全文获取类型
收费全文 | 1065篇 |
免费 | 64篇 |
国内免费 | 5篇 |
学科分类
工业技术 | 1134篇 |
出版年
2024年 | 3篇 |
2023年 | 23篇 |
2022年 | 105篇 |
2021年 | 97篇 |
2020年 | 52篇 |
2019年 | 45篇 |
2018年 | 39篇 |
2017年 | 43篇 |
2016年 | 54篇 |
2015年 | 45篇 |
2014年 | 59篇 |
2013年 | 88篇 |
2012年 | 67篇 |
2011年 | 88篇 |
2010年 | 48篇 |
2009年 | 55篇 |
2008年 | 50篇 |
2007年 | 36篇 |
2006年 | 27篇 |
2005年 | 30篇 |
2004年 | 15篇 |
2003年 | 19篇 |
2002年 | 7篇 |
2001年 | 4篇 |
2000年 | 7篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1990年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有1134条查询结果,搜索用时 15 毫秒
51.
Marcello BragliaAuthor Vitae Davide CastellanoMarco FrosoliniAuthor Vitae 《Computers in Industry》2014
The present paper provides the schema for an innovative and modular computer-based approach to the planning of activities in large-scale projects. Such projects are characterized by tens of thousands of tasks, which are consequently burdensome and difficult to plan manually. This is true to the point that in many shipyards only a low level of detail is used and poor planning is generally performed. The proposed approach is called computer-aided activity planning (CAAP), and an application in the yachting industry is shown to demonstrate its effectiveness. In particular, the so-called outfitting planning problem is faced. The CAAP system, taking into account the available shipyard resources and the knowledge on the building rules is able to automatically define, sequence, and schedule the activities of the whole outfitting process acting as a “planning configurator”. Moreover, it allows the industry-specific knowledge to be stored, maintained and shared within the (extended) organization. Owing to these “building blocks”, plans can be defined accurately and in a shorter time starting from pre-defined templates, with particular impact on lead times whenever variations to complex projects are needed. Finally, to verify the actual capabilities of the approach, the CAAP was implemented within a prototypical software called NautiCAAP. 相似文献
52.
Giuseppe Espa Danila Filipponi Diego Giuliani Davide Piacentino 《Papers in Regional Science》2014,93(Z1):S113-S135
In this paper, spatial shift‐share decomposition is analysed when applied to Italian data on regional business change at plant level, over the period 2004–2009. A new type of spatial decomposition, which looks more effectively at neighbourhood influence, is introduced here. Notable results emerge from the empirical investigation. First, it can be seen that the spatial level of aggregation greatly affects results. Second, evidence of neighbourhood advantage in the Southern NUTS 3 regions is found, together with opposite results for the Central‐Northern NUTS 3 regions. Finally, evidence of positive industrial mix effects is only found in Central‐Northern Italy. 相似文献
53.
54.
Cristina Cornaro Simona Bartocci Davide Musella Cecilia Strati Alessandro Lanuti Simone Mastroianni Stefano Penna Andrea Guidobaldi Fabrizio Giordano Eleonora Petrolati Thomas M. Brown Andrea Reale Aldo Di Carlo 《Progress in Photovoltaics: Research and Applications》2015,23(2):215-225
New generation photovoltaic (PV) devices such as polymer and dye sensitized solar cells (DSC) have now reached a more mature stage of development, and among their various applications, building integrated PVs seems to have the most promising future, especially for DSC devices. This new generation technology has attracted an increasing interest because of its low cost due to the use of cheap printable materials and simple manufacturing techniques, easy production, and relatively high efficiency. As for the more consolidated PV technologies, DSCs need to be tested in real operating conditions and their performance compared with other PV technologies to put into evidence the real potential. This work presents the results of a 3 months outdoor monitoring activity performed on a DSC mini‐panel made by the Dyepower Consortium, positioned on a south oriented vertical plane together with a double junction amorphous silicon (a‐Si) device and a multi‐crystalline silicon (m‐Si) device at the ESTER station of the University of Rome Tor Vergata. Good performance of the DSC mini‐panel has been observed for this particular configuration, where the DSC energy production compares favorably with that of a‐Si and m‐Si especially at high solar angles of incidence confirming the suitability of this technology for the integration into building facades. This assumption is confirmed by the energy produced per nominal watt‐peak for the duration of the measurement campaign by the DSC that is 12% higher than that by a‐Si and only 3% lower than that by m‐Si for these operating conditions. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
55.
Giuseppe Floresta Chiara Zagni Davide Gentile Vincenzo Patamia Antonio Rescifina 《International journal of molecular sciences》2022,23(6)
The recent covid crisis has provided important lessons for academia and industry regarding digital reorganization. Among the fascinating lessons from these times is the huge potential of data analytics and artificial intelligence. The crisis exponentially accelerated the adoption of analytics and artificial intelligence, and this momentum is predicted to continue into the 2020s and beyond. Drug development is a costly and time-consuming business, and only a minority of approved drugs generate returns exceeding the research and development costs. As a result, there is a huge drive to make drug discovery cheaper and faster. With modern algorithms and hardware, it is not too surprising that the new technologies of artificial intelligence and other computational simulation tools can help drug developers. In only two years of covid research, many novel molecules have been designed/identified using artificial intelligence methods with astonishing results in terms of time and effectiveness. This paper reviews the most significant research on artificial intelligence in de novo drug design for COVID-19 pharmaceutical research. 相似文献
56.
