Research on machine recognition of handprinted characters

Machine recognition of handprinted Chinese characters has recently become very active in Japan. Both from the practical and the academic point of view, very encouraging results are reported. The work is described systematically and analyzed in terms of so-called feature matching, which is likely to be the mainstream of the research and development of machine recognition of handprinted Chinese characters. A database, ETL8 (881 Kanji, 71 hirakana, and 160 variations for each category), is explained, on which many experiments were performed. Recognition rates reported using this database can be compared, and so somewhat qualitative evaluation of these methods is described. Based on the comparative study, the merits and demerits of both feature and structural matching are discussed and some future directions are mentioned.     

Construction of a brain–machine hybrid system to evaluate adaptability of an insect

Insects perform adaptive behavior according to changing environmental conditions using comparatively small brains. Because adaptability is generated through the relationship among brain, body and environment, it is necessary to examine how a brain works under these conditions. In this study, to understand neural processing involved in adaptive behavior, we constructed a brain–machine hybrid system using motor signals related to the steering behavior of the male silkworm moth for controlling a two-wheeled mobile robot. We developed this hybrid system according to the following steps. (1) We selected steering signals corresponding to walking direction that were activated during neck swinging induced by optic flow and pheromone stimuli. (2) To control a robot by neural activity, we implemented a spike-behavior conversion rule such that frequency of the left and right neck motor neurons’ spikes was linearly converted into rotation of the wheels. (3) For electrophysiological multi-unit recordings on a robot, we developed small amplifiers. Using this hybrid system, we could observe the programmed behavioral pattern and orientation toward a pheromone source. Moreover, we compared the orientation behavior of moths and that of the hybrid system at different pheromone stimulus frequencies. From these experiments, we concluded that we could reconstruct silkworm moth behavior on the hybrid system.     

Dynamic alternation of primate response properties during trial-and-error knowledge updating

Humans and animals seek appropriate solutions to novel problems through trial-and-error (TE) actions and observation of their outcomes. Once an individual has obtained the knowledge (rule) to solve a problem, knowledge-based (KB) actions may be applied in a stereotypical manner. Solutions can thus be based on TE or KB actions. To characterize this learning process at the behavioral level, we developed a new cognitive task for a laboratory monkey (Macaca fuscata) to perform. In this task, a search array consisting of six elements of different colors was presented, one of which was the behaviorally relevant target. The target color was changed unpredictably with no instruction or signal, requiring the monkey to use a TE search strategy to find the target color. We found that once the monkey identified the relevant color by chance after a color change, correct performance increased in a step-like manner and at the same time, other response properties (reaction time and color-choice tendency) also changed discontinuously. These step-like alternations in behavioral performance may be attributed to the subject’s switching between TE and KB search strategies in the two phases. The present study has therefore provided behavioral evidence for the timing and manner of switching between search strategies during the process of updating knowledge.     

Studies of the pH of the membrane surface in a laboratory chlor-alkali cell

The pH on the surface of an ion-exchange membrane was measured with a microprobe in a laboratory scale chlor-alkali cell to study the leakage of OH^– through the membrane. The solution pH in the vicinity of the membrane facing the anode was found to be considerably higher than that in the bulk solution because of penetration and leakage of OH^–. The pH varied with the membrane type. This explains why the carboxylate membrane is not protonated and can be used as a separator in chlor-alkali cells.Deceased.     

Effect of heparin on high glucose induced proliferation and expression of matrix metalloproteinases in normal human mesangial cells

Background The pathogenesis of diabetic nephropathy (DN) is a complex pathophysiological process. Its precise mechanism is not fully known. In recent years it has been recognized that synthesis of various extracelluar matrix (ECM) components may increase, and that degradation of ECM may decrease in DN. It was reported heparin could inhibit mesangial cells proliferation in vitro. The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells. Methods The medium contained either low glucose (5 mmol/L) or high glucose (25 mmol/L). The concentrations of heparin in the culture medium were 0, 25, 50, 100, 200 or 400 μg/mL. A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells. Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium. They showed a 1.93 fold expansion after 72 h in high glucose in contrast to a 1.63 fold expansion in low glucose. In the presence of heparin, mesangial cells proliferation was inhibited, which was more obvious at high glucose concentrations than at low glucose concentrations. In high glucose, with heparin concentration of 50, 100, 200 and 400 μg/mL, the mesangial cells showed a 0.61 fold, 0.52 fold, 0.52 fold and 0.41 fold reductions in cell number compared to cells grown without heparin. In low glucose, only concentrations of 200 μg/mL and 400 μg/mL showed reduction in cell number, namely 0.54 fold and 0.45 fold, when compared to cells grown without heparin. In Western blot analysis, MMP₁, MMP₂, MMP₃ and MMP₉ was expressed by mesangial cells expressed in both high and low glucose concentrations, which was more prominent in high glucose medium. Incubation of heparin further increased expression of MMP₁, MMP₂, MMP₃ and MMP₉. Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations. Higher glucose concentrations led to increased MMP expression, which may take part in the regulation of mesangial matrix synthesis and degradation. Addition of heparin resulted in a corresponding increase in MMP expression, most notably at high glucose concentrations, indicating a potentially renoprotective role in DN. Foundation item: Project (30370663) supported by the National Natural Science Foundation of China     

A novel chromatographic separation technique using tertiary pyridine resin for the partitioning of trivalent actinides and lanthanides

A novel chromatographic separation technique using a tertiary pyridine type resin has been applied to the partitioning of the trivalent actinides (An) and lanthanides (Ln) and several successful results have been shown. In an alcoholic hydrochloric acid system, the trivalent An were clearly separated from the Ln, while no such group separation was achieved in an alcoholic nitric acid system. On the other hand, the nitric acid system was more effective for the intragroup (i.e. individual) separation of the trivalent An and the Ln than the hydrochloric acid system. On the basis of these results, a novel concept for the partitioning of the trivalent An and Ln using the present separation technique and its flowchart have been proposed with its advantages and disadvantages.     

Development of specimen and test method for strength analysis of MEMS micromirror

Specimens and fracture test methods for strength analysis of MEMS micromirrors were proposed. Bending and combined loading tests were performed, and torsion strength was estimated from those results. Two-parameter Weibull distribution was used to evaluate the fracture stresses estimated from the FEM model. The resulting scale and shape parameters were 787 MPa and 7.77 for the bending test and 517 MPa and 5.28 for the combined loading test. There was a difference in strength between the results of the bending and combined loading tests. From the load factor analysis, it was found that both geometry and stress distribution have to be considered to estimate the strength of MEMS since flaws are non-uniformly distributed. It was also found that torsional strength can be estimated on the safe side using the results of the combined loading test.     

ISS experiments for the clarification of boiling and two-phase flow in microgravity and for the development of high-performance space cold plates

Inflow boiling, gravity effects on the distribution of both phases are observed in a heated tube and heat transfer coefficients due to two-phase forced convection is deteriorated in microgravity. In narrow channels between heated and unheated plates, the increase in subcooling enlarges a size of flattened bubble and reduces the frequency of detachment under microgravity conditions resulting the emphasis of heat transfer deterioration. To clarify reasons for the unknown behaviors of interfacial distribution and corresponding characteristics in heat transfer not easily be clarified through the experiments on ground, the opportunity on the experiments utilizing long-term microgravity duration realized in ISS is required. The experiments on microgravity boiling and two-phase flow are proposed by the collaboration of researchers in five countries. A common test loop is designed to conduct multiple experiments by the interchangeable structures of test sections; a transparent heated tube for the visualized flow boiling, a stainless tube for the measurement of CHF data, a copper surface for the heat transfer data of nucleate boiling with superimposed liquid flows in a duct, a glass heated plate with multiple array of small temperature sensors and transparent heaters for the clarification of mechanisms in nucleate boiling heat transfer, and one or two models of cold plates for practical applications. A direction of researches in the present discipline is proposed based on the existing experimental results and on the idea developed by the present authors.