from the surfaces of photovoltaic modules. The methodologies that can be used to assess this impact and the outcomes of an evaluation carried out for a 5000 m2 PV system currently designed on a hilly territory in Italy are presented. 相似文献
50.
This paper deals with the performance of a Carbon Nano Tube Field Effect Transistor (CNTFET) in the presence of undeposited CNTs as defects. A simulation-based analysis of delay degradation due to different features (such as chirality and defective CNT distribution) is initially pursued. Two solutions to mitigate the change in delay are proposed; these approaches are based on adjusting the gate width of the CNTFET by lithography (and removing CNTs) as part of the fabrication process. These two methods reduce the average delay and its deviation, respectively. A probabilistic delay analysis is then presented. The performance of the proposed two adjustment methods is evaluated by considering CNT features (such as chirality and defect distribution) deterministically and probabilistically. By deterministic (probabilistic) simulation, the first method reduces on average the delay by 6.968 % (7.811 %) while the deviation is increased (decreased) by 32.444 % (9.788 %). The second method reduces deterministically (probabilistically) on average the deviation by 44.159 % (47.476 %) with 2.166 % (4.409 %) delay reduction. 相似文献