57.
Biagio Barone Luigi Napolitano Marco Abate Luigi Cirillo Pasquale Reccia Francesco Passaro Carmine Turco Simone Morra Francesco Mastrangelo Antonio Scarpato Ugo Amicuzi Vincenzo Morgera Lorenzo Romano Francesco Paolo Calace Savio Domenico Pandolfo Luigi De Luca Achille Aveta Enrico Sicignano Massimiliano Trivellato Gianluca Spena Carlo DAlterio Giovanni Maria Fusco Raffaele Vitale Davide Arcaniolo Felice Crocetto 《International journal of molecular sciences》2022,23(7)
Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Testosterone replacement therapy (TRT) shows several therapeutic effects while maintaining a good safety profile in hypogonadal men. TRT restores normal levels of serum testosterone in men, increasing libido and energy level and producing beneficial effects on bone density, strength and muscle as well as yielding cardioprotective effects. Nevertheless, TRT could be contraindicated in men with untreated prostate cancer, although poor findings are reported in the literature. In addition, different potential side effects, such as polycythemia, cardiac events and obstructive sleep apnea, should be monitored. The aim of our review is to provide an updated background regarding the pros and cons of TRT, evaluating its role and its clinical applicability in different domains. 相似文献
58.
Davide Loizzo Savio Domenico Pandolfo Devin Rogers Clara Cerrato Nicola Antonio di Meo Riccardo Autorino Vincenzo Mirone Matteo Ferro Camillo Porta Alessandro Stella Cinzia Bizzoca Leonardo Vincenti Marco Spilotros Monica Rutigliano Michele Battaglia Pasquale Ditonno Giuseppe Lucarelli 《International journal of molecular sciences》2022,23(7)
Autophagy is a complex process involved in several cell activities, including tissue growth, differentiation, metabolic modulation, and cancer development. In prostate cancer, autophagy has a pivotal role in the regulation of apoptosis and disease progression. Several molecular pathways are involved, including PI3K/AKT/mTOR. However, depending on the cellular context, autophagy may play either a detrimental or a protective role in prostate cancer. For this purpose, current evidence has investigated how autophagy interacts within these complex interactions. In this article, we discuss novel findings about autophagic machinery in order to better understand the therapeutic response and the chemotherapy resistance of prostate cancer. Autophagic-modulation drugs have been employed in clinical trials to regulate autophagy, aiming to improve the response to chemotherapy or to anti-cancer treatments. Furthermore, the genetic signature of autophagy has been found to have a potential means to stratify prostate cancer aggressiveness. Unfortunately, stronger evidence is needed to better understand this field, and the application of these findings in clinical practice still remains poorly feasible. 相似文献
59.
Davide Ciardiello Brigida Anna Maiorano Paola Parente Maria Grazia Rodriquenz Tiziana Pia Latiano Cinzia Chiarazzo Valerio Pazienza Luigi Pio Guerrera Brunella Amoruso Nicola Normanno Giulia Martini Fortunato Ciardiello Erika Martinelli Evaristo Maiello 《International journal of molecular sciences》2022,23(2)
Biliary tract cancers (BTC) represent a heterogeneous and aggressive group of tumors with dismal prognosis. For a long time, BTC has been considered an orphan disease with very limited therapeutic options. In recent years a better understanding of the complex molecular landscape of biology is rapidly changing the therapeutic armamentarium. However, while 40–50% of patients there are molecular drivers susceptible to target therapy, for the remaining population new therapeutic options represent an unsatisfied clinical need. The role of immunotherapy in the continuum of treatment of patients with BTC is still debated. Despite initial signs of antitumor-activity, single-agent immune checkpoint inhibitors (ICIs) demonstrated limited efficacy in an unselected population. Therefore, identifying the best partner to combine ICIs and predictive biomarkers represents a key challenge to optimize the efficacy of immunotherapy. This review provides a critical analysis of completed trials, with an eye on future perspectives and possible biomarkers of response. 相似文献
60.
Stefano Ravaioli Davide Campoccia Werner Ruppitsch Franz Allerberger Alessandro Poggi Emanuele Chisari Lucio Montanaro Carla Renata Arciola 《International journal of molecular sciences》2022,23(3)
108 isolates of Staphylococcus aureus, belonging to six large ribogroups according to the automated Ribo-Printer® system, were studied with two highly used molecular methods for epidemiological studies, namely multi-locus sequence typing (MLST) and spa typing, followed by BURP and eBURST v3 analysis for clustering spa types and sequence (ST) types. The aim was to evaluate whether automated ribotyping could be considered a useful screening tool for identifying S. aureus genetic lineages with respect to spa typing and MLST. Clarifying the relationship of riboprinting with these typing methods and establishing whether ribogroups fit single clonal complexes were two main objectives. Further information on the genetic profile of the isolates was obtained from agr typing and the search for the mecA, tst genes, and the IS256 insertion sequence. Automated ribotyping has been shown to predict spa clonal complexes and MLST clonal complexes. The high cost and lower discriminatory power of automated ribotyping compared to spa and MSLT typing could be an obstacle to fine genotyping analyzes, especially when high discriminatory power is required. On the other hand, numerous advantages such as automation, ease and speed of execution, stability, typeability and reproducibility make ribotyping a reliable method to be juxtaposed to gold standard methods. 相似文